Explore 4 Luxury Hotels in Greenville Downtown

Name: Hyatt Regency Greenville
Price range: $153 total
Rating: 8.6

Best Luxury Hotels in Greenville Downtown

The Westin Poinsett Greenville

120 South Main St Greenville SC

Fully refundableReserve now, pay when you stay

$159 nightly

$175 total

Dec 22 - Dec 23

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...

9.2/10 Wonderful! (1,003 reviews)

Easy check in and rooms were clean. The hotel has an old charm to it and is in a great location.

Reviewed on Nov 24, 2025

Hampton Inn & Suites Greenville-Downtown-RiverPlace

171 Riverplace Greenville SC

Fully refundableReserve now, pay when you stay

$129 nightly

$142 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

This hotel features a 24-hour gym and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet ...

9.2/10 Wonderful! (1,000 reviews)

Really great location and staff was kind. However, the breakfast did not any bread/waffle/bagel nor cereal options for gluten free. The staff said the oatmeal was gluten free but it isn't because I checked the brand.

Reviewed on Dec 2, 2025

Holiday Inn Express & Suites Greenville - Downtown by IHG

407 North Main Street Greenville SC

Fully refundable

$103 nightly

$114 total

Dec 20 - Dec 21

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

8.8/10 Excellent! (1,014 reviews)

Front desk Nathaniel was absolutely fabulous. professional kind made you feel welcome and appreciate as a guest. Thank you for that. Every staff member was very pleasant. The rooms nice clean, normal hotel rooms. My only complaint and recommendation is they keep the breakfast open to 10 AM especially ...

Reviewed on Nov 30, 2025

Hyatt Regency Greenville

220 N Main St Greenville SC

Fully refundableReserve now, pay when you stay

$140 nightly

$153 total

Dec 21 - Dec 22

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (1,000 reviews)

Great location and beautiful, lively lobby. The only negative was the breakfast buffet at the adjoining restaurant. The food on the buffet was not great, and the buffet was the only option. We would have preferred a menu option as well.

Reviewed on Dec 2, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Greenville Downtown

Doubletree By Hilton Greenville Airport

125 The Parkway Greer SC

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Greenville Downtown Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Greenville Downtown luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Greenville Downtown to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Greenville Downtown will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Greenville Downtown, and plan your next opulent escape.

Greenville Downtown hotels essential information

Accommodation	1,173 hotels
Lowest Price	$114
Highest Price	$175
Popular hotels	The Westin Poinsett Greenville, Hyatt Regency Greenville, Hampton Inn & Suites Greenville-Downtown-RiverPlace, Holiday Inn Express & Suites Greenville - Downtown by IHG

Popular Luxury Stays in Greenville Downtown

5 Stars Luxury stays in Greenville Downtown

Luxury stays in Greenville Downtown with spa

Recent Greenville Downtown Hotel Reviews By Fellow Wanderers

Hyatt Regency Greenville

5 out of 5

Posted 3 days ago

Travelocity Verified Review

"Great location and beautiful, lively lobby. The only negative was the breakfast buffet at the adjoining restaurant. The food on the buffet was not great, and the buffet was the only option. We would have preferred a menu option as well."

A verified traveler stayed at Hyatt Regency Greenville

Hampton Inn & Suites Greenville-Downtown-RiverPlace

5 out of 5

Posted 4 days ago

Travelocity Verified Review

"From the onset, our stay was amazing. The hotel was extremely clean, the staff so very, very nice and attentive. Our room was super comfortable and very clean. The morning breakfast was terrific! And, all this in walking distance from beautiful downtown Greenville. Definitely will stay here again!!"

A verified traveler stayed at Hampton Inn & Suites Greenville-Downtown-RiverPlace

Holiday Inn Express & Suites Greenville - Downtown by IHG

5 out of 5

Posted 5 days ago

Travelocity Verified Review

"Front desk Nathaniel was absolutely fabulous. professional kind made you feel welcome and appreciate as a guest. Thank you for that. Every staff member was very pleasant. The rooms nice clean, normal hotel rooms. My only complaint and recommendation is they keep the breakfast open to 10 AM especially on weekends. They close at 9:30 other than that I will be back. Great location park your car for your stay to all the attractions downtown. I repeat do not try to drive downtown look for parking by the time you do your vacation is over. walk a block and a half to all the stores and restaurants take a break and after that enjoy Reed River. "

A verified traveler stayed at Holiday Inn Express & Suites Greenville - Downtown by IHG