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21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near St. Louis Union Station

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Exterior
Billiards
Indoor pool
Bar (on property)
Interior

Popular amenities

  • Bar

Explore the area

Map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • City Museum
    ‪6 min walk‬
  • Busch Stadium
    ‪14 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

Loft, 2 Queen Beds

  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | 1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.4 out of 10
Exceptional
(64 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Double Room, 2 Queen Beds

8.4 out of 10
Very good
(18 reviews)
  • 369 sq ft
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Room, 1 King Bed, Corner | 1 bedroom, in-room safe, desk, laptop workspace

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(23 reviews)
  • 326 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.0 out of 10
Wonderful
(17 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

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Exterior

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About the neighborhood

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find City Museum and Enterprise Center. Also, St. Louis Union Station is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • Busch Stadium - 14 min walk - 0.8 miles
  • Gateway Arch - 2 min drive - 1.1 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Grand Hall Lounge Union Station - ‬11 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Peabody Lounge - ‬6 min walk
  • ‪Medina Mediterranean Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Languages

English

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Lobby

Hyatt Regency St. Louis at The Arch

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Aug 22 - Aug 23
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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a smoke detector and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

How close is 21C Museum Hotel St Louis to the airport?

21C Museum Hotel St Louis is 18.4 mi (26-min drive) away from the St. Louis Lambert Intl. Airport (STL) airport, the closest popular airport to the property.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Jul 23, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Jul 28, 2025 start from $160.65, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21C Museum Hotel St Louis have an airport shuttle?

Airport shuttle services are not available at 21C Museum Hotel St Louis .

Does 21C Museum Hotel St Louis offer free breakfast?

Free breakfast isn’t provided at 21C Museum Hotel St Louis , but cooked-to-order breakfast is offered for a fee of between USD 10 and 25 per person. It's available every day from 6:30 AM to 1:00 PM.

Is there a casino at 21C Museum Hotel St Louis ?

No, there is no casino at this hotel, but Horseshoe St. Louis Casino (3-min drive) and Casino Queen (4-min drive) are nearby.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM.

Is there free parking at 21C Museum Hotel St Louis ?

Free parking is not available at this hotel. Valet parking is available for USD 50 per day.

Does 21C Museum Hotel St Louis have a pool?

21C Museum Hotel St Louis features an indoor pool.

Does 21C Museum Hotel St Louis have a restaurant?

Yes, there is a restaurant on site.

Does 21C Museum Hotel St Louis have a spa?

This hotel doesn't have a spa, but it does offer massages.

How close is 21C Museum Hotel St Louis to downtown St. Louis?

21C Museum Hotel St Louis is 0.4 mi away from St. Louis.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 917 out of 1266 reviews
Rating 8 - Good. 189 out of 1266 reviews
Rating 6 - Okay. 72 out of 1266 reviews
Rating 4 - Poor. 38 out of 1266 reviews
Rating 2 - Terrible. 50 out of 1266 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Nathanial

Stayed 2 nights in May 2025

10/10 Excellent

Jennifer

Traveled with group, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I always love staying at this hotel! The decor is beautiful and the drinks and food are top notch!
Stayed 1 night in Apr 2025

6/10 Okay

Sandra

Stayed 4 nights in Apr 2025

8/10 Good

Katherine L

Traveled with family
Liked: Cleanliness, room comfort
Disliked: Property conditions & facilities

Beautiful hotel, disappointing service

I wish I had nothing but glowing things to say, but I’m so disappointed about something that happened during our stay. We arrived fairly late in the day and all I wanted was to shower. The shower in our room was broken (the pull to transfer water from the tub to shower was missing). We called the front desk and requested it be fixed or we be moved. We were told they would send engineering. 30 minutes later I called back to ask for an ETA. I was told they’d send them right up. Another 30 minutes later we called to say don’t bother as it was then after 10pm and my son needed to go to sleep. I then did my best to bathe, but it was rather uncomfortable (actually painful at times) trying to crouch under the tub faucet to get clean. It did not feel like the front desk took our request seriously at all. I felt, in fact, quite dismissed when a shower seems not too much to ask at any hotel, let alone one like 21C. I will not be returning to this or any other 21C hotel.
Stayed 2 nights in Apr 2025

10/10 Excellent

KARI

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Apr 2025

10/10 Excellent

Anthony

Traveled with group, Business traveler, Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Apr 2025

10/10 Excellent

John

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfection!
Stayed 2 nights in Apr 2025

10/10 Excellent

Roberta

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Apr 2025

10/10 Excellent

Kaley

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Apr 2025

6/10 Okay

Michael

Stayed 3 nights in Apr 2025

10/10 Excellent

stacey

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Highly recommend! Loved the art museum inside the hotel and the cotton candy that came with the dinner bill! Coffee shop was also fabulous. Comfy beds and the shuffle board was a hit.
Stayed 1 night in Apr 2025

10/10 Excellent

Claudia

Liked: Cleanliness, staff & service, property conditions & facilities
Great hotel
Stayed 4 nights in Apr 2025

2/10 Terrible

Aaron

Traveled with group, Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Disliked: Staff & service
Check-in wasn’t good. Gave away one of our rooms and were told that the room was supposed to have a sofa sleeper and didn’t. Had to pay for another room because of this for four nights.
Stayed 4 nights in Apr 2025

6/10 Okay

Dena

Stayed 3 nights in Apr 2025

10/10 Excellent

Paula

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Apr 2025

10/10 Excellent

Kathy

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Apr 2025

10/10 Excellent

James Bryce

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Apr 2025

10/10 Excellent

Mariah

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

10/10 Excellent

Stephanie

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Wonderful Hotel

We loved all of the staff. Restaurants and bar were superb. Great to walk through their art museum. Excellent location in walking distance of Stifel and Enterprise Center. Hope to visit again soon!
Stayed 4 nights in Apr 2025

10/10 Excellent

Payton

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff were amazing. Highly recommend this hotel. This is the best hotel I’ve ever stayed at.
Stayed 1 night in Apr 2025

10/10 Excellent

David Michael

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Great property
Stayed 4 nights in Apr 2025

8/10 Good

David, Rockville

Liked: Cleanliness, staff & service
Stayed 3 nights in Apr 2025

10/10 Excellent

Kimberly, SPRINGFIELD

Traveled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was gorgeous. Staff was nice. Also stopped in at the museam and ate at the cafe. Was a great getaway while in town for a concert
Stayed 1 night in Apr 2025

10/10 Excellent

Daniel C

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Art museum is on several floors, and is free. Within walking distance of the Arch, downtown museums, sports facilities and Union Station.
Stayed 3 nights in Apr 2025

6/10 Okay

Brian

Traveled with group
Disliked: Cleanliness
Okay
Stayed 1 night in Apr 2025