Explore top 2025 4 Star Hotels in Colon

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Top Colon 4 Star hotels

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $132 total per night from Dec 16 to Dec 17
$132 total
Dec 16 - Dec 17
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,224 reviews)
The room was fantastic i really loved it thank you

Reviewed on Nov 24, 2025

Opens in a new windowMegapolis Hotel Panamá
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $168 total per night from Nov 30 to Dec 1
$168 total
Nov 30 - Dec 1
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,023 reviews)
Room price is reasonable, location is good!

Reviewed on Nov 24, 2025

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $156 total per night from Dec 7 to Dec 8
$156 total
Dec 7 - Dec 8
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,013 reviews)
short stay left a 5 am

Reviewed on Nov 27, 2025

Opens in a new windowMarriott Panama Hotel
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Dec 9 to Dec 10
$99 total
Dec 9 - Dec 10
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9/10 Wonderful! (1,016 reviews)
Very clean everyone was very helpful. There was a smile on all employees face at all time overall five star. I work for the Ritz-Carlton Grand cayman for over 12 years , the cleanliness was very impressive

Reviewed on Nov 25, 2025

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
Fully refundableReserve now, pay when you stay
$44 nightly
The price is $49 total per night from Nov 30 to Dec 1
$49 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (567 reviews)
Only had one towel for my entire stay, remote was not working, pool furniture were all broken

Reviewed on Nov 21, 2025

Opens in a new windowStudio Coliving
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $84 total per night from Nov 30 to Dec 1
$84 total
Nov 30 - Dec 1
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,410 reviews)
Clean room, staff was friendly and helpful. Easy access to shopping and restaurants. There was limited choice for hot breakfast, which was disappointing. But the pool area was great!

Reviewed on Nov 25, 2025

Opens in a new windowDecapolis Hotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $108 total per night from Nov 30 to Dec 1
$108 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.4/10 Exceptional! (1,099 reviews)
Breakfast was good.

Reviewed on Nov 26, 2025

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $289 total per night from Dec 4 to Dec 5
$289 total
Dec 4 - Dec 5
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (594 reviews)
We had a great two-night stay in this central historic district hotel. We had a large comfortable bed, nice view & light, and great service.

Reviewed on Nov 25, 2025

Opens in a new windowAmerican Trade Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $140 total per night from Dec 5 to Dec 6
$140 total
Dec 5 - Dec 6
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.4/10 Very Good! (980 reviews)
Excelente atención y servicio La cuna de bebé era de material como fierro, insegura para bebés que ya se paran un poco El área de juegos de niños siempre mojada y no tenía protección solar podría adecuarse mejor

Reviewed on Nov 1, 2025

Opens in a new windowSheraton Grand Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Dec 11 to Dec 12
$99 total
Dec 11 - Dec 12
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (597 reviews)
Great!

Reviewed on Nov 24, 2025

Opens in a new windowWaymore Hotel Spa & Casino
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4 Star Hotels Colon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Colon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Colon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Colon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Colon hotel reviews by fellow wanderers