Book Hotels in Center, MO
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Top Center hotels

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
The price is $189 total per night from Feb 22 to Feb 23
$189 total
per night
Feb 22 - Feb 23
An outdoor pool is featured at this apartment, along with barbecue grills.
Very nice and clean! So cozy and was perfect for our weekend at the lake!
Reviewed on Aug 31, 2025

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
The price is $117 total per night from Mar 22 to Mar 23
$117 total
per night
Mar 22 - Mar 23
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
It was a good midway stop for us on our way to Memphis.
Reviewed on Feb 11, 2026

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Center MO
This cabin includes a garden and barbecue grills.
We had a great time. Plenty of space, clean, nice outdoor areas. Would recommend.
Reviewed on Oct 28, 2025

Cannon Dam Cabins
42526 Cabin Rd Perry MO
The price is $109 total per night from Feb 20 to Feb 21
$109 total
per night
Feb 20 - Feb 21
An indoor pool is featured at this cabin, along with free WiFi in public areas and a picnic area. Barbecue grills are provided for your convenience.
Room was spacious and clean. Ample hot water. All appliances worked as expected. I surprised there was absolutely NO kitchen supplies like coffee filters, salt/pepper, etc. Skillet was worthless. They also need a sign that states the gas station is the check-in site. Good stay overall. Would stay ...
Reviewed on Dec 25, 2025

Best Western On The River
401 North 3rd Street Hannibal MO
Fully refundableReserve now, pay when you stay
The price is $81 total per night from Feb 20 to Feb 21
$81 total
per night
Feb 20 - Feb 21
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
Room was perfect for a nightly get away after spending way too long in the hospital. It was very peaceful, relaxing and helpful. Would definitely recommend.
Reviewed on Feb 11, 2026

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundableReserve now, pay when you stay
The price is $81 total per night from Feb 26 to Feb 27
$81 total
per night
Feb 26 - Feb 27
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Nice stay
Reviewed on Feb 17, 2026

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
The price is $86 total per night from Feb 28 to Mar 1
$86 total
per night
Feb 28 - Mar 1
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Everything was clean and staff was friendly. Just needed some updates.
Reviewed on Feb 5, 2026

Motel 6 Hannibal, MO
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
The price is $63 total per night from Mar 3 to Mar 4
$63 total
per night
Mar 3 - Mar 4
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A snack bar/deli and a fireplace in ...
The room was spotless and fresh. Assistance was cheerfully offered when needed.
Reviewed on Jan 25, 2026

Spacious 3-bedroom on a 140 acre working farm minutes from mark twain lake.
Center MO
The price is $286 total per night from Feb 22 to Feb 23
$286 total
per night
Feb 22 - Feb 23
This apartment features barbecue grills.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Quality Inn & Suites Hannibal West
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Nice stay"
A verified traveler stayed at Quality Inn & Suites Hannibal West
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