Explore 57 Luxury Hotels in Central Missouri

Name: Ramada by Wyndham Columbia
Price range: $72 total
Rating: 7.2

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Best Luxury Hotels in Central Missouri

Camden on the Lake Resort & Spa

2359 Bittersweet Road, Lake Ozark, MO

$156 nightly

$167 total

Oct 5 - Oct 6

Total with taxes and fees

This smoke-free resort features a full-service spa, a nightclub, and a marina. Traveling on business? Take advantage of the 24-hour business center and free ...

9/10 Wonderful! (1,001 reviews)

"Beautiful property....a little pricey, restaurant portions kinda small for the hefty prices...rooms where Beautiful and the beds were comfy!"

Reviewed on Sep 16, 2025

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

103 E 4th St, Sedalia, MO

Fully refundableReserve now, pay when you stay

$111 nightly

$126 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...

9/10 Wonderful! (553 reviews)

"The outside of this place looked nothing like what Expedia made it look like, however the inside was very cool and clean. Decorated very classy. What made me the most upset was that I did not see any extra charge on the initial Expedia page when booking this hotel for having a dog here. It told me ..."

Reviewed on Sep 22, 2025

voco, The Tiger Hotel, Columbia, MO by IHG

23 S 8th St, Columbia, MO

Fully refundable

$162 nightly

$184 total

Oct 5 - Oct 6

Total with taxes and fees

A nightclub, 3 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...

8.8/10 Excellent! (1,004 reviews)

"Fancy"

Reviewed on Sep 21, 2025

Best Western Plus Columbia Inn

2904 Clark Lane, Columbia, MO

Fully refundableReserve now, pay when you stay

$72 nightly

$81 total

Oct 9 - Oct 10

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...

8.8/10 Excellent! (1,191 reviews)

"traffic was very noisy outside"

Reviewed on Sep 26, 2025

Ramada by Wyndham Columbia

901 Conley Rd, Columbia, MO

Fully refundableReserve now, pay when you stay

$63 nightly

$72 total

Sep 30 - Oct 1

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

7.2/10 Good! (1,015 reviews)

"We were very pleased with the property. Well maintained, clean, comfortable beds and nice shower. I love it when breakfast has hot options like waffles, biscuits and gravy and scrambled eggs, as well as the fruit, cereal ,yogurt, sweets, coffee and juices. We will stop back here next time we come ..."

Reviewed on Sep 17, 2025

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr., Lake Ozark, MO

Fully refundableReserve now, pay when you stay

$109 nightly

$118 total

Oct 15 - Oct 16

Total with taxes and fees

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...

7.2/10 Good! (1,039 reviews)

Reviewed on Sep 22, 2025

Laci's Country Inn

410 N Vaughn St, Knob Noster, MO

$66 nightly

$72 total

Sep 29 - Sep 30

Total with taxes and fees

Free WiFi in public areas is available at this motel. Take advantage of the free self parking.

6.8/10 (159 reviews)

"The room was adequate sized and the tv worked well. Nice shower!"

Reviewed on Jul 6, 2025

Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln, Columbia, MO

Fully refundableReserve now, pay when you stay

$57 nightly

$64 total

Sep 30 - Oct 1

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.4/10 (987 reviews)

"Good location. prefer a place with a hot breakfast."

Reviewed on Sep 21, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Central Missouri

Latibe Retreat Lakefront Condo for 4 w/ Balcony & Pool Access

40 Lighthouse Road, Lake Ozark,, Missouri 65049, United States, Lake Ozark, MO

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10/10 Exceptional! (1 review)

Central Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Central Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Central Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Central Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Central Missouri, and plan your next opulent escape.

Central Missouri hotels essential information

Accommodation	4,653 hotels
Lowest Price	$64
Highest Price	$184
Popular hotels	Ramada by Wyndham Columbia, voco, The Tiger Hotel, Columbia, MO by IHG, Lodge Of Four Seasons Golf Resort, Marina & Spa, Camden on the Lake Resort & Spa, Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel, Laci's Country Inn, Best Western Plus Columbia Inn, Super 8 by Wyndham Columbia Clark Lane

Popular Luxury Stays in Central Missouri

5 Stars Luxury stays in Central Missouri

Luxury stays in Central Missouri with spa

Recent Central Missouri Hotel Reviews By Fellow Wanderers

Margaritaville Lake Resort Lake of the Ozarks

5 out of 5

Posted 8 hours ago

Travelocity Verified Review

"The spa was extremely friendly and helpful."

A verified traveler stayed at Margaritaville Lake Resort Lake of the Ozarks

Lodge Of Four Seasons Golf Resort, Marina & Spa

4 out of 5

Posted 6 days ago

Travelocity Verified Review

"Our stay was okay. The main lodge was lovely, the restaurants were quite good. In our room however, it was quite apparent that there were not pressure balancing valves in the shower. A number of times during my shower the water temperature would change from where I wanted it, to extremely hot or extremely cold. I also found it interesting that the hotel guest services did not know we had checked in. About 6 hours after we had checked in, someone from the desk called to ask us what time we would be arriving. Then didn't know what room they put us in. I found that a bit strange."

A verified traveler stayed at Lodge Of Four Seasons Golf Resort, Marina & Spa