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21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near St. Louis Union Station

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Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Massages
Bar (on property)
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(89 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(29 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find St. Louis Union Station and City Museum. Also, Enterprise Center is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector, and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

How close is 21C Museum Hotel St Louis to the airport?

21C Museum Hotel St Louis is 18.4 mi (24-min drive) away from the St. Louis Lambert Intl. Airport (STL) airport, the closest popular airport to the property.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Mar 12, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Apr 5, 2026 start from $153, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21C Museum Hotel St Louis have an airport shuttle?

Airport shuttle services are not available at 21C Museum Hotel St Louis .

Does 21C Museum Hotel St Louis offer free breakfast?

Free breakfast isn’t provided at 21C Museum Hotel St Louis , but cooked-to-order breakfast is offered for a fee of between USD 10 and 25 per person. It's available every day from 6:30 AM to 1:00 PM.

Is there a casino at 21C Museum Hotel St Louis ?

No, there is no casino at this hotel, but Horseshoe St. Louis Casino (3-min drive) and Casino Queen (5-min drive) are nearby.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM.

Is there free parking at 21C Museum Hotel St Louis ?

Free parking is not available at this hotel. Valet parking is available for USD 50 per day.

Does 21C Museum Hotel St Louis have a pool?

21C Museum Hotel St Louis features an indoor pool.

Does 21C Museum Hotel St Louis have a restaurant?

Yes, there is a restaurant on site.

Does 21C Museum Hotel St Louis have a spa?

This hotel doesn't have a spa, but it does offer massages.

How close is 21C Museum Hotel St Louis to downtown St. Louis?

21C Museum Hotel St Louis is 0.4 mi away from St. Louis.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1174 out of 1648 reviews
Rating 8 - Good. 252 out of 1648 reviews
Rating 6 - Okay. 114 out of 1648 reviews
Rating 4 - Poor. 49 out of 1648 reviews
Rating 2 - Terrible. 59 out of 1648 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

Reviews

10/10 Excellent

Austin

Stayed 4 nights in Feb 2026

4/10 Poor

Katherine

Liked: Amenities
Greeted with an ask for a cc. Told this $230 room hotel that it was my sisters bday and asked if anything could be done. I was told no. It’s not hard to make someone’s day. Esp in the hospitality industry. Not asking for freebies, just asking for a simple gesture to make someone’s stay unforgettable for their birthday. Super disappointed.
Stayed 1 night in Jan 2026

10/10 Excellent

Kevin, Leawood

Traveled with partner, Traveled with pets
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
If you have ever wanted to step inside a Wes Anderson film—complete with the perfect symmetry, whimsical color palettes, and that distinct feeling of curated reality—the 21c Museum Hotel in St. Louis is it. The rooms are the true showstopper. Opening the door felt less like entering a hotel room and more like being transported to a high-end, 1960s Mad Men-inspired apartment. The attention to detail is staggering. The aesthetic is a masterclass in mid-century modern design, featuring rich wood paneling, deep jewel tones, and opulent finishings that scream Don Draper excellence. The furniture feels substantial and curated, not mass-produced, with tactile fabrics and silhouettes that anchor the space in that golden era of design. And then, there is the bathroom. I can say, without hyperbole, that this is the best bathroom of any hotel we’ve ever stayed at. It is an absolute sanctuary. The design continues that opulent, retro-modern theme with stunning tiling and heavy, brushed brass fixtures that feel incredible to use. It’s spacious and bright, featuring a vanity area that actually allows you to spread out. The shower pressure was perfect, and the high-end amenities (Malin+Goetz) were the cherry on top. It’s the kind of bathroom that makes you want to renovate your own home the second you leave. The 21c St. Louis manages to thread the needle between a serious art gallery and a cozy, nostalgic retreat.
Stayed 1 night in Nov 2025

10/10 Excellent

Ashton

Traveled with group, Business traveler, Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The hotel is beautiful! It was a great pick for so much to do on the property. From the pool area with hot tub and saunas . To the art gallery, and the stubbing bar! Grab some fantastic cocktails! Ask for Sunday, she was wonderful bartending! Perfect stay.
Stayed 2 nights in Nov 2025

10/10 Excellent

Mark

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We stay every year for Dirt in December at the Dome. And we enjoy are stay every year.
Stayed 3 nights in Dec 2025

8/10 Good

Sarah, Oakland

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Nov 2025

8/10 Good

Patricia

Traveled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
No parking available other than $50 valet with tip expected every time you get your car. Price is for 24 hours only. Hotel room and staff are excellent. Pricey. For the price, breakfast should be included. A small coffee shop and bar are located near the lobby. Again, pricey.
Stayed 1 night in Dec 2025

10/10 Excellent

christopher

Stayed 1 night in Nov 2025

10/10 Excellent

Rufus

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Dec 2025

6/10 Okay

David

The Ac/heat in room 508 was very difficult to control, it would pump a ton of heat and then a ton of cold,
Stayed 1 night in Dec 2025

8/10 Good

Tara

Traveled with group
Liked: Cleanliness, amenities, property conditions & facilities
The rooms were well curated, super crisp and really nicely designed.
Stayed 1 night in Dec 2025

4/10 Poor

Christopher

Disliked: Cleanliness
Room was very dirty, glass top table where coffee maker was covered in an unknown dried liquid, floors were very dirty, found used silverware next to the nightstand on the floor. There was something splattered and dried on the wall, coffee cups had a white film in bottom of glasses that looked like milk. This is my third time staying at 21C and definitely my last.
Stayed 3 nights in Dec 2025

10/10 Excellent

Cory

Liked: Cleanliness, amenities, property conditions & facilities
Very clean nice place. Staff was very nice and helpful
Stayed 2 nights in Dec 2025

10/10 Excellent

Barbara

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The room was spotless and the details were beautiful. The hotel was a really fun experience!
Stayed 1 night in Oct 2025

10/10 Excellent

London

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Room was perfect and parking was a breeze. We really enjoyed the art was wonderful.
Stayed 1 night in Nov 2025

8/10 Good

Sandra

Traveled with pets
Liked: Cleanliness, amenities, property conditions & facilities
This hotel is incredible. So beautiful with all the amenities. Good price for the night through Expedia as well. I do have to say, the front desk was very young and without knowledge of if dogs were allowed in the bar (they are), what time the pool opens (ChatGPT says 5 AM but it's actually 6 am), and generally we're not excited to help guests. Other than that, I would stay here again for sure!
Stayed 1 night in Dec 2025

8/10 Good

Darnell

Stayed 2 nights in Nov 2025

8/10 Good

James

Room layout and as good but the bathroom needed a strong turnout from bad caulk seals to discolored shower wall tiles
Stayed 2 nights in Oct 2025

10/10 Excellent

Jenifer

Liked: Cleanliness, amenities, property conditions & facilities
Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area.
Stayed 1 night in Nov 2025

10/10 Excellent

Frank

Liked: Cleanliness, amenities, property conditions & facilities
Awesome hotel. One of the best I've stayed in. However, they need a good chef in both the bar/restaurant and the cafe. Other than the food, it was great.
Stayed 3 nights in Nov 2025

10/10 Excellent

Laura

Liked: Cleanliness, staff & service, amenities
Clean room. Yummy dinner. Beautiful artwork.
Stayed 1 night in Nov 2025

10/10 Excellent

Cullin

Stayed 1 night in Nov 2025

4/10 Poor

Jonathan

Stayed 1 night in Nov 2025

8/10 Good

Evan

Liked: Cleanliness, staff & service, amenities
Love this hotel and have stayed many times. Original room was not suitable (no iron or coffee machine, which are standard), but front desk quickly gave another room.
Stayed 1 night in Nov 2025

10/10 Excellent

Mark

Traveled with family
Liked: Cleanliness, staff & service, amenities
This place is awesome, it's a destination in itself.
Stayed 1 night in Nov 2025