Cheap Flights to Santa Cruz from $275

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How Much Does it Cost To Fly To Santa Cruz?

The cheapest prices found with in the last 7 days for return flights were $409 and $275 for one-way flights to Santa Cruz for the period specified. Prices and availability are subject to change. Additional terms apply

Sun, Feb 21 - Sat, Feb 27
MIA
Miami Intl.
VVI
Viru Viru Intl.
$567 Roundtrip, found 3 hours ago
$567
Roundtrip
found 3 hours ago
Select LATAM Airlines Group flight, departing Sun, Feb 21 from Miami Intl. to Viru Viru Intl., returning Sat, Feb 27, priced at $567 found 3 hours ago
OriginDestinationTravel DatesFlights From*
SCLSanta CruzOctober 28 to November 10$409
SCLSanta CruzOctober 28 to November 10$409
MIASanta CruzDecember 4 to December 11$588
MIASanta CruzDecember 4 to December 11$588
PTYSanta CruzNovember 17 to November 20$662
PTYSanta CruzNovember 17 to November 20$662
MEXSanta CruzDecember 4 to December 13$707
IADSanta CruzNovember 15 to December 6$728
IADSanta CruzNovember 15 to December 6$728
LAXSanta CruzNovember 4 to November 21$791
IAHSanta CruzOctober 21 to October 28$901
MADSanta CruzJanuary 16 to March 3$943
MADSanta CruzJanuary 16 to March 3$943
FCOSanta CruzNovember 13 to December 8$1,095
FCOSanta CruzNovember 13 to December 8$1,095
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
MIASanta CruzOctober 18 to October 24$654
MIASanta CruzOctober 18 to October 24$654
SCLSanta CruzOctober 16 to October 17$672
SCLSanta CruzOctober 16 to October 17$672
BWISanta CruzOctober 17 to December 4$688
BWISanta CruzOctober 17 to December 4$688
MEXSanta CruzOctober 17 to October 21$738
MEXSanta CruzOctober 17 to October 21$738
IADSanta CruzOctober 16 to October 18$774
IADSanta CruzOctober 16 to October 18$774
MADSanta CruzOctober 18 to October 23$1,211
MADSanta CruzOctober 18 to October 23$1,211
IAHSanta CruzOctober 18 to October 25$2,862
IAHSanta CruzOctober 18 to October 25$2,862
*Prices include taxes and fees

Santa Cruz Flight Information

Traveling to
Santa Cruz
Lowest Price
$409
Number of Airlines Serving
Airlines Serving
Boliviana De Aviacion, LATAM Airlines Group
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Amazing Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$135 nightly
The price is $135 total per night from Nov 7 to Nov 8
$135 total
Nov 7 - Nov 8
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol Santa Cruz
$53 nightly
The price is $53 total per night from Oct 31 to Nov 1
$53 total
Oct 31 - Nov 1
Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...
Opens in a new windowHotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
7/10 Good! (76 reviews)
"My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom"

Reviewed on Aug 3, 2025

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Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290 Santa Cruz
$46 nightly
The price is $46 total per night from Nov 10 to Nov 11
$46 total
Nov 10 - Nov 11
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
Opens in a new windowHotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz with Airport Shuttles

Casa Vida

Casa Vida

3.5 out of 5
Condominio Club Campestre Santa Cruz Santa
$76 nightly
The price is $76 total per night from Oct 14 to Oct 15
$76 total
Oct 14 - Oct 15
Book a stay at this family-friendly vacation home in Santa Cruz. Enjoy free WiFi, free parking, and private hot tubs.
9/10 Wonderful! (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"

Reviewed on Sep 28, 2017

Opens in a new windowCasa Vida
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
$108 nightly
The price is $108 total per night from Oct 13 to Oct 14
$108 total
Oct 13 - Oct 14
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (409 reviews)
"A super convenient hotel with spacious rooms and nice grounds. Perfect for a layover on long flights Shuttle service great. Loved our balcony overlooking the pool , sitting with a cup of tea listening to the birds and chilling before a long flight home"

Reviewed on Oct 7, 2026

Opens in a new windowSun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$135 nightly
The price is $135 total per night from Nov 7 to Nov 8
$135 total
Nov 7 - Nov 8
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$135 nightly
The price is $135 total per night from Nov 7 to Nov 8
$135 total
Nov 7 - Nov 8
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
$27 nightly
The price is $27 total per night from Oct 16 to Oct 17
$27 total
Oct 16 - Oct 17
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (107 reviews)
"Book at the hotel and they will take you in to different place. Building entrance key doesn't work most of the time. Very hard to take transportation to and to the place. Male attendants were very friendly and helpful. And many more small details."

Reviewed on Oct 6, 2026

Opens in a new windowApart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa
Great for families

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

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Camino Real Hotel
Great for families

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
$149 nightly
The price is $149 total per night from Nov 10 to Nov 11
$149 total
Nov 10 - Nov 11
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
Opens in a new windowCamino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Frequently asked questions

Which airlines fly to Santa Cruz?
10 carriers fly to Santa Cruz, which means you won't be short on choice. Experienced travelers often recommend:

  • BoA
  • Amaszonas
  • Copa Airlines

What airport is best to fly into Santa Cruz?
There's no need to research flight options into different airports when traveling to Santa Cruz. VVI is the city's only airport, and is located 10 mi from the downtown area.
Where to stay in Santa Cruz
Choosing the perfect place to stay is a key ingredient for an unforgettable travel experience. Select from 174 properties in Santa Cruz and start planning the adventure of your dreams!There's no more suitable time to truly spoil yourself than when you're taking a vacation. Lock in a room at the Los Tajibos Hotel And Convention Center and enjoy a taste of the high life during your stay. Traveling with a smaller budget? Don't worry, you won't be left out in the cold. The Casa Internacional Los Aventureros will keep you and your hip-pocket happy.
Places to visit in Santa Cruz
Don't miss the opportunity to explore Plaza 24 de Septiembre, a public square which has helped influence the economic, cultural and social life here. Seeking some more options? You'll enjoy visiting Cine Center to have a break from hectic sightseeing and simply be entertained by a good movie. And that's not all there is. You'll enjoy finding gifts for family and friends, as well as a few well-deserved treats for yourself, at Ventura Mall.
How to get through airport security fast when traveling to Santa Cruz
If you like the idea of spending more time at the airport restaurants and less time wading through security on your way to Santa Cruz, follow these practical tips:

  • Be sure you know the whereabouts of your travel ID and boarding pass. You don't want to hold up the queue when you're asked to hand them over.
  • Bear in mind that belts with metal buckles can set off the body scanner's alarms. If you have one on, you may be instructed to remove it before continuing.
  • Laptops, digital cameras and other electronic devices must be placed in a tub to be X-rayed.
  • Toothpaste, lip balm and other toiletry items in liquid, gel or cream form need to be stored in containers no larger than 3.4 ounces (100 milliliters). They must also fit in a 1-quart (1-liter) clear zip-lock plastic bag.
  • Consider your choice of footwear. Slippers are great because they're a cinch to step out of when you're doing the airport security checks. Try wearing some on your next journey!
  • Some places have stringent biosecurity laws. Consider where you're off to and whether or not it's permissible to fly with fresh fruit.

Plane Tickets To Santa Cruz

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Santa Cruz. Browse through our inventory to explore a wide range of cheap flights to Santa Cruz to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Santa Cruz as you anxiously await to exit the plane and explore what Santa Cruz has to offer. Considering all the amazing local food and culture in Santa Cruz, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Santa Cruz to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Santa Cruz without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Santa Cruz with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Santa Cruz today!

Explore More Ways to Travel with Travelocity

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.