Explore top 2026 4 Star Hotels in Clayton

Name: River City Casino & Hotel
Price range: $126 total
Rating: 9.2

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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$140 nightly

$165 total

Jul 17 - Jul 18

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,239 reviews)

"The hotel was in a great location for baseball games and The Arch. It was very clean and very friendly staff. I highly recommend this hotel."

Reviewed on Jul 13, 2026

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

$157 nightly

$186 total

Jul 16 - Jul 17

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (2,015 reviews)

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Reviewed on Jul 10, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$198 nightly

$234 total

Aug 2 - Aug 3

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9/10 Wonderful! (1,026 reviews)

"I love staying at the Chase. Check in was easy. My room was clean and quiet. The furnishings were updated and the room was very comfortable. The staff is always friendly and helpful. It’s a great property."

Reviewed on Jul 12, 2026

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$100 nightly

$117 total

Jul 17 - Jul 18

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,008 reviews)

"We got a junior suite which was located in the Clayton building. It was clean and comfortable. Not extravagant, but nice. We did open the couch bed for my kids and the cover was dirty and there were no blankets or pillows. The front desk had someone to our room within about 20 minutes to put a brand ..."

Reviewed on Jul 12, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

$156 nightly

$186 total

Jul 20 - Jul 21

Total with taxes and fees

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

8.8/10 Excellent! (1,014 reviews)

"loved the entire atmosphere and how central the location was to things we wanted to do. Will definitely be staying again!"

Reviewed on Jul 12, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$122 nightly

$143 total

Jul 31 - Aug 1

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,122 reviews)

"the gentleman working the bar that evening was attentive, mixed a great cocktail."

Reviewed on Jul 13, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Jul 17 - Jul 18

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,250 reviews)

"This hotel was stunning- we had a view of the Ball diamond, the place was spotless, comfy and it was literally across the street from Busch stadium and a 5 minute walk to the Arch."

Reviewed on Jul 13, 2026

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$140 nightly

$164 total

Jul 19 - Jul 20

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,007 reviews)

"We have stayed here before and had the same delayed check-in experience. The lobby is full of guests waiting for a room an hour or more past check in time of 4pm. People have plans, cranky kids, need to change etc and this is unacceptable. Many properties have adapted the “no daily room service unless ..."

Reviewed on Jul 12, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,965 reviews)

"The hotel room was beautiful and very comfortable! The restaurant was amazing, museum was awesome and location was close to everything!"

Reviewed on Jul 12, 2026

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$108 nightly

$126 total

Aug 2 - Aug 3

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...

9.2/10 Wonderful! (1,665 reviews)

"Great staff and location. Went to a Cardinals game and tour of the arch."

Reviewed on Jul 12, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Clayton hotel reviews by fellow wanderers

Hyatt Regency St. Louis at The Arch

5 out of 5

Posted 2 hours ago

Travelocity Verified Review

"The hotel was in a great location for baseball games and The Arch. It was very clean and very friendly staff. I highly recommend this hotel."

A verified traveler stayed at Hyatt Regency St. Louis at The Arch

Drury Plaza Hotel St. Louis at the Arch

5 out of 5

Posted 2 hours ago

Travelocity Verified Review

"We had a great trip. I booked the hotel for two nights in one week but one at the beginning and one at the end. I was very impressed with the staff. Very polite and welcoming. Our room was fantastic. Clean and no visible issues. I am 'not sure if this is how ALL Drury's are but if so I think I have found my new hotel chain."

A verified traveler stayed at Drury Plaza Hotel St. Louis at the Arch

Pear Tree Inn St. Louis Near Union Station

5 out of 5

Posted 19 hours ago

Travelocity Verified Review

"We stayed 1 night and we enjoyed it. Location was perfect, walking distance to aquarium.Staff was helpful and friendly. They had complimentary snacks and drinks in the afternoon which was nice. We also forgot some stuff in the room and it was shipped to us quickly."

A verified traveler stayed at Pear Tree Inn St. Louis Near Union Station