Book Hotels in Center, MO
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Top Center hotels

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
$118 nightly
The price is $137 total per night from Nov 29 to Nov 30
$137 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"R"
Reviewed on Oct 30, 2026

Cannon Dam Cabins
42526 Cabin Rd Perry MO
$103 nightly
The price is $109 total per night from Nov 6 to Nov 7
$109 total
Nov 6 - Nov 7
Total with taxes and fees
An indoor pool is featured at this cabin, along with free WiFi in public areas and a convenience store. A picnic area, laundry facilities, and barbecue grills ...
"Nice area, VERY convenient for our stay as family lived nearby. Room could definitely use some updates and TLC. But for our needs it was fine"
Reviewed on Oct 26, 2026

Best Western On The River
401 North 3rd Street Hannibal MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $116 total per night from Nov 8 to Nov 9
$116 total
Nov 8 - Nov 9
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
"Location was great!"
Reviewed on Nov 1, 2026

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
$204 nightly
The price is $215 total per night from Nov 5 to Nov 6
$215 total
Nov 5 - Nov 6
Total with taxes and fees
This apartment features barbecue grills.
"Everything has been excellent! The only thing to really complain about is the the refrigerator is awfully loud. And in the listing it shows a the picture of the pool in the back. There is no pool any longer."
Reviewed on Sep 20, 2026

Motel 6 Hannibal, MO
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $67 total per night from Nov 8 to Nov 9
$67 total
Nov 8 - Nov 9
Total with taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A fireplace in the lobby and a safe ...
"Always enjoy staying at this location. The rooms are neat and clean Good shower and TV! Only coffee available in the morning, but Hardees is 1/2 mile down the road (B & G is great !) . Great value for your travel dollars !"
Reviewed on Nov 4, 2026

Baymont by Wyndham Hannibal
4141 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$51 nightly
The price is $59 total per night from Dec 1 to Dec 2
$59 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features an indoor pool and a gym. There's fun for all ages with a children's pool and an arcade/game room, and families will appreciate the onsite ...
"Thanks for the hospitality. We enjoyed this stay very clean."
Reviewed on Nov 1, 2026

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.
Center MO
This apartment includes a garden and barbecue grills.

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundable
$74 nightly
The price is $87 total per night from Nov 29 to Nov 30
$87 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundable
$81 nightly
The price is $93 total per night from Nov 16 to Nov 17
$93 total
Nov 16 - Nov 17
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Motel 6 Hannibal, MO
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Always enjoy staying at this location. The rooms are neat and clean Good shower and TV! Only coffee available in the morning, but Hardees is 1/2 mile down the road (B & G is great !) . Great value for your travel dollars !"
A verified traveler stayed at Motel 6 Hannibal, MO
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