Book Hotels in Center, MO
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Top Center hotels

MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
Center MO
$187 nightly
The price is $198 total per night from Jan 5 to Jan 6
$198 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
A water park and an outdoor pool are featured at this smoke-free apartment. Families will appreciate the playground and barbecue grills.
Very nice and clean! So cozy and was perfect for our weekend at the lake!
Reviewed on Aug 31, 2025

Sleep Inn & Suites Hannibal West
105 Lakeside Dr Hannibal MO
Fully refundable
$101 nightly
The price is $117 total per night from Jan 3 to Jan 4
$117 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Walking in greeted with a pleasant smile, helpful, my questions answered. Good customer service is very rare nowadays. I appreciate it. Everything was very clean, no odors from pets, people smoking outside.
Reviewed on Dec 9, 2025

WELCOME TO WESTHOFF CAMPGROUND BUNKHOUSE
Center MO
This cabin features a water park, a garden, and barbecue grills.
We had a great time. Plenty of space, clean, nice outdoor areas. Would recommend.
Reviewed on Oct 28, 2025

Best Western On The River
401 North 3rd Street Hannibal MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $116 total per night from Dec 16 to Dec 17
$116 total
Dec 16 - Dec 17
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal ...
Great stay! Clean and cozy!!
Reviewed on Dec 8, 2025

Quality Inn & Suites Hannibal West
120 Lindsey Drive Hannibal MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $92 total per night from Jan 2 to Jan 3
$92 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Very nice place to stay during a snow storm.
Reviewed on Dec 1, 2025

Comfort Inn & Suites - Hannibal
4000 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $96 total per night from Dec 21 to Dec 22
$96 total
Dec 21 - Dec 22
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Nice staff, comfortable bed, good breakfast. Not enough towels in the room, broken microwave.
Reviewed on Nov 29, 2025

Motel 6 Hannibal, MO
123 Huckleberry Heights Dr Hannibal MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $67 total per night from Jan 1 to Jan 2
$67 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A snack bar/deli and a fireplace in ...
very nice owner and staff
Reviewed on Nov 25, 2025

Days Inn by Wyndham Hannibal
4070 Market St Hannibal MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Dec 27 to Dec 28
$72 total
Dec 27 - Dec 28
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free continental breakfast each morning. A garden, express ...
Great
Reviewed on Nov 28, 2025

Spacious 3-bedroom on a 140 acre working farm minutes from mark twain lake.
Center MO
$279 nightly
The price is $279 total per night from Dec 15 to Dec 16
$279 total
Dec 15 - Dec 16
Total with taxes and fees
This apartment features a water park and barbecue grills.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Center hotel reviews by fellow wanderers

Sleep Inn & Suites Hannibal West
5 out of 5
Posted 5 days ago
Travelocity Verified Review
" Walking in greeted with a pleasant smile, helpful, my questions answered. Good customer service is very rare nowadays. I appreciate it.
Everything was very clean, no odors from pets, people smoking outside.
"
A verified traveler stayed at Sleep Inn & Suites Hannibal West
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