Explore top 2026 4 Star Hotels in Clayton
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Top Clayton 4 Star hotels
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $120 total per night from Dec 8 to Dec 9
$120 total
Dec 8 - Dec 9
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.6/10 Excellent! (1,145 reviews)
Great
Reviewed on Dec 2, 2025
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Dec 21 to Dec 22
$111 total
Dec 21 - Dec 22
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.4/10 Very Good! (4,026 reviews)
The room was very spacious and clean! The staff was friendly and accommodating!
Reviewed on Dec 1, 2025
Hilton St. Louis Frontenac
1335 S Lindbergh Blvd Frontenac MO
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $130 total per night from Dec 13 to Dec 14
$130 total
Dec 13 - Dec 14
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (1,001 reviews)
The staff was extra helpful and went above and beyond even on a holiday that they would have preferred to have off.
Reviewed on Dec 3, 2025
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $153 total per night from Dec 29 to Dec 30
$153 total
Dec 29 - Dec 30
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,477 reviews)
Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area.
Reviewed on Dec 2, 2025
The Cheshire
6300 Clayton Rd Richmond Heights MO
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $153 total per night from Dec 7 to Dec 8
$153 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
8.6/10 Excellent! (1,000 reviews)
It was wonderful!
Reviewed on Dec 3, 2025
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $138 total per night from Dec 19 to Dec 20
$138 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,049 reviews)
Great hotel. Will definitely stay again.
Reviewed on Nov 25, 2025
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from Dec 7 to Dec 8
$113 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...
8.8/10 Excellent! (1,029 reviews)
Great
Reviewed on Dec 2, 2025
Live by Loews - St.Louis
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $177 total per night from Dec 7 to Dec 8
$177 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.2/10 Wonderful! (1,101 reviews)
Alright a bit pricey. Especially 40 dollars for parking. I'm still waiting on my deposit refund. Have not received it yet.
Reviewed on Nov 25, 2025
The Westin St. Louis
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $148 total per night from Dec 14 to Dec 15
$148 total
Dec 14 - Dec 15
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.4/10 Very Good! (1,010 reviews)
Great location
Reviewed on Dec 2, 2025
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $184 total per night from Dec 7 to Dec 8
$184 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...
8.4/10 Very Good! (1,007 reviews)
yes
Reviewed on Nov 23, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Clayton hotel reviews by fellow wanderers
21C Museum Hotel St Louis
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area. "
A verified traveler stayed at 21C Museum Hotel St Louis
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