Explore top 2026 4 Star Hotels in Clayton

Name: 21C Museum Hotel St Louis
Price range: $173 total
Rating: 9

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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Jul 31 - Aug 1

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$199 nightly

$237 total

Aug 2 - Aug 3

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (2,001 reviews)

"Had a separate party on the rooftop...not considering guests would want to enjoy the rooftop. Gotta decide if u want to accommodate guests or host events. Party cleanup was a nuisance all night. Got comped...but still."

Reviewed on Jul 20, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$177 total

Aug 17 - Aug 18

Total with taxes and fees

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

8.8/10 Excellent! (1,004 reviews)

"Great place, will definitely visit again. Everyone was really nice, and I really appreciated that all the restaurants and the aquarium were all within the same complex. So I never had to get into my car. You did go to the arch and the zoo, and those were no more than 6 to 8 minutes away. I would ..."

Reviewed on Jul 20, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

$198 nightly

$234 total

Aug 3 - Aug 4

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$140 nightly

$164 total

Aug 6 - Aug 7

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,006 reviews)

"I booked a deluxe room through Expedia, but the amenities did not match the description of what I paid for. When I went to the front desk, they were very polite but not accommodating. So we get To the room, it is a small room, that looks like it hasn't been dusted in months. Went to fill the Ice ..."

Reviewed on Jul 21, 2026

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$147 nightly

$171 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,006 reviews)

"Our stay was extremely disappointing. Upon arrival, we were assigned a second-floor villa room with no elevator, requiring us to carry all of our luggage up a flight of stairs. The hallways and stairwell were visibly dirty, creating a poor first impression. When we entered our room, we were immediately ..."

Reviewed on Jul 20, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$115 nightly

$135 total

Aug 7 - Aug 8

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,122 reviews)

"Not many breakfast options"

Reviewed on Jul 20, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$107 nightly

$126 total

Aug 3 - Aug 4

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Aug 13 - Aug 14

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,982 reviews)

"Great place"

Reviewed on Jul 21, 2026

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Recent Clayton hotel reviews by fellow wanderers

Clayton Plaza Hotel & Extended Stay

5 out of 5

Posted 5 hours ago

Travelocity Verified Review

"The breakfast staff and food were bangin"

A verified traveler stayed at Clayton Plaza Hotel & Extended Stay

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

5 out of 5

Posted 8 hours ago

Travelocity Verified Review

"Breakfast was great and staff was all helpful and friendly. The pool was down one night we were there which was a downside as that's one of the reasons we stay there. Our daughter loves the indoor/outdoor pool option. The hot tub wasn't very warm, it was more like bathwater which was also a downside. But we've stayed here several times and have always been happy with our choice. I understand things happen so we will stay again"

A verified traveler stayed at Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham