Book Hotels in Center, MO
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Top Center hotels

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
$189 nightly
The price is $200 total per night from Apr 6 to Apr 7
$200 total
Apr 6 - Apr 7
Total with taxes and fees
An outdoor pool is featured at this apartment, along with barbecue grills.
Very nice and clean! So cozy and was perfect for our weekend at the lake!
Reviewed on Aug 31, 2025

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Center MO
This cabin includes a garden and barbecue grills.
We had a great time. Plenty of space, clean, nice outdoor areas. Would recommend.
Reviewed on Oct 28, 2025

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
$114 nightly
The price is $132 total per night from Apr 26 to Apr 27
$132 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Room was great and breakfast was fantastic
Reviewed on Mar 30, 2026

Cannon Dam Cabins
42526 Cabin Rd Perry MO
$103 nightly
The price is $109 total per night from Apr 6 to Apr 7
$109 total
Apr 6 - Apr 7
Total with taxes and fees
An indoor pool is featured at this cabin, along with free WiFi in public areas and a picnic area. Barbecue grills are provided for your convenience.
Room was spacious and clean. Ample hot water. All appliances worked as expected. I surprised there was absolutely NO kitchen supplies like coffee filters, salt/pepper, etc. Skillet was worthless. They also need a sign that states the gas station is the check-in site. Good stay overall. Would stay ...
Reviewed on Dec 25, 2025

Best Western On The River
401 North 3rd Street Hannibal MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $116 total per night from Apr 12 to Apr 13
$116 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
Everything was adequate - our rooms air conditioning was not working and it was an 85 degree day- Tony moved us to another room with working air conditioner - much appreciated. The mark Twain diner across the street was a great place for dinner
Reviewed on Apr 1, 2026

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Apr 19 to Apr 20
$89 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Hotel is clean and comfortable. Breakfast is standard fare. We didn’t use any of the amenities. It works for an overnight stay.
Reviewed on Apr 4, 2026

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundable
$88 nightly
The price is $101 total per night from Apr 12 to Apr 13
$101 total
Apr 12 - Apr 13
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Beds comfortable- nice breakfast choices. A pleasant peaceful setting
Reviewed on Mar 30, 2026

Baymont by Wyndham Hannibal
4141 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $73 total per night from Apr 6 to Apr 7
$73 total
Apr 6 - Apr 7
Total with taxes and fees
This hotel features an indoor pool and a gym. There's fun for all ages with a children's pool and an arcade/game room, and families will appreciate the onsite ...
Our room wasn’t even clean there was crumbs on the bed when we walked into our room at 1030 at night after checking in . The toilet paper wasn’t even changed bedding was stained so you could tell the room wasn’t even cleaned when we go back I will never stay here again I’m so disappointed and I love ...
Reviewed on Mar 30, 2026

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.
Center MO
$286 nightly
The price is $302 total per night from Apr 6 to Apr 7
$302 total
Apr 6 - Apr 7
Total with taxes and fees
This apartment features barbecue grills.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Quality Inn & Suites Hannibal West
4 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Hotel is clean and comfortable. Breakfast is standard fare. We didn’t use any of the amenities. It works for an overnight stay. "
A verified traveler stayed at Quality Inn & Suites Hannibal West
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