Cheap Flights to Seneca from $45

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

How Much Does it Cost To Fly To Seneca?

The cheapest prices found with in the last 7 days for return flights were $89 and $45 for one-way flights to Seneca for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel DatesFlights From*
DCAGreerAugust 21 to August 24$163
ORDGreerAugust 23 to August 26$195
LGAGreerAugust 11 to August 13$201
LGAGreerAugust 11 to August 13$201
IAHGreerAugust 19 to August 23$202
EWRGreerJuly 29 to August 6$207
DALGreerAugust 7 to August 15$217
BOSGreerJune 30 to July 9$262
PHLGreerAugust 21 to August 25$276
FCOGreerJune 25 to June 29$933
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
ORDGreerJune 21 to June 28$239
DCAGreerJune 21 to July 8$241
LGAGreerJune 21 to June 30$262
LGAGreerJune 21 to June 30$262
EWRGreerJune 20 to June 22$312
DALGreerJune 21 to July 1$446
BOSGreerJune 21 to June 30$506
PHLGreerJune 21 to June 22$509
IAHGreerJune 21 to July 2$559
FCOGreerJune 22 to June 30$993
*Prices include taxes and fees

Seneca Flight Information

Traveling to
Seneca
Lowest Price
$89
Number of Airlines Serving
Airlines Serving
Breeze Airways
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Seneca Accommodation Deals

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd, Seneca, SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (683 reviews)
"Clean and comfortable. Good location. Close to Clemson University"

Reviewed on May 9, 2025

Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (590 reviews)
Lb
"Room was very clean. Easy to get to room. They pickup the trash and gave us clean linens while we were gone didnt notice they were there. The only thing that was disapointing was the pool was closed"

Reviewed on May 27, 2025

Best Western Seneca-Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (596 reviews)
"Property was very clean that was comfy great for the money"

Reviewed on Jun 8, 2025

Quality Inn Seneca Clemson Area US-123
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Seneca

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (596 reviews)
"Property was very clean that was comfy great for the money"

Reviewed on Jun 8, 2025

Quality Inn Seneca Clemson Area US-123
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Seneca

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Seneca
Stay at this cabin in Seneca. Enjoy free WiFi, a fitness center, and a garden. Popular attractions Lake Keowee and South Cove Park are located nearby.
9/10 Wonderful! (69 reviews)
2025 graduation
"Very peaceful, clean and relaxing. Will definitely go back."

Reviewed on May 26, 2025

Fall fun at the cabin! Convenient to Lake Keowee and Clemson
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (590 reviews)
Lb
"Room was very clean. Easy to get to room. They pickup the trash and gave us clean linens while we were gone didnt notice they were there. The only thing that was disapointing was the pool was closed"

Reviewed on May 27, 2025

Best Western Seneca-Clemson
 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks
Great for families

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Seneca
Book a stay at this beach vacation home in Seneca. Enjoy free WiFi, a beach locale, and a garden. Popular attractions Friendship Recreaction Area and Cross Creek ...
10/10 Exceptional! (189 reviews)

Families like: Pool, kitchen, playground, game room

Lovely Hideaway
"We stayed 4 nights and thoroughly enjoyed the quiet location and the private lake dock. The concrete path to the dock was especially nice and our 2 pups had more fun than we did in the lake. Definitely recommended."

Reviewed on May 23, 2025

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks
Save an average of 15% on thousands of hotels when you're signed in
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (596 reviews)
"Property was very clean that was comfy great for the money"

Reviewed on Jun 8, 2025

Quality Inn Seneca Clemson Area US-123
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Seneca Flight and Hotel Packages

Seneca flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Fairway Forest
Foxhunt at Sapphire Valley
Whole Hearts Bed and Breakfast
Don't see what you're looking for?
See all available trips from Boston to Seneca
View all trips

Need a Car For After Your Flight?

Lowest prices found within the past 10 hours. Prices and availability subject to change. Additional terms may apply.

Plane Tickets To Seneca

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Seneca. Browse through our inventory to explore a wide range of cheap flights to Seneca to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Seneca as you anxiously await to exit the plane and explore what Seneca has to offer. Considering all the amazing local food and culture in Seneca, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Seneca to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Seneca without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Seneca with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Seneca today!

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.