Book Hotels in Center, MO

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Center hotels

Sleep Inn & Suites

Sleep Inn & Suites

2.5 out of 5
105 Lakeside Dr, Hannibal, MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $127 total per night from Aug 24 to Aug 25
$127 total
Aug 24 - Aug 25
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The tub is slick. You need mats or strips!! The noisy plastic comforter is weird and noisy."

Reviewed on Jul 21, 2025

Sleep Inn & Suites
WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE

Center
This cabin features a water park, a garden, and barbecue grills.
"Very good for family/friends groups. Would book a stay again!"

Reviewed on Jun 18, 2025

Get rates
WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Best Western On The River

Best Western On The River

2.5 out of 5
401 North 3rd Street, Hannibal, MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Jul 27 to Jul 28
$146 total
Jul 27 - Jul 28
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
"Room was nice and clean. Was not told my room was not ready, found out when I went to the room. However, housekeeping staff were understanding and cleaned it right away once I told them I had to be somewhere within the hour."

Reviewed on Jul 24, 2025

Best Western On The River
FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City

2 out of 5
3 Gateway Square Drive, Monroe City, MO
$74 nightly
The price is $81 total per night from Aug 7 to Aug 8
$81 total
Aug 7 - Aug 8
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Laundry facilities are provided for your ...
"Nice hotel. Rooms had great A/C. Very easy to check in."

Reviewed on Jul 11, 2025

FairBridge Inn Express, Monroe City
Quality Inn & Suites Hannibal

Quality Inn & Suites Hannibal

2.5 out of 5
120 Lindsey Drive, Hannibal, MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $119 total per night from Aug 3 to Aug 4
$119 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features a bar/lounge, a poolside bar, and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Good location, very welcoming, room was comfortable & breakfast was tasty."

Reviewed on Jul 20, 2025

Quality Inn & Suites Hannibal
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St, Hannibal, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $118 total per night from Jul 27 to Jul 28
$118 total
Jul 27 - Jul 28
Total includes taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Great area and clean facilities"

Reviewed on Jul 21, 2025

Comfort Inn & Suites - Hannibal
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2 out of 5
123 Huckleberry Heights Dr, Hannibal, MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $63 total per night from Jul 27 to Jul 28
$63 total
Jul 27 - Jul 28
Total includes taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A snack bar/deli and a fireplace in ...
"Good night for a good price"

Reviewed on Jul 14, 2025

Motel 6 Hannibal, MO
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2 out of 5
120 Huckleberry Heights Dr, Hannibal, MO
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $73 total per night from Jul 29 to Jul 30
$73 total
Jul 29 - Jul 30
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. If you want to take your pet along, this pet-friendly ...
"The staff was wonderful and everything was neat and clean. The beds were comfortable and the service provided was great. The only change I would make would be to have a few more choices for breakfast. Fresh fruit and yogurt would be appreciated"

Reviewed on Jul 23, 2025

Super 8 by Wyndham Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St, Hannibal, MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $79 total per night from Jul 27 to Jul 28
$79 total
Jul 27 - Jul 28
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Nice place, they're remodeling but no big deal, room was clean, bed was comfortable and the pool area was nice"

Reviewed on Jul 23, 2025

Baymont by Wyndham Hannibal
Don't see what you're looking for?
See all available properties in Center
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Center?
From well-designed amenities to larger rooms, kid-friendly hotels come with features that can help turn a great family vacation into a fabulous one. These Center options make vacationing with children a piece of cake: WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE will help make your next trip the best one yet. It offers a host of nice little touches, such as a water park and animal viewing activities. Also check out the deals at Mark Twain lake getaway at Blue Lagoon!. It offers a firepit, pet-friendly facilities and ample opportunities for family time.
Where can I find cheap hotels in Center?
At Travelocity you'll find really nice hotels in Center at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Center rather than in Center. We may find you even better rates, too.
How do I find the best Center hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Center then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Center?
The cheapest hotel in Center is $63. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Center?
There are 112 hotels in Center on Travelocity.
What are the best hotels in Center?
Center has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Center for you!
When is the best time to visit Center?
If you want the joy of a fun-filled trip in peak season, visit Center during May, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Center?
Based on historic data is usually the cheapest month to visit Center. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Center?
There are multiple hotels in Center that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Center. We have plenty of kid-friendly hotels in Center to choose from on Travelocity!
Why book a hotel in Center through Travelocity?
Because we have the top hotels in Center! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Center on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Center hotel reviews by fellow wanderers

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Great area and clean facilities"
A verified traveler stayed at Comfort Inn & Suites - Hannibal
Comfort Inn & Suites - Hannibal
Explore More Ways to Travel with Travelocity

Explore More Ways to Travel with Travelocity