
$306 Cheap American Airlines flights from St. Louis to Santo Domingo (STL to SDQ)
Find The Best Day To Fly from St. Louis to Santo Domingo
Amazing American Airlines STL to SDQ Flight Deals
The cheapest flights to Las Americas Intl. found within the past 7 days were $525 round trip and $306 one way. Prices and availability subject to change. Additional terms may apply.
SDQ From STL Economy Coach Packages on Similar Airlines



Frequently asked questions
Discover our best American Airlines flight from St. Louis STL to Santo Domingo SDQ
To find the best deals on flights to St. Louis from Santo Domingo with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from St. Louis STL to Santo Domingo SDQ with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $525 to $598, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from St. Louis STL to Santo Domingo SDQ
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from St. Louis to Santo Domingo costs from $306. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Santo Domingo SDQ from St. Louis STL with American Airlines
To find a cheap American Airlines flight from St. Louis STL to Santo Domingo SDQ, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from St. Louis STL to Santo Domingo SDQ
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as September, or if you book a flight with a stopover.
Find nonstop flights from St. Louis STL to Santo Domingo SDQ with American Airlines
If you’re keen to be on Santo Domingo soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from St. Louis STL to Santo Domingo SDQ
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Santo Domingo SDQ from St. Louis STL with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Travelers ❤️ these 🏨 after their flight to Santo Domingo

Reviewed on May 7, 2025

Reviewed on May 4, 2025

Reviewed on May 10, 2025
Popular American Airlines Flight Routes from STL
Top Flights for American Airlines originating from STL
Domestic
- New York to Santo Domingo (JFK - SDQ)
- New York to Orlando (LGA - MCO)
- New York to Montego Bay (JFK - MBJ)
- Los Angeles to Tokyo (LAX - HND)
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- New York to Santiago (JFK - STI)
- San Juan to Orlando (SJU - MCO)
- Atlanta to Las Vegas (ATL - LAS)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Chicago to Las Vegas (ORD - LAS)
International
- Los Angeles to San Salvador (LAX - SAL)
- New York to Santo Domingo (JFK - SDQ)
- Los Angeles to Honolulu (LAX - HNL)
- New York to Montego Bay (JFK - MBJ)
- San Juan to Orlando (SJU - MCO)
- New York to London (JFK - LHR)
- New York to Santo Domingo (JFK - SDQ)
- Philadelphia to Orlando (PHL - MCO)
- Los Angeles to Tokyo (LAX - HND)
- Atlanta to Las Vegas (ATL - LAS)