Explore top 2026 4 Star Hotels in Clayton
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Top Clayton 4 Star hotels
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from May 10 to May 11
$173 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,772 reviews)
Location was wonderful, chris the bartender is fantastic
Reviewed on Apr 19, 2026
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $161 total per night from May 8 to May 9
$161 total
May 8 - May 9
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,022 reviews)
I love this hotel
Reviewed on Apr 19, 2026
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from May 8 to May 9
$143 total
May 8 - May 9
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
River City Casino & Hotel
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $130 total per night from Apr 22 to Apr 23
$130 total
Apr 22 - Apr 23
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,512 reviews)
We stayed at the hotel because the venue where we were attending a concert was attached to the hotel. It was nice to leave the concert and just head to your room instead of driving back down the road.
Reviewed on Apr 19, 2026
The Westin St. Louis
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $174 total per night from May 10 to May 11
$174 total
May 10 - May 11
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,004 reviews)
There was black long hair in the shower on the wall. There were 2 body was and 1 conditioner but NO shampoo. The lower shower head was facing the door so when I turned on the shower it sprayed me and all my stuff on the bathroom counter. I ordered room service and SPECIFICALLY said I had a gluten ...
Reviewed on Apr 18, 2026
Live by Loews - St.Louis
799 Clark ave St. Louis MO
$159 nightly
The price is $189 total per night from May 10 to May 11
$189 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,158 reviews)
Right in the middle of everything, very clean and check in was super easy.
Reviewed on Apr 19, 2026
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $226 total per night from Apr 26 to Apr 27
$226 total
Apr 26 - Apr 27
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...
8.4/10 Very Good! (1,003 reviews)
Staff was super rude as a frequent traveler we abide by all rules and signs posted when there is no rules or signs posted you treat your guest like trash for not knowing the rules that you never explained in any way.. worst vacation EVER . STAY ANYWHERE ELSE BUT HERE!
Reviewed on Apr 11, 2026
DoubleTree by Hilton St. Louis Forest Park
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $163 total per night from May 21 to May 22
$163 total
May 21 - May 22
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.2/10 Very Good! (1,003 reviews)
Clean rooms and safe and easy access parking garage.
Reviewed on Apr 16, 2026
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $136 total per night from May 10 to May 11
$136 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,270 reviews)
Great location, good pillows. The "air freshener" in the lobby was a bit strong. The stairs made me feel like I was in a horror movie, in part that was out of the hotel's control die to it being an old building (narrow, floor level changes, odd passage ways between floors) but the piles of debris ...
Reviewed on Apr 19, 2026
The Royal Sonesta Chase Park Plaza St. Louis
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $217 total per night from May 3 to May 4
$217 total
May 3 - May 4
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,006 reviews)
Nice clean and smooth walk to see other stuff
Reviewed on Apr 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Clayton hotel reviews by fellow wanderers
Pear Tree Inn St. Louis Airport
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Great Staff"
A verified traveler stayed at Pear Tree Inn St. Louis Airport
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