Hotels on the Lake in Santee from $81
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Santee Hotels on the Lake

Hampton Inn Santee-I-95
9060 Old Number Six Hwy, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$135 nightly
The price is $150 total per night
$150 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Guests will appreciate free perks like free self parking and WiFi in public areas. A 24-hour business ...

Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$114 nightly
The price is $126 total per night
$126 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...

Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $118 total per night
$118 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...

Red Roof Inn Santee
9091 Old Hwy 6, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$73 nightly
The price is $81 total per night
$81 total
Oct 1 - Oct 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santee hotels essential information
Accommodation | 289 hotels |
---|---|
Lowest Price | $81 |
Highest Price | $150 |
Popular hotels | Red Roof Inn Santee, Best Western Plus Santee Inn, Hampton Inn Santee-I-95, Comfort Inn & Suites Santee |
Recent Santee hotel reviews by fellow wanderers

Hampton Inn Santee-I-95
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"All good "
A verified traveler stayed at Hampton Inn Santee-I-95
Explore More Ways to Travel with Travelocity
Explore More Ways to Travel with Travelocity
- Winery Hotels in Columbia
- Beach Resorts & in Manning
- Cheap Hotels in Manning
- Convention Center Hotels in Manning
- Hotels with Pools in Manning
- Hotels with Bar in Manning
- Pet Friendly Hotels in Manning
- Cheap Hotels in St. George
- Hotels with Balconies in St. George
- Luxury Hotels in St. George
- Pet Friendly Hotels in St. George
- Cottages in Vance
- Vance Hotels
- Providence Hotels
- Hotels with Hot Tubs in Sumter
- Pet Friendly Hotels in Sumter
- Hotels with Suites in South Carolina
- Hotels with Early Check-in in South Carolina
- Hotels with Pools in South Carolina
- Hotels with Childcare in South Carolina
- Hotels with a Gym in South Carolina
- Hotels with Free Parking in South Carolina
- Hotels with Tennis Courts in South Carolina
- Hotels on the Lake in South Carolina
- Hotels on the River in South Carolina
- Romantic Getaways & Hotels in South Carolina
- Spa Resorts & in South Carolina
- Pet Friendly Hotels in Orangeburg County
- Hotels with Airport Transfers in Myrtle Beach
- Hotels with Pools in Myrtle Beach
- Hotels with Tennis Courts in Myrtle Beach
- Hotels near Santee Cooper Country Club
- Hotels near Santee State Park
- Adults Only Resorts & in Orangeburg
- Beach Resorts & in Orangeburg
- Cheap Hotels in Orangeburg
- Convention Center Hotels in Orangeburg
- Kid Friendly Hotels in Orangeburg
- Golf Resorts & in Orangeburg
- Historic Hotels in Orangeburg
- Hotels with Pools in Orangeburg
- Hotels with Bar in Orangeburg
- Hotels with Hot Tubs in Orangeburg
- Hotels with an Indoor Pool in Orangeburg
- Luxury Hotels in Orangeburg
- Pet Friendly Hotels in Orangeburg
- Romantic Getaways & Hotels in Orangeburg
- Spa Resorts & in Orangeburg
- B&B in Summerton
- Cabins in Summerton
- Condos in Summerton
- Cottages in Summerton
- Extended Stay Hotels in Summerton
- Convention Center Hotels in Summerton
- Pet Friendly Hotels in Summerton
- Red Roof Inn Hotels in Summerton
- Summerton Hotels
- Motels in Summerton
- Vacation Homes in Summerton
- Hotels near Santee National Golf Club
- Apartments in Eutawville
- Cabins in Eutawville
- Condos in Eutawville
- Cottages in Eutawville
- Eutawville Hotels
- Motels in Eutawville
- Vacation Homes in Eutawville
- All Inclusive Resorts & in French Quarter
- Golf Resorts & in French Quarter
- Hotels with Early Check-in in French Quarter
- Hotels with Air Conditioning in French Quarter
- Spa Resorts & in French Quarter
- 3 Star Hotels in Elloree
- 5 Star Hotels in Elloree
- Elloree Hotels
- Motels in Elloree
- Vacation Homes in Elloree
- Rv Parks in Elloree
- Apartments in Holly Hill
- Holly Hill Hotels
- Vacation Homes in Holly Hill
- Hotels with a Lazy River in Charleston
- Hotels with a Gym in Charleston
- Hotels with Free Parking in Charleston
- Hotels with Kitchenettes in Charleston
- Winery Hotels in Charleston