Explore top 2026 5 Star Hotels in Tupelo

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Tupelo Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Tupelo to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Tupelo 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Tupelo before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Tupelo hotel reviews by fellow wanderers

La Quinta Inn & Suites by Wyndham Tupelo

La Quinta Inn & Suites by Wyndham Tupelo

4 out of 5
Posted 2 hours ago
Travelocity Verified Review
"We arrived late at night, and our floor smelled of weed. When we arrived at the room, the door was wide open, TV on, beds unmade with trash still in the trash cans. We went back to the front desk and requested a new room. The staff were apologetic and helpful. They quickly issued us a new room, on the same weed smelling floor, but the stay was quiet after that. No complaints, just "smoke free" is only for those who abide by the rules in most hotels. Mistakes happen, but a staff that quickly corrected them was appreciated."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Tupelo
La Quinta Inn & Suites by Wyndham Tupelo

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