Explore top 2026 4 Star Hotels in Colon

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Top Colon 4 Star hotels

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $125 total per night from May 1 to May 2
$125 total
May 1 - May 2
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,001 reviews)
The hotel needs urgently a renovation. The staff is poorly trained

Reviewed on Apr 12, 2026

Opens in a new windowSheraton Grand Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $123 total per night from May 5 to May 6
$123 total
May 5 - May 6
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
7.8/10 Good! (1,015 reviews)
The breakfast menu was fresh, and they had a wide selection of things to choose from, the staff was very friendly and willing to help once you called up on them

Reviewed on Apr 15, 2026

Opens in a new windowHotel El Panama by Faranda Grand, a member of Radisson Individuals
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $100 total per night from Apr 28 to Apr 29
$100 total
Apr 28 - Apr 29
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (853 reviews)
Breakfast was good. Rooms were clean. A bit noisy at night not from the casino but other guests gathering in the hall instead of their room…

Reviewed on Apr 15, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
$95 nightly
The price is $105 total per night from May 12 to May 13
$105 total
May 12 - May 13
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,174 reviews)
Everything was great

Reviewed on Apr 14, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
$101 nightly
The price is $111 total per night from May 9 to May 10
$111 total
May 9 - May 10
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,002 reviews)
Shopped nearby

Reviewed on Apr 13, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $122 total per night from May 10 to May 11
$122 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,161 reviews)
Breakfast was very good

Reviewed on Apr 13, 2026

Opens in a new windowNovotel Panama City
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $177 total per night from Apr 25 to Apr 26
$177 total
Apr 25 - Apr 26
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,014 reviews)
Guess did not like the fact that there was absolutely nothing in room fridge not even as simple as bottle water

Reviewed on Apr 15, 2026

Opens in a new windowMarriott Panama Hotel
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $226 total per night from May 1 to May 2
$226 total
May 1 - May 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (701 reviews)
Staff excellent and very helpful

Reviewed on Apr 13, 2026

Opens in a new windowAmerican Trade Hotel
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $144 total per night from May 1 to May 2
$144 total
May 1 - May 2
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.6/10 Excellent! (1,639 reviews)
Yes the casino was lively and no it wasn't run down.

Reviewed on Apr 13, 2026

Opens in a new windowDecapolis Hotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (590 reviews)
Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here

Reviewed on Mar 26, 2026

Opens in a new windowStudio Coliving
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4 Star Hotels Colon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Colon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Colon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Colon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Colon hotel reviews by fellow wanderers