Explore top 2025 4 Star Hotels in Colon

Name: Marriott Panama Hotel
Price range: $148 total
Rating: 9

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Colon 4 Star hotels

Sheraton Grand Panama

Via Israel And 77th Street, Panama City, Panama

$134 nightly

$148 total

Nov 1 - Nov 2

Total with taxes and fees

A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...

8.4/10 Very Good! (964 reviews)

"Centrally located and friendly staff"

Reviewed on Oct 10, 2025

Waymore Hotel Spa & Casino

Calle Augusto Samuel Boyd y Calle Eusebi, Panama City

Fully refundableReserve now, pay when you stay

$88 nightly

$97 total

Nov 1 - Nov 2

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...

9/10 Wonderful! (528 reviews)

"I love this hotel, the breakfast is great, the hotel room spacious and clean. Having a Casino and night club right in your hotel is s super plus. The staff is very friendly snd helpful. The maid service is excellent and the room service team is always on point."

Reviewed on Oct 7, 2025

Megapolis Hotel Panamá

Avenida Balboa, Panama City

Fully refundableReserve now, pay when you stay

$110 nightly

$120 total

Nov 4 - Nov 5

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,122 reviews)

"Great stay"

Reviewed on Oct 13, 2025

Studio Coliving

Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama

Fully refundableReserve now, pay when you stay

$44 nightly

$49 total

Oct 15 - Oct 16

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

7.8/10 Good! (522 reviews)

"El lugar es buen lugar para hospedarse. Quiero ser muy claro con esto. No es un hotel lujoso no es súper bonito. Es un hotel práctico. Tiene muchas cosas para una buena estadía.Muchas cosas del hotel ya están viejas pero funcionales. Me gustó en cuanto calidad precio lo vale. La ubicación y muchas ..."

Reviewed on Oct 14, 2025

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Via Espana 111, Panama City, Panama

Fully refundableReserve now, pay when you stay

$97 nightly

$107 total

Nov 5 - Nov 6

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...

7.6/10 Good! (1,004 reviews)

"Nice"

Reviewed on Oct 4, 2025

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

$96 nightly

$106 total

Nov 7 - Nov 8

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...

9/10 Wonderful! (1,017 reviews)

"Room was always well attended to staff was very friendly and kind breakfast was gd 💕"

Reviewed on Oct 10, 2025

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Paitilla, Panama City, Panama

$133 nightly

$146 total

Oct 31 - Nov 1

Total with taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...

8.8/10 Excellent! (1,006 reviews)

"Room was great. Breakfast was excellent"

Reviewed on Oct 10, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica

Via Israel y Calle 71, San Francisco, Panama City, Panama

This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

9.4/10 Exceptional! (1,066 reviews)

"Room was clean. They dont give you wash clothes for the shower so you have to use a large hand towel to bathe with. However hotel is very clean and anemities are nice. This was my second time here it is very close to good shopping and staff are friendly."

Reviewed on Oct 9, 2025

Get rates

Decapolis Hotel Panama City

Avenida Balboa Con Multicentro, Panama City, Panama

$84 nightly

$92 total

Oct 26 - Oct 27

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.4/10 Very Good! (1,349 reviews)

"Nice rooms and views"

Reviewed on Oct 1, 2025

Marriott Panama Hotel

Roosevelt Ave., Allbrook Mall, Panama City, Panama

Fully refundableReserve now, pay when you stay

$134 nightly

$148 total

Nov 7 - Nov 8

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...

9/10 Wonderful! (1,001 reviews)

"Helpfull staff"

Reviewed on Oct 3, 2025

Don't see what you're looking for?

See all available properties in Colon

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Colon

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Colon 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Colon will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Colon, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.