Explore top 2025 4 Star Hotels in Seneca

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Next weekend
In two weeks

Top Seneca 4 Star hotels

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $210 total per night from Sep 30 to Oct 1
$210 total
Sep 30 - Oct 1
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
9.6/10 Exceptional! (689 reviews)
"Everything! Beautiful, convenient and wonderful staff!"

Reviewed on Sep 24, 2025

Opens in a new windowThe Shepherd Hotel Downtown Clemson
The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy, Clemson, SC
$179 nightly
The price is $199 total per night from Oct 6 to Oct 7
$199 total
Oct 6 - Oct 7
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
9.6/10 Exceptional! (542 reviews)
"very nice"

Reviewed on Sep 15, 2025

Opens in a new windowThe Abernathy of Clemson
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4 out of 5
621 S Mechanic St, Pendleton, SC
$161 nightly
The price is $178 total per night from Oct 3 to Oct 4
$178 total
Oct 3 - Oct 4
Total with taxes and fees
This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...
9.8/10 Exceptional! (74 reviews)
"Excellent property with spacious rooms and a great front porch with rocking chairs to relax in. Fabulous breakfast every day. But most important was the staff. Angela and Micheal were very welcoming and ready to help with anything you might need. Would definitely return."

Reviewed on Sep 2, 2025

Opens in a new windowLiberty Hall Bed and Breakfast
Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson

4 out of 5
7008 SC-187, Anderson, SC
$266 nightly
The price is $295 total per night from Oct 2 to Oct 3
$295 total
Oct 2 - Oct 3
Total with taxes and fees
Stay at this 4-star vacation home in Anderson. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Woodburn and Agricultural Museum are ...
Opens in a new windowLake Hartwell Frank Howard Home Clemson
Southern Sunshine Retreat

Southern Sunshine Retreat

4 out of 5
901 Huntington Rd, Easley, Sc 29642, Usa, Easley, SC
This vacation home includes free WiFi in public areas and barbecue grills.
Opens in a new windowSouthern Sunshine Retreat
Belvedere

Belvedere

4 out of 5
302 Alameda Ln, Anderson, SC
This vacation home features barbecue grills. Take advantage of the free self parking.
8/10 Very Good! (1 review)
Ok but…
"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why???"

Reviewed on Feb 9, 2025

Opens in a new windowBelvedere
228 Lakeland

228 Lakeland

4 out of 5
228 Lakeland Dr, Anderson, SC
This vacation home features barbecue grills. Take advantage of the free self parking.
Opens in a new window228 Lakeland
Pendleton

Pendleton

4 out of 5
119 Weaver Way, Pendleton, SC
This vacation home features barbecue grills. Take advantage of the free self parking.
Opens in a new windowPendleton
Don't see what you're looking for?
See all available properties in Seneca
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Seneca

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Seneca 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Seneca will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Seneca, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Seneca hotel reviews by fellow wanderers