Explore top 2026 4 Star Hotels in Clayton

Name: Ameristar Casino Resort and Spa
Price range: $226 total

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Clayton 4 Star hotels

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$118 nightly

$138 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$134 nightly

$158 total

Oct 10 - Oct 11

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (2,135 reviews)

"Wonderful vibrant bar and restaurant scene. Location is walkable, but we had to use the valet parking which was an additional cost of $55 per day since the hotel did not have parking."

Reviewed on Oct 8, 2026

The Cheshire

6300 Clayton Rd Richmond Heights MO

Fully refundableReserve now, pay when you stay

$148 nightly

$176 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8.8/10 Excellent! (1,000 reviews)

"The front staff was so welcoming and kind. The room so unique"

Reviewed on Oct 5, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Oct 18 - Oct 19

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

The Westin St. Louis

811 Spruce St St. Louis MO

$131 nightly

$153 total

Oct 18 - Oct 19

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$186 nightly

$219 total

Nov 1 - Nov 2

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$110 nightly

$130 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...

9.2/10 Wonderful! (1,805 reviews)

"I like hotel service but I wished for better dinner options."

Reviewed on Oct 8, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$122 nightly

$144 total

Oct 13 - Oct 14

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$193 nightly

$226 total

Oct 12 - Oct 13

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...

Don't see what you're looking for?

See all available properties in Clayton

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Clayton hotel reviews by fellow wanderers

Clayton Plaza Hotel & Extended Stay

5 out of 5

Posted 3 hours ago

Travelocity Verified Review

"The room was very nice and clean. Bed and pillows were so comfy."

A verified traveler stayed at Clayton Plaza Hotel & Extended Stay

Pear Tree Inn St. Louis Near Union Station

5 out of 5

Posted 8 hours ago

Travelocity Verified Review

"The food and drink options were perfect. This place is amazing for kids! Pet friendly! Walking distance to some great stuff. Our air stopped working at some point. That and the stuff splattered all over the curtains were the only negative. Will 100% use them in the future!"

A verified traveler stayed at Pear Tree Inn St. Louis Near Union Station