Explore 57 Luxury Hotels in Central Missouri

Name: Ramada by Wyndham Columbia
Price range: $67 total
Rating: 7.4

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Best Luxury Hotels in Central Missouri

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

103 E 4th St Sedalia MO

Fully refundable

$105 nightly

$120 total

Feb 26 - Feb 27

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...

9.2/10 Wonderful! (587 reviews)

Everything was amazing.

Reviewed on Jan 25, 2026

Camden on the Lake Resort & Spa

2359 Bittersweet Road Lake Ozark MO

$137 nightly

$146 total

Jan 29 - Jan 30

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas and free ...

9/10 Wonderful! (1,001 reviews)

Clean and great staff.

Reviewed on Jan 16, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

Fully refundable

$149 nightly

$169 total

Feb 1 - Feb 2

Total with taxes and fees

A nightclub, 3 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...

8.8/10 Excellent! (1,003 reviews)

Loved the room. Easily went to dinner at Addison’s around the corner and breakfast was great at Glenn’s cafe.

Reviewed on Jan 26, 2026

Best Western Plus Columbia Inn

2904 Clark Lane Columbia MO

Fully refundableReserve now, pay when you stay

$70 nightly

$79 total

Jan 31 - Feb 1

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...

8.8/10 Excellent! (1,226 reviews)

Comfortable, spacious room. Kids bummed, we came for pool to play and it was super cold, couldn’t even get in. Breakfast had good choices. Front desk staff were friendly. Fitness center had machines and free weights.

Reviewed on Jan 21, 2026

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

Fully refundableReserve now, pay when you stay

$59 nightly

$67 total

Feb 2 - Feb 3

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

7.4/10 Good! (1,000 reviews)

The front desk are awesome people

Reviewed on Jan 12, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

$93 nightly

$102 total

Feb 5 - Feb 6

Total with taxes and fees

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...

7.4/10 Good! (1,102 reviews)

very nice

Reviewed on Jan 20, 2026

Laci's Country Inn

410 N Vaughn St Knob Noster MO

$61 nightly

$67 total

Jan 28 - Jan 29

Total with taxes and fees

Free WiFi in public areas is available at this motel. Take advantage of the free self parking.

6.8/10 (162 reviews)

Room was super clean, spacious, and comfy bed. Great staff, fast wifi. Restaurant across the street. Great stay

Reviewed on Jan 7, 2026

Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln Columbia MO

Fully refundableReserve now, pay when you stay

$53 nightly

$60 total

Feb 2 - Feb 3

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.4/10 (1,002 reviews)

Its what you expect in a motel, clean, ample parking, the heat worked fine, clean room, and no offensive orders. All and all its a fine overnight rest stop.

Reviewed on Jan 17, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Central Missouri

Shore Thing - Lakefront for 12

1459 Ginger Rd, Lake Ozark, Mo 65049, Lake Ozark MO

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Central Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Central Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Central Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Central Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Central Missouri, and plan your next opulent escape.

Central Missouri hotels essential information

Accommodation	4,697 hotels
Lowest Price	$60
Highest Price	$169
Popular hotels	Ramada by Wyndham Columbia, voco The Tiger Hotel Columbia, MO by IHG, Lodge Of Four Seasons Golf Resort, Marina & Spa, Camden on the Lake Resort & Spa, Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel, Laci's Country Inn, Best Western Plus Columbia Inn, Super 8 by Wyndham Columbia Clark Lane