Explore top 2026 4 Star Hotels in Clayton

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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Jul 31 to Aug 1
$179 total
Jul 31 - Aug 1
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,152 reviews)
"Would stay here again"

Reviewed on Jul 20, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $234 total per night from Jul 28 to Jul 29
$234 total
Jul 28 - Jul 29
Total with taxes and fees
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (2,001 reviews)
"Had a separate party on the rooftop...not considering guests would want to enjoy the rooftop. Gotta decide if u want to accommodate guests or host events. Party cleanup was a nuisance all night. Got comped...but still."

Reviewed on Jul 20, 2026

Opens in a new windowMoonrise Hotel
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
1820 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $177 total per night from Aug 17 to Aug 18
$177 total
Aug 17 - Aug 18
Total with taxes and fees
This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...
8.8/10 Excellent! (1,002 reviews)
"Facility was clean but most of the staff weren't very helpful and were slow/no urgency, with the exception of the room cleaners who were very kind. Valet was the worst. The pool was closed for our entire stay because someone broke glass in it, which was irritating that glass would be allowed in the ..."

Reviewed on Jul 19, 2026

Opens in a new windowSt. Louis Union Station Hotel, Curio Collection by Hilton
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $234 total per night from Aug 3 to Aug 4
$234 total
Aug 3 - Aug 4
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
$159 nightly
The price is $189 total per night from Aug 3 to Aug 4
$189 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Opens in a new windowLive by Loews - St.Louis
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $164 total per night from Aug 6 to Aug 7
$164 total
Aug 6 - Aug 7
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
Opens in a new windowThe Westin St. Louis
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $171 total per night from Aug 9 to Aug 10
$171 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (1,006 reviews)
"Our stay was extremely disappointing. Upon arrival, we were assigned a second-floor villa room with no elevator, requiring us to carry all of our luggage up a flight of stairs. The hallways and stairwell were visibly dirty, creating a poor first impression. When we entered our room, we were immediately ..."

Reviewed on Jul 20, 2026

Opens in a new windowHilton St. Louis Frontenac
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $135 total per night from Aug 7 to Aug 8
$135 total
Aug 7 - Aug 8
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,122 reviews)
"Not many breakfast options"

Reviewed on Jul 20, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $126 total per night from Aug 3 to Aug 4
$126 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...
9/10 Wonderful! (1,085 reviews)
"My husband and I booked this hotel as it seemed to be in a generally busy area and close to a bar that brought us into town for an event they were hosting. Upon arrival we were greeted by the valet who was incredibly kind - we then went upstairs to check in and were greeted by two lovely women who ..."

Reviewed on Jul 20, 2026

Opens in a new windowAngad Arts Hotel St. Louis, Tapestry Collection by Hilton
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from Aug 9 to Aug 10
$173 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Opens in a new window21C Museum Hotel St Louis
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