Explore top 2026 4 Star Hotels in Colon

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Top Colon 4 Star hotels

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,367 reviews)
The vibes and the view

Reviewed on Jan 11, 2026

Opens in a new windowMegapolis Hotel Panamá
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Jan 31 to Feb 1
$135 total
Jan 31 - Feb 1
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,021 reviews)
Going location, great city views

Reviewed on Jan 4, 2026

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $177 total per night from Jan 31 to Feb 1
$177 total
Jan 31 - Feb 1
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,009 reviews)
Staff is the best ,roof top pool the view so much to mention plus the location is prime to everything to make your stay comfortable.. i visit here at least 7 to 9 times per year ..

Reviewed on Jan 11, 2026

Opens in a new windowMarriott Panama Hotel
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Feb 1 to Feb 2
$121 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9/10 Wonderful! (1,063 reviews)
The breakfast was fresh, everything very clean and the service very professional

Reviewed on Jan 6, 2026

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (586 reviews)
Staff very helpful

Reviewed on Dec 11, 2025

Opens in a new windowStudio Coliving
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $126 total per night from Jan 28 to Jan 29
$126 total
Jan 28 - Jan 29
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,492 reviews)
Good

Reviewed on Jan 8, 2026

Opens in a new windowDecapolis Hotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $122 total per night from Jan 26 to Jan 27
$122 total
Jan 26 - Jan 27
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.4/10 Exceptional! (1,141 reviews)
All good

Reviewed on Jan 10, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $280 total per night from Feb 10 to Feb 11
$280 total
Feb 10 - Feb 11
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (629 reviews)
Nice views from balcony

Reviewed on Jan 8, 2026

Opens in a new windowAmerican Trade Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Feb 13 to Feb 14
$148 total
Feb 13 - Feb 14
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.4/10 Very Good! (1,014 reviews)
Great staff in the location very helpful

Reviewed on Jan 12, 2026

Opens in a new windowSheraton Grand Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Jan 14 to Jan 15
$109 total
Jan 14 - Jan 15
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (650 reviews)
Was a very nice hotel close to the metro line. Lots of great restaurants around the area. The pool was closed for Reno’s but they gave us another hotel pool option close by. The rooms very nice and large.

Reviewed on Jan 8, 2026

Opens in a new windowWaymore Hotel Spa & Casino
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4 Star Hotels Colon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Colon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Colon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Colon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Colon hotel reviews by fellow wanderers