Book Hotels in Center, MO
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Top Center hotels

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
$235 nightly
The price is $248 total per night from Jun 15 to Jun 16
$248 total
Jun 15 - Jun 16
Total with taxes and fees
An outdoor pool is featured at this apartment, along with barbecue grills.
"Very nice and clean! So cozy and was perfect for our weekend at the lake!"
Reviewed on Aug 31, 2025

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Center MO
This cabin includes a garden and barbecue grills.
"We had a great time. Plenty of space, clean, nice outdoor areas. Would recommend."
Reviewed on Oct 28, 2025

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
$116 nightly
The price is $135 total per night from Jun 28 to Jun 29
$135 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"This hotel has one of the best breakfast options of any hotel we’ve stayed at. It is a nice and clean property. Our go to hotel when staying in Hannibal!"
Reviewed on Jun 7, 2026

Best Western On The River
401 North 3rd Street Hannibal MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $127 total per night from Jun 12 to Jun 13
$127 total
Jun 12 - Jun 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
"Staff was very friendly and welcoming."
Reviewed on Jun 9, 2026

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundable
$83 nightly
The price is $97 total per night from Jun 21 to Jun 22
$97 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"No clock in the room"
Reviewed on Jun 9, 2026

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundable
$102 nightly
The price is $117 total per night from Jun 28 to Jun 29
$117 total
Jun 28 - Jun 29
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Clean room, good hot breakfast, pool and hot tub were open until 11pm. Quite place. Our beds were comfortable. Great place to stay. Highly recommended."
Reviewed on Jun 9, 2026

Motel 6 Hannibal, MO
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $62 total per night from Jun 14 to Jun 15
$62 total
Jun 14 - Jun 15
Total with taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A fireplace in the lobby and a safe ...
"There was blood on the bathroom wall. It was okay for a less than a 24 hr stay for a truck pickup."
Reviewed on Jun 8, 2026

Days Inn by Wyndham Hannibal
4070 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $82 total per night from Jun 11 to Jun 12
$82 total
Jun 11 - Jun 12
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like full breakfast and WiFi ...
"We were looking forward to using the outdoor pool advertised, but it was out of use."
Reviewed on Jun 8, 2026

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.
Center MO
$286 nightly
The price is $302 total per night from Jun 11 to Jun 12
$302 total
Jun 11 - Jun 12
Total with taxes and fees
This apartment includes a garden and barbecue grills.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Best Western On The River
5 out of 5
Posted 17 hours ago
Travelocity Verified Review
"Staff was very friendly and welcoming. "
A verified traveler stayed at Best Western On The River
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