Book Hotels in Center, MO

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Top Center hotels

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.

Spacious 3-bedroom on a 140 acres minutes from mark twain lake.

Center MO
This apartment includes a garden and barbecue grills.
"We had a lovely stay. The property was beautiful."

Reviewed on Jun 29, 2026

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Opens in a new windowSpacious 3-bedroom on a 140 acres minutes from mark twain lake.
WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE

Center MO
This cabin includes a garden and barbecue grills.
"Very clean and friendly place. Everyone makes you feel very welcome. Enjoyed a nice camp fire. And games of corn hole and horseshoes. Very peaceful and relaxing will definitely be returning to stay in the future. The bunkhouse was very clean and spacious."

Reviewed on Jun 15, 2026

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Opens in a new windowWELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 out of 5
105 Lakeside Dr Hannibal MO
Fully refundable
$110 nightly
The price is $128 total per night from Aug 16 to Aug 17
$128 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The Staff was friendly and helpful."

Reviewed on Jul 20, 2026

Opens in a new windowSleep Inn & Suites Hannibal West
MTL HUNTING LAYAWAY & OUTDOOR HANGOUT

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT

Center MO
$235 nightly
The price is $248 total per night from Jul 26 to Jul 27
$248 total
Jul 26 - Jul 27
Total with taxes and fees
An outdoor pool is featured at this apartment, along with barbecue grills.
"Cutest little cabin, decorated so nice! Loved the outdoor patio area! The pool was a bit murky and the location was not woodsy at all. We were trying to relax outside and there was someone mowing and using a chainsaw across the yard. Communication is perfect! If this place had a prettier location ..."

Reviewed on Jul 14, 2026

Opens in a new windowMTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Best Western On The River

Best Western On The River

2.5 out of 5
401 North 3rd Street Hannibal MO
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
"Indoor pool is in the middle of the motel. It's a very different arrangement. Interesting place. There is an outdoor pool as well across the street. Down the street in the next block is all the Tom Sawyer and Huck Finn homes to tour. Perfect location."

Reviewed on Jul 21, 2026

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Opens in a new windowBest Western On The River
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

2.5 out of 5
120 Lindsey Drive Hannibal MO
Fully refundable
$77 nightly
The price is $89 total per night from Aug 2 to Aug 3
$89 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"The breakfast foods were tasty and hot every day. The hot buffet included home made biscuits and gravy, sausage patties, hash brown potatoes and scrambled eggs. There was also yogurt, 3 choices of dry cereal and you could make waffles. The swimming pool, spa, and exercise room looked nice. The room ..."

Reviewed on Jul 21, 2026

Opens in a new windowQuality Inn & Suites Hannibal West
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
Fully refundable
$88 nightly
The price is $102 total per night from Aug 2 to Aug 3
$102 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
"The room was quiet, clean, and comfortable. They had a good selection at breakfast."

Reviewed on Jul 21, 2026

Opens in a new windowComfort Inn & Suites - Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $69 total per night from Jul 26 to Jul 27
$69 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features an indoor pool and a gym. There's fun for all ages with a children's pool and an arcade/game room, and families will appreciate the onsite ...
"It’s so sad that you can’t bring your breakfast back to your room to give your spouse breakfast in bed instead you have you drag everyone out and can’t even enjoy in the peace of your own space especially when we are introverts"

Reviewed on Jul 21, 2026

Opens in a new windowBaymont by Wyndham Hannibal
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2 out of 5
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $66 total per night from Aug 21 to Aug 22
$66 total
Aug 21 - Aug 22
Total with taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A fireplace in the lobby and a safe ...
Opens in a new windowMotel 6 Hannibal, MO
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Center?
From well-designed amenities to larger rooms, kid-friendly hotels come with features that can help turn a great family vacation into a fabulous one. These Center options make vacationing with children a piece of cake: WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE will help make your next trip the best one yet. It offers a host of nice little touches, such as a water park and animal viewing activities. Also check out the deals at Mark Twain lake getaway at Blue Lagoon!. It offers a firepit, pet-friendly facilities and ample opportunities for family time.
Where can I find cheap hotels in Center?
At Travelocity you'll find really nice hotels in Center at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Center rather than in Center. We may find you even better rates, too.
How do I find the best Center hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Center then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Center?
The cheapest hotel in Center is $66. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Center?
There are 117 hotels in Center on Travelocity.
What are the best hotels in Center?
Center has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Center for you!
When is the best time to visit Center?
If you want the joy of a fun-filled trip in peak season, visit Center during May, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Center?
Based on historic data is usually the cheapest month to visit Center. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Center?
There are multiple hotels in Center that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Center. We have plenty of kid-friendly hotels in Center to choose from on Travelocity!
Why book a hotel in Center through Travelocity?
Because we have the top hotels in Center! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Center on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Center hotel reviews by fellow wanderers

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"The breakfast foods were tasty and hot every day. The hot buffet included home made biscuits and gravy, sausage patties, hash brown potatoes and scrambled eggs. There was also yogurt, 3 choices of dry cereal and you could make waffles. The swimming pool, spa, and exercise room looked nice. The room was comfortable."
A verified traveler stayed at Quality Inn & Suites Hannibal West
Quality Inn & Suites Hannibal West

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