Explore top 2026 4 Star Hotels in Clayton

Name: 21C Museum Hotel St Louis
Price range: $173 total
Rating: 9

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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Jul 31 - Aug 1

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$199 nightly

$237 total

Aug 3 - Aug 4

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (1,998 reviews)

Reviewed on Jul 19, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$177 total

Aug 17 - Aug 18

Total with taxes and fees

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

8.8/10 Excellent! (1,002 reviews)

"Facility was clean but most of the staff weren't very helpful and were slow/no urgency, with the exception of the room cleaners who were very kind. Valet was the worst. The pool was closed for our entire stay because someone broke glass in it, which was irritating that glass would be allowed in the ..."

Reviewed on Jul 19, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$198 nightly

$234 total

Aug 3 - Aug 4

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

$159 nightly

$189 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,257 reviews)

"N/A"

Reviewed on Jul 19, 2026

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$140 nightly

$164 total

Aug 6 - Aug 7

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,004 reviews)

"We were given the wrong room 3 times. It was frustrating. Felt like they were understaffed and their systems not up to date.the rooms are nice but it’s difficult to ignore having to move rooms 4 times."

Reviewed on Jul 19, 2026

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$147 nightly

$171 total

Jul 26 - Jul 27

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,004 reviews)

"So to begin with they stuck us back in a room behind a ballroom in one of the back buildings. The room did not even have an exterior window. It was a very strange interior room and it had a window that looked out into the hallway so people walking by in the hallway could look in your room. Make matters ..."

Reviewed on Jul 19, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$115 nightly

$135 total

Aug 7 - Aug 8

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,118 reviews)

"Amazing hotel overall."

Reviewed on Jul 19, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$107 nightly

$126 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,977 reviews)

"Has to be one of the most beautiful hotels we have ever stayed at. All of the employees were amazing. And the best amenities. Pool, shuffle board, pool table and the 2nd floor is a beautiful art museum. Rooms were clean with plenty of room"

Reviewed on Jul 19, 2026

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Recent Clayton hotel reviews by fellow wanderers

Clayton Plaza Hotel & Extended Stay

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"The property was perfect in every way. They had the best breakfast I have had at a hotel! The staff was helpful and friendly.."

A verified traveler stayed at Clayton Plaza Hotel & Extended Stay

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

5 out of 5

Posted 3 hours ago

Travelocity Verified Review

"Oh my goodness—I absolutely fell in love with this hotel from the moment I arrived. What impressed me the most was the neighborhood. It is such a beautiful, peaceful, and charming area that I spent all of my free time simply walking around and enjoying the atmosphere. Everything is within walking distance—great restaurants, shopping, cafés, and anything else you might need. The neighborhood feels incredibly safe, clean, and family-friendly, and it was honestly my favorite part of the entire stay. The hotel itself was wonderful as well. It was very clean, and everyone on the staff was welcoming and kind. I especially want to mention the lovely woman working at the bar downstairs. She was incredibly friendly and would often offer me water while I was sitting in the lobby working on my laptop, which was such a thoughtful gesture. The rooms were clean, comfortable, and well maintained, and the towels were replaced regularly throughout my stay. I truly enjoyed everything about this hotel, and I already know that I’ll be staying here again the next time I visit."

A verified traveler stayed at Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Moonrise Hotel

4 out of 5

Posted 6 hours ago

Travelocity Verified Review

"The front desk man when we checked in was not friendly, even when given a compliment. He was in a rotten mood. The lobby reeked of weed all day and night Saturday. Thankfully it was gone Sunday. The hallway to the room was stinky and dark. The room was decently clean, but the bathroom walls had stains on them by the toilet, and the carpet wasn’t very well cleaned. The walls were dusty in the room. It seems Delmar is not doing as well as years past. We have stayed in the Moonrise many times over the last 15 or so years and it’s definitely not like it used to be in the area, which is sad! I’m not sure if we will come back."

A verified traveler stayed at Moonrise Hotel