Book Hotels in Santa Cruz

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Apr 17 - Apr 18
Tomorrow
Apr 18 - Apr 19
This weekend
Apr 17 - Apr 19
Next weekend
Apr 24 - Apr 26

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Santa Cruz hotels

Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia

4 out of 5
Cll 10A No. 34 - 11 Medellín Antioquia
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $121 total per night from Apr 29 to Apr 30
$121 total
Apr 29 - Apr 30
A full-service spa, 3 restaurants, and 2 hot tubs are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...
Great location.

Reviewed on Apr 14, 2026

Opens in a new windowDiez Hotel Categoria Colombia
Heiss Hotel By Jalo

Heiss Hotel By Jalo

4 out of 5
1460 Cra. 43F Medellín Antioquia
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $72 total per night from May 12 to May 13
$72 total
May 12 - May 13
This hotel features an outdoor pool and a gym. Relax with a drink at the poolside bar and enjoy perks like free WiFi. A garden is provided and the front desk ...
Clean

Reviewed on Apr 17, 2026

Opens in a new windowHeiss Hotel By Jalo
Hunters By Jalo

Hunters By Jalo

4 out of 5
3621 Cl 10 Medellín Antioquia
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $64 total per night from Apr 20 to Apr 21
$64 total
Apr 20 - Apr 21
This hotel features a restaurant, free WiFi in public areas, and luggage storage. Staff at the 24-hour front desk can provide around-the-clock assistance.
A super nice stay in the hearth of Poblado. Near everything.

Reviewed on Apr 13, 2026

Opens in a new windowHunters By Jalo
Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo

4 out of 5
Carrera 41 # 10 - 37 Medellín Medellín
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $77 total per night from May 5 to May 6
$77 total
May 5 - May 6
This hotel features a restaurant, free WiFi in public areas, and a safe deposit box. The front desk is staffed around-the-clock and concierge services are on ...
Clean room and everything was amazing

Reviewed on Apr 17, 2026

Opens in a new windowHashtag 98 Hotel By Jalo
NH Collection Medellín Royal

NH Collection Medellín Royal

5 out of 5
Carrera 42 No 5 Sur 130 Medellín Antioquia
$110 nightly
The price is $110 total per night from May 16 to May 17
$110 total
May 16 - May 17
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
Great Place.The beds are a little to hard but other than that. Is great

Reviewed on Apr 15, 2026

Opens in a new windowNH Collection Medellín Royal
Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

4 out of 5
# 37-40 Calle 9A Medellín
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $69 total per night from Apr 18 to Apr 19
$69 total
Apr 18 - Apr 19
This smoke-free hotel features 2 restaurants, a bar/lounge, and an outdoor pool. WiFi in public areas is free. Dry cleaning and luggage storage are also ...
I love the hotel the room comfortable clean and beautiful the view amazing location perfect the price super economic . My next trip to the same hotel!! Thank you

Reviewed on Apr 17, 2026

Opens in a new windowCalle Flora Hotel by Jalo
Dann Carlton Medellin Hotel

Dann Carlton Medellin Hotel

4.5 out of 5
Carrera 43a No.7-50, Avenida El Poblado Medellín Antioquia
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $77 total per night from Apr 26 to Apr 27
$77 total
Apr 26 - Apr 27
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free ...
No muy limpio , ya medio deteriorado.

Reviewed on Apr 16, 2026

Opens in a new windowDann Carlton Medellin Hotel
Blues Suites Medellin

Blues Suites Medellin

4 out of 5
Cra 29C #1a sur 80 Medellín Antioquia
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $97 total per night from May 3 to May 4
$97 total
May 3 - May 4
A full-service spa and a restaurant are featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas and airport ...
The breakfast was super good!!!

Reviewed on Apr 16, 2026

Opens in a new windowBlues Suites Medellin
Hotel Dorado La 70

Hotel Dorado La 70

4 out of 5
Carrera 70 No 44 B-66 Medellín
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $61 total per night from Apr 26 to Apr 27
$61 total
Apr 26 - Apr 27
This traditional hotel features a casino, a nightclub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
Excellent service. Bar at the top was very pleasant with an excellent view and friendly staff. Rooms were very clean. Breakfast good.

Reviewed on Apr 16, 2026

Opens in a new windowHotel Dorado La 70
Don't see what you're looking for?
See all available properties in Santa Cruz
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Santa Cruz?
Family getaways are where you make the best memories, but it's no secret that traveling with little ones can be demanding. These kid-friendly Santa Cruz hotels come with perks that aim to keep young and old alike comfortable and happy: Settle in at Casa Grande Medellin Comuna 1. It comes with a king bed, pet-friendly facilities and a talent for making families feel welcome. Apartment is another great choice. After a big day of exploring, come home to your comfy room and amenities like pet-friendly facilities and internet access.
Where can I find cheap hotels in Santa Cruz?
At Travelocity you'll find really nice hotels in Santa Cruz at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Santa Cruz rather than in Santa Cruz. We may find you even better rates, too.
How do I find the best Santa Cruz hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Santa Cruz then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Santa Cruz?
The cheapest hotel in Santa Cruz is $61. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Santa Cruz?
There are 4,291 hotels in Santa Cruz on Travelocity.
What are the best hotels in Santa Cruz?
Santa Cruz has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Santa Cruz for you!
When is the best time to visit Santa Cruz?
If you want the joy of a fun-filled trip in peak season, visit Santa Cruz during March, May and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as September, November and December.
When is the cheapest time to stay in Santa Cruz?
Based on historic data is usually the cheapest month to visit Santa Cruz. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Santa Cruz?
There are multiple hotels in Santa Cruz that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Santa Cruz. We have plenty of kid-friendly hotels in Santa Cruz to choose from on Travelocity!
Why book a hotel in Santa Cruz through Travelocity?
Because we have the top hotels in Santa Cruz! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Santa Cruz on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Santa Cruz hotel reviews by fellow wanderers

Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

5 out of 5
Posted 13 hours ago
Travelocity Verified Review
"I love the hotel the room comfortable clean and beautiful the view amazing location perfect the price super economic . My next trip to the same hotel!! Thank you"
A verified traveler stayed at Calle Flora Hotel by Jalo
Calle Flora Hotel by Jalo

Explore More Ways to Travel with Travelocity