Book Hotels in Commerce, MO

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Top Commerce hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 15 to Dec 16
$102 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife.

Reviewed on Dec 8, 2025

Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $131 total per night from Dec 21 to Dec 22
$131 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
We had a great stay, the hotel is nice and clean. The staff was very friendly and welcoming!

Reviewed on Dec 1, 2025

Opens in a new windowCourtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Dec 16 to Dec 17
$103 total
Dec 16 - Dec 17
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Clean big room, great staff

Reviewed on Nov 30, 2025

Opens in a new windowDrury Inn & Suites Sikeston, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
Fully refundable
$95 nightly
The price is $107 total per night from Dec 23 to Dec 24
$107 total
Dec 23 - Dec 24
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly.

Reviewed on Dec 3, 2025

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 15 to Dec 16
$102 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Very friendly staff and great breakfast

Reviewed on Dec 10, 2025

Opens in a new windowDrury Inn & Suites Cape Girardeau
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $109 total per night from Dec 14 to Dec 15
$109 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. ...
Helpful staff, clean room.

Reviewed on Nov 26, 2025

Opens in a new windowThe Riverview
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $91 total per night from Jan 7 to Jan 8
$91 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Nice room and pool and fitness room. Bed a little hard and lumpy, sink drain slow, shower water pressure low, musty smell in bathroom (curtain?), pool opened too late for my aerobic exercises (8am). (Prefer bacon to sausage)

Reviewed on Dec 1, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Dec 15 to Dec 16
$79 total
Dec 15 - Dec 16
Total with taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
Room could have been cleaner and no cups for coffee. Staff at front desk OUTSTANDING.

Reviewed on Dec 6, 2025

Opens in a new windowPear Tree Inn Cape Girardeau Near the Medical Center
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
Fully refundable
$70 nightly
The price is $84 total per night from Dec 14 to Dec 15
$84 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, ...
Very nice, spacious, loved the kitchen, the pool and the location.

Reviewed on Dec 9, 2025

Opens in a new windowCandlewood Suites Cape Girardeau by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Commerce?
Family vacations are where you make the best memories, but traveling with young ones can be stressful. These kid-friendly Commerce hotels offer perks that aim to keep visitors of all ages comfortable and happy: Your gang will enjoy staying at Serenity South -- Gardens, River-Views, and Refreshing Space. A water park and animal viewing activities are among the things that help make this property an appealing option. Otherwise, spend your evenings in Commerce at Newly re-listed downtown historic apartment. Make the most of a fireplace, internet access and more here.
Where can I find cheap hotels in Commerce?
At Travelocity you'll find really nice hotels in Commerce at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Commerce rather than in Commerce. We may find you even better rates, too.
How do I find the best Commerce hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Commerce then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Commerce?
The cheapest hotel in Commerce is $79. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Commerce?
There are 80 hotels in Commerce on Travelocity.
What are the best hotels in Commerce?
Commerce has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Commerce for you!
When is the best time to visit Commerce?
If you want the joy of a fun-filled trip in peak season, visit Commerce during May, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, October and December.
When is the cheapest time to stay in Commerce?
Based on historic data is usually the cheapest month to visit Commerce. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Commerce?
There are multiple hotels in Commerce that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Commerce. We have plenty of kid-friendly hotels in Commerce to choose from on Travelocity!
Why book a hotel in Commerce through Travelocity?
Because we have the top hotels in Commerce! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Commerce on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Commerce hotel reviews by fellow wanderers

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Very friendly staff and great breakfast"
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau

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