Explore top 2026 4 Star Hotels in Clayton

Name: 21C Museum Hotel St Louis
Price range: $173 total

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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Jul 31 - Aug 1

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,152 reviews)

"Would stay here again"

Reviewed on Jul 20, 2026

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$197 nightly

$234 total

Jul 28 - Jul 29

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (2,001 reviews)

"Had a separate party on the rooftop...not considering guests would want to enjoy the rooftop. Gotta decide if u want to accommodate guests or host events. Party cleanup was a nuisance all night. Got comped...but still."

Reviewed on Jul 20, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$177 total

Aug 17 - Aug 18

Total with taxes and fees

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

8.8/10 Excellent! (1,002 reviews)

"Facility was clean but most of the staff weren't very helpful and were slow/no urgency, with the exception of the room cleaners who were very kind. Valet was the worst. The pool was closed for our entire stay because someone broke glass in it, which was irritating that glass would be allowed in the ..."

Reviewed on Jul 19, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$198 nightly

$234 total

Aug 3 - Aug 4

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

$159 nightly

$189 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$140 nightly

$164 total

Aug 6 - Aug 7

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$147 nightly

$171 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,006 reviews)

"Our stay was extremely disappointing. Upon arrival, we were assigned a second-floor villa room with no elevator, requiring us to carry all of our luggage up a flight of stairs. The hallways and stairwell were visibly dirty, creating a poor first impression. When we entered our room, we were immediately ..."

Reviewed on Jul 20, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$115 nightly

$135 total

Aug 7 - Aug 8

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,122 reviews)

"Not many breakfast options"

Reviewed on Jul 20, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$107 nightly

$126 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

9/10 Wonderful! (1,085 reviews)

"My husband and I booked this hotel as it seemed to be in a generally busy area and close to a bar that brought us into town for an event they were hosting. Upon arrival we were greeted by the valet who was incredibly kind - we then went upstairs to check in and were greeted by two lovely women who ..."

Reviewed on Jul 20, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.