Explore top 2026 4 Star Hotels in Colon

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Top Colon 4 Star hotels

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $232 total per night from Mar 4 to Mar 5
$232 total
Mar 4 - Mar 5
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,437 reviews)
No complaints excellent

Reviewed on Feb 26, 2026

Opens in a new windowMegapolis Hotel Panamá
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $183 total per night from Mar 22 to Mar 23
$183 total
Mar 22 - Mar 23
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,000 reviews)
very friendly staff, amicable, attentive...I love it

Reviewed on Feb 25, 2026

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $167 total per night from Mar 7 to Mar 8
$167 total
Mar 7 - Mar 8
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,003 reviews)
Very great

Reviewed on Feb 26, 2026

Opens in a new windowMarriott Panama Hotel
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $122 total per night from Mar 1 to Mar 2
$122 total
Mar 1 - Mar 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,114 reviews)
Room and food was on point. Great service all around. Pricing is great

Reviewed on Feb 27, 2026

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowStudio Coliving
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Mar 1 to Mar 2
$153 total
Mar 1 - Mar 2
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.6/10 Excellent! (1,579 reviews)
STAFF WAS COURTEOUS

Reviewed on Feb 26, 2026

Opens in a new windowDecapolis Hotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Mar 16 to Mar 17
$121 total
Mar 16 - Mar 17
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,145 reviews)
I had a good stay. Two things though..... 1 >the receptionist should've informed me that i needed to use the room key to activate the elevator and the current to the room! 2 > i reached for breakfast at 630 both days of my stay and the 1st day the sausages were cold and the second day the wings were ...

Reviewed on Feb 27, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$227 nightly
The price is $252 total per night from Mar 8 to Mar 9
$252 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (664 reviews)
Everything was fantastic service and hotel

Reviewed on Feb 26, 2026

Opens in a new windowAmerican Trade Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Mar 8 to Mar 9
$148 total
Mar 8 - Mar 9
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,002 reviews)
Nice staff and everything was great.

Reviewed on Feb 27, 2026

Opens in a new windowSheraton Grand Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $116 total per night from Mar 9 to Mar 10
$116 total
Mar 9 - Mar 10
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
9/10 Wonderful! (740 reviews)
The cleanliness of the room really stood out and they even had staff cleaning the rooms daily. Really enjoyed my stay there and would definitely go again whenever I’m in Panama.

Reviewed on Feb 27, 2026

Opens in a new windowWaymore Hotel Spa & Casino
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4 Star Hotels Colon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Colon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Colon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Colon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Colon hotel reviews by fellow wanderers