Book Hotels in Center, MO
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Top Center hotels

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
$195 nightly
The price is $206 total per night from Mar 6 to Mar 7
$206 total
Mar 6 - Mar 7
Total with taxes and fees
An outdoor pool is featured at this apartment, along with barbecue grills.
Very nice and clean! So cozy and was perfect for our weekend at the lake!
Reviewed on Aug 31, 2025

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Center MO
This cabin includes a garden and barbecue grills.
We had a great time. Plenty of space, clean, nice outdoor areas. Would recommend.
Reviewed on Oct 28, 2025

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
$110 nightly
The price is $127 total per night from Mar 29 to Mar 30
$127 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Staff was nice in evening when we checked in. The young man was informative, offered us cookies , recommended a great restaurant, Fiddlesticks. Lobby was colorful and eye catching but the room itself was so bland and depressing. There were 3 blk/wht noninteresting pictures above headboard. Otherwise ...
Reviewed on Feb 24, 2026

Best Western On The River
401 North 3rd Street Hannibal MO
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Mar 4 to Mar 5
$84 total
Mar 4 - Mar 5
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
Clean and quiet
Reviewed on Mar 3, 2026

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $83 total per night from Mar 29 to Mar 30
$83 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Driving to St. Louis bit stayed overnight in Hannibal. The Quality Inn is a great price and the employees are friendly and helpful. On the way home it was going to rain or snow so I stayed again. Different employees but they were nice too. The morning breakfast has a lot of food options and there ...
Reviewed on Mar 2, 2026

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $90 total per night from Mar 15 to Mar 16
$90 total
Mar 15 - Mar 16
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Clean room. Good location. Comfortable bed.
Reviewed on Feb 25, 2026

Motel 6 Hannibal, MO
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $63 total per night from Mar 6 to Mar 7
$63 total
Mar 6 - Mar 7
Total with taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A snack bar/deli and a fireplace in ...
Very clean room and great customer service. No breakfast but fresh coffee at 6am
Reviewed on Feb 18, 2026

Baymont by Wyndham Hannibal
4141 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $73 total per night from Mar 8 to Mar 9
$73 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features an indoor pool and a gym. There's fun for all ages with a children's pool and an arcade/game room, and families will appreciate the onsite ...
It was ok as a hotel stay for over night, even tho baymont took it over, it isnt any better. The owner i think lives there, there wasnt any towels in our room. I didnt get a friendly vibe from them at all.
Reviewed on Feb 23, 2026

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.
Center MO
$286 nightly
The price is $302 total per night from Mar 4 to Mar 5
$302 total
Mar 4 - Mar 5
Total with taxes and fees
This apartment features barbecue grills.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Quality Inn & Suites Hannibal West
5 out of 5
Posted 4 days ago
Travelocity Verified Review
"The room was really nice "
A verified traveler stayed at Quality Inn & Suites Hannibal West
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