Hotels on the Lake in Upstate South Carolina from $63
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Top Upstate South Carolina Hotels on the Lake

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks
Seneca SC
This vacation home features a garden, laundry facilities, and barbecue grills. There's fun for all ages with a playground and an arcade/game room.

Fall fun at the cabin! Convenient to Lake Keowee and Clemson
Seneca SC
A gym is featured at this cabin, along with a garden and laundry facilities. Barbecue grills are provided for your convenience.

Hampton Inn Clemson-University Area
851 Tiger Blvd Clemson SC
$110 nightly
The price is $122 total per night
$122 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...

Best Western Seneca-Clemson
511 Bypass Highway 123 Seneca SC
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $103 total per night
$103 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business ...

Studio 6 Greenville, SC - I-85 Near Downtown
12 Impact Dr Greenville SC
Free Cancellation
Reserve now, pay when you stay
$57 nightly
The price is $63 total per night
$63 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Laundry facilities and barbecue grills are also provided.

Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
$71 nightly
The price is $79 total per night
$79 total
Dec 1 - Dec 2
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...

Days Inn by Wyndham Clemson
1387 Tiger Blvd Clemson SC
$85 nightly
The price is $94 total per night
$94 total
Nov 8 - Nov 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

Clemson University's James F. Martin Inn
240 Madren Center Drive Clemson SC
$139 nightly
The price is $154 total per night
$154 total
Nov 30 - Dec 1
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center ...

Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
$119 nightly
The price is $131 total per night
$131 total
Dec 3 - Dec 4
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
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See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Upstate South Carolina hotels essential information
Accommodation | 3,083 hotels |
|---|---|
Lowest Price | $63 |
Highest Price | $154 |
Popular hotels | 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks, Clemson University's James F. Martin Inn, Hampton Inn & Suites Seneca-Clemson Area, Best Western Seneca-Clemson, Days Inn by Wyndham Seneca / Clemson Area, Fall fun at the cabin! Convenient to Lake Keowee and Clemson, Hampton Inn Clemson-University Area, Days Inn by Wyndham Clemson, Studio 6 Greenville, SC - I-85 Near Downtown |
Recent Upstate South Carolina hotel reviews by fellow wanderers

Best Western Plus Greenville I-385 Inn & Suites
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"This property is ALWAYS clean and very well maintained. It is our go to location in Greenville SC."
A verified traveler stayed at Best Western Plus Greenville I-385 Inn & Suites
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