Explore 7 Luxury Hotels in Orangeburg

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Orangeburg

Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd Orangeburg SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $88 total per night from Jun 2 to Jun 3
$88 total
Jun 2 - Jun 3
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
8.2/10 Very Good! (1,003 reviews)
"Bed was clean and comfortable, wifi didn’t work and was supposed to be reset, still didn’t work. Bathroom was tired looking."

Reviewed on May 14, 2026

Opens in a new windowTravelodge by Wyndham Orangeburg
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

221 Britain St Santee SC
Fully refundable
$97 nightly
The price is $108 total per night from Jun 21 to Jun 22
$108 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
8/10 Very Good! (1,007 reviews)
"Clean room nice respect staf"

Reviewed on May 28, 2026

Opens in a new windowComfort Inn & Suites Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Jun 2 to Jun 3
$89 total
Jun 2 - Jun 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
8/10 Very Good! (1,468 reviews)
"No water pressure, the room was old looking,the lock on the door didn't work, and the furniture was very worn and stained"

Reviewed on May 30, 2026

Opens in a new windowBaymont by Wyndham Santee
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

123 Mall Street Santee SC
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $82 total per night from Jun 8 to Jun 9
$82 total
Jun 8 - Jun 9
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
6.4/10 (562 reviews)
"Nice"

Reviewed on May 19, 2026

Opens in a new windowRamada by Wyndham Santee I-95
Econo Lodge Santee

Econo Lodge Santee

9112 Old 6 Highway Santee SC
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $84 total per night from Jun 14 to Jun 15
$84 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, luggage storage, and barbecue grills are also on offer.
6.4/10 (314 reviews)
"Expensive for the quality of the place!"

Reviewed on May 3, 2026

Opens in a new windowEcono Lodge Santee
Baymont by Wyndham Orangeburg North

Baymont by Wyndham Orangeburg North

3583 Saint Matthews Rd Orangeburg SC
Fully refundableReserve now, pay when you stay
$50 nightly
The price is $55 total per night from Jun 10 to Jun 11
$55 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
6/10 (1,002 reviews)
"Breakfast was not good. Prepackaged croissants for breakfast. Just plain weal"

Reviewed on May 31, 2026

Opens in a new windowBaymont by Wyndham Orangeburg North
Red Roof Inn Santee

Red Roof Inn Santee

9091 Old Hwy 6 Santee SC
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $70 total per night from Jun 4 to Jun 5
$70 total
Jun 4 - Jun 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Opens in a new windowRed Roof Inn Santee
Don't see what you're looking for?
See all available properties in Orangeburg
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Orangeburg Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Orangeburg luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Orangeburg to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Orangeburg will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Orangeburg, and plan your next opulent escape.


Orangeburg hotels essential information

Accommodation
255 hotels
Lowest Price
$55
Highest Price
$108
Popular hotels
Travelodge by Wyndham Orangeburg, Red Roof Inn Santee, Comfort Inn & Suites Santee, Baymont by Wyndham Orangeburg North, Baymont by Wyndham Santee, Ramada by Wyndham Santee I-95, Econo Lodge Santee

Popular Luxury Stays in Orangeburg

Recent Orangeburg Hotel Reviews By Fellow Wanderers

Explore More Ways to Travel with Travelocity