Find a Hotel in Midtown
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Top hotels in Midtown

Drury Plaza Hotel St. Louis at the Arch
Very nice staff and great atmosphere. Quietest hotel room i have ever stayed in
Reviewed on Mar 10, 2026

Element St. Louis Midtown
The pool was too cold, but the hotel was clean and spacious!
Reviewed on Mar 11, 2026

21C Museum Hotel St Louis
Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones.
Reviewed on Mar 11, 2026

Pear Tree Inn St. Louis Near Union Station
Everyone and everything was amazing!! Definitely would recommend and stay again.
Reviewed on Mar 11, 2026

Clayton Plaza Hotel & Extended Stay
This is an older property, but very clean, comfortable, spacious and convenient to downtown Clayton. Parking was convenient and free on the weekend. Breakfast was better than average, with chef-made omelets and waffles.
Reviewed on Mar 11, 2026

Hyatt Regency St. Louis at The Arch
Very clean, bar staff was great, amazing restaurants-will be back!
Reviewed on Mar 11, 2026

Hollywood Casino & Hotel St. Louis
Only complaint is that we’re in 2026 and the tvs don’t come with Netflix
Reviewed on Mar 10, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hot tub had a strange film floating on top of the water and had chunks of hair in it. Linens were threadbare and cheap. Bathroom was very small. They charge $35.00 for early checkin even though the room was ready and we were 45 minutes early after traveling several hours. I’ve never been charged ...
Reviewed on Mar 11, 2026

Residence Inn by Marriott St Louis Downtown
Pulled out the sofa bed and stains all over. Third person (that I paid for was not able to sleep on the mattress). Took pictures showed to front desk and they took the pictures from my phone and said “ok” . Absolutely disgusting.
Reviewed on Mar 9, 2026
Midtown Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Midtown area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Midtown to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Midtown are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Midtown hotel reviews by fellow wanderers

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
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