Book Hotels in Center, MO
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Top Center hotels

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.
Center MO
This apartment includes a garden and barbecue grills.
"We had a lovely stay. The property was beautiful."
Reviewed on Jun 29, 2026

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Center MO
This cabin includes a garden and barbecue grills.
"Very clean and friendly place. Everyone makes you feel very welcome. Enjoyed a nice camp fire. And games of corn hole and horseshoes. Very peaceful and relaxing will definitely be returning to stay in the future. The bunkhouse was very clean and spacious."
Reviewed on Jun 15, 2026

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
$110 nightly
The price is $128 total per night from Aug 16 to Aug 17
$128 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The Staff was friendly and helpful."
Reviewed on Jul 20, 2026

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
$235 nightly
The price is $248 total per night from Jul 26 to Jul 27
$248 total
Jul 26 - Jul 27
Total with taxes and fees
An outdoor pool is featured at this apartment, along with barbecue grills.
"Cutest little cabin, decorated so nice! Loved the outdoor patio area! The pool was a bit murky and the location was not woodsy at all. We were trying to relax outside and there was someone mowing and using a chainsaw across the yard. Communication is perfect! If this place had a prettier location ..."
Reviewed on Jul 14, 2026

Best Western On The River
401 North 3rd Street Hannibal MO
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
"Indoor pool is in the middle of the motel. It's a very different arrangement. Interesting place. There is an outdoor pool as well across the street. Down the street in the next block is all the Tom Sawyer and Huck Finn homes to tour. Perfect location."
Reviewed on Jul 21, 2026

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundable
$77 nightly
The price is $89 total per night from Aug 2 to Aug 3
$89 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"The breakfast foods were tasty and hot every day. The hot buffet included home made biscuits and gravy, sausage patties, hash brown potatoes and scrambled eggs. There was also yogurt, 3 choices of dry cereal and you could make waffles. The swimming pool, spa, and exercise room looked nice. The room ..."
Reviewed on Jul 21, 2026

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundable
$88 nightly
The price is $102 total per night from Aug 2 to Aug 3
$102 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
"The room was quiet, clean, and comfortable. They had a good selection at breakfast."
Reviewed on Jul 21, 2026

Baymont by Wyndham Hannibal
4141 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $69 total per night from Jul 26 to Jul 27
$69 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features an indoor pool and a gym. There's fun for all ages with a children's pool and an arcade/game room, and families will appreciate the onsite ...
"It’s so sad that you can’t bring your breakfast back to your room to give your spouse breakfast in bed instead you have you drag everyone out and can’t even enjoy in the peace of your own space especially when we are introverts"
Reviewed on Jul 21, 2026

Motel 6 Hannibal, MO
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $66 total per night from Aug 21 to Aug 22
$66 total
Aug 21 - Aug 22
Total with taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A fireplace in the lobby and a safe ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Quality Inn & Suites Hannibal West
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"The breakfast foods were tasty and hot every day. The hot buffet included home made biscuits and gravy, sausage patties, hash brown potatoes and scrambled eggs. There was also yogurt, 3 choices of dry cereal and you could make waffles. The swimming pool, spa, and exercise room looked nice. The room was comfortable."
A verified traveler stayed at Quality Inn & Suites Hannibal West
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