Find & Compare 40 Adults-Only Hotels & Resorts in Florida Keys With Rates at from $167

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Top Adults Only Resorts in Florida Keys

 Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

1118 Fleming St Key West FL
$245 nightly
The price is $276 total per night from Aug 1 to Aug 2
$276 total
Aug 1 - Aug 2
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A business center, ...
9.8/10 Exceptional! (152 reviews)
"The staff was amazing, the whole property is well maintained, the accommodations are first class, we had a wonderful time and look forward to returning 😁"

Reviewed on Jul 26, 2026

Opens in a new window Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only

819 Simonton Street Key West FL
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $206 total per night from Aug 3 to Aug 4
$206 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Enjoy the free self-serve breakfast each morning. Self parking, a terrace, and a garden are also offered.
9.2/10 Wonderful! (1,000 reviews)
"Great spot. Close to Duval. Basic breakfast for free."

Reviewed on Jul 27, 2026

Opens in a new windowParadise Inn Key West - Adults Only
Heron House - Adult Only

Heron House - Adult Only

512 Simonton St Key West FL
$149 nightly
The price is $167 total per night from Aug 3 to Aug 4
$167 total
Aug 3 - Aug 4
Total with taxes and fees
This bed & breakfast features an outdoor pool and a rooftop terrace. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A ...
9.2/10 Wonderful! (1,167 reviews)
"Lovely property! Convenient to Duvall St., Sloppy Joe’s and Mallory Sq. Each room decorated island style, bed very comfy, lots of room, etc. Will stay here again."

Reviewed on Jul 31, 2026

Opens in a new windowHeron House - Adult Only
The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

413 Applerouth Lane Key West FL
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $172 total per night from Aug 4 to Aug 5
$172 total
Aug 4 - Aug 5
Total with taxes and fees
This guesthouse features an outdoor pool and a hot tub. Enjoy the free continental breakfast each morning. Self parking, a terrace, and a garden are also ...
9/10 Wonderful! (1,000 reviews)
"This place was very clean and the staff was friendly, and helpful in booking activities! The breakfast was solid and they have Starbucks coffee free all day long. Would comeback and stay again"

Reviewed on Jul 27, 2026

Opens in a new windowThe Cabana Inn Key West - Adults Only
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

525 United Street Key West FL
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $171 total per night from Aug 5 to Aug 6
$171 total
Aug 5 - Aug 6
Total with taxes and fees
This hotel's 2 outdoor pools and hot tub are among the featured amenities. Enjoy the free continental breakfast each morning. Self parking, a coffee shop, and ...
8.4/10 Very Good! (1,411 reviews)
"Room is clean but small"

Reviewed on Jul 31, 2026

Opens in a new windowThe Southernmost Inn - Adults Only
Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive

1400 Duval Street Key West FL
$272 nightly
The price is $306 total per night from Aug 16 to Aug 17
$306 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Guests will appreciate free perks like continental breakfast and WiFi in public areas. Self ...
Opens in a new windowSouthernmost House - Adult Exclusive
The Independent Inn - Locally Owned

The Independent Inn - Locally Owned

412 Frances St Key West FL
$152 nightly
The price is $167 total per night from Aug 9 to Aug 10
$167 total
Aug 9 - Aug 10
Total with taxes and fees
This guesthouse features an outdoor pool and a rooftop terrace. WiFi in public areas is free. A terrace, a garden, and luggage storage are also on offer.
Opens in a new windowThe Independent Inn - Locally Owned
Casa Morada

Casa Morada

136 Madeira Road Islamorada FL
$330 nightly
The price is $371 total per night from Aug 10 to Aug 11
$371 total
Aug 10 - Aug 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Spend a day at the beach kayaking, or relax with sun loungers and beach ...
Opens in a new windowCasa Morada
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Book a stay at the best Florida Keys adult only resorts

How can I find the best adults-only resorts in Florida Keys?


Enter your travel dates, hit search, and click on the hotel resorts filter to compare prices, ratings, and genuine customer reviews from fantastic Florida Keys adults-only resorts.


How can I find adults-only all-inclusive resorts in Florida Keys?


Click on our all-inclusive filter to see the latest deals on an enticing selection of adults only all-inclusive resorts and hotels in Florida Keys. It’s that simple.


How much do Florida Keys adults-only hotels cost?


Prices start at just $167 a night, going up to $371 for luxury adults-only accommodation. Prices and availability are subject to change. Additional terms may apply.


When is the best time for an adult getaway to Florida Keys?


In , there’s loads going on and a great atmosphere. A super-popular time for a romantic adult-only getaway is Valentine's weekend in Florida Keys.


Are there any cheap couples’ resorts in Florida Keys?


To find cheaper accommodation in Florida Keys, order your search results by lowest price to see wallet friendlier stays first. You can use the budget filter, too. If your travel dates are flexible, visit in , when prices tend to be lower.


How can I find adults-only spa resorts in Florida Keys?


Click on our spa filter under amenities on your search results page to see the spa resorts and hotels that whisk you away to a world of pampering and relaxation—just as you deserve.


What are some great things to do in Florida Keys for adults?


Whether you’re taking a break from work, family, kids, or just the rigor of daily life, an adults-only break is the perfect opportunity to relax. Explore Florida Keys by booking an excursion, chill by the pool with your loved one, and enjoy romantic cocktails and evening meals by candlelight.


How can I find the best Florida Keys adults-only hotel deals?


With Travelocity, you can see the latest deals simply by entering your travel dates and hitting search. Use the budget filter to narrow down accommodation in your price range, check out our customer ratings to compare deals, too, and when you download the free Travelocity appOpens in a new window, you also get great member discounts.  


Can I get free cancellation on my adults only hotel in Florida Keys?


Many adults only hotels in Florida Keys offer free cancellation. Canceling a booking is simple: Log into your My TripsOpens in a new window page and go to your itinerary to see your options. Visit our Customer Support PortalOpens in a new window for more details. If you booked a property offering free cancellation or took up our reserve now, pay later offer then you may not be out of pocket either.  


Why should I book my adults only resort in Florida Keys with Travelocity?


With Travelocity, you get a fantastic selection of Florida Keys adults only hotel and resort deals in just one click. You can save even more when you bundle your flights and car rental together, too. So, escape for an unforgettable adults-only vacation and book your dream hotel today.


Recent Florida Keys hotel reviews by fellow wanderers