Explore top 2026 5 Star Hotels in Andean Natural Region

Name: Ecolodge Palonegro
Price range: $126 total

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Top Andean Natural Region 5 Star hotels

The Click Clack Hotel Medellin

Calle 10B # 37-29 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$201 nightly

$201 total

Jul 13 - Jul 14

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and airport shuttle. ...

9.2/10 Wonderful! (1,158 reviews)

"Amazing"

Reviewed on Jul 5, 2026

NH Collection Medellín Royal

Carrera 42 No 5 Sur 130 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$121 nightly

$121 total

Jul 10 - Jul 11

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (1,004 reviews)

"Todo fue excelente la comida deliciosa y la atención excelente"

Reviewed on Jul 5, 2026

The Charlee Hotel

Calle 9a 37 16 Medellín

Fully refundableReserve now, pay when you stay

$231 nightly

$231 total

Jul 15 - Jul 16

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free ...

8.8/10 Excellent! (1,004 reviews)

"The property was in a good location, even though there is a lot of noise at night, their rooms are pretty sound proof. It’s a good area, but if traveling with family, there are lots of prostitutes around the area. So not sure. The hotel amenities are good. The breakfast is à la carte during the weekdays ..."

Reviewed on Jul 5, 2026

Binn Hotel

Carrera 25 No. 10-51 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$256 nightly

$256 total

Jul 7 - Jul 8

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (1,004 reviews)

"Very friendly, amazing staff. Great breakfasts. Great value. Willbe back!"

Reviewed on Jul 6, 2026

Medellin Marriott Hotel

Calle 1a Sur #43a-83 Medellín

Fully refundableReserve now, pay when you stay

$294 nightly

$294 total

Jul 17 - Jul 18

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (615 reviews)

"The stay here was outstanding! I would highly endorse anyone's stay here."

Reviewed on Jul 5, 2026

York Medellin, Curio Collection by Hilton

Carrera 43a 17sur 63 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$161 nightly

$161 total

Jul 14 - Jul 15

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

9.6/10 Exceptional! (1,145 reviews)

"Wonderful staff in the restaurant and front desk!"

Reviewed on Jul 5, 2026

Devú

# 9-32 Carrera 32d Medellín Antioquia

Fully refundableReserve now, pay when you stay

$268 nightly

$268 total

Jul 7 - Jul 8

This aparthotel features free WiFi in public areas, dry cleaning, and laundry facilities. Multilingual staff can provide around-the-clock assistance and concierge ...

9.8/10 Exceptional! (15 reviews)

"I stayed at Devú Hotel for nine nights, and it exceeded my expectations. My room was beautifully designed, quiet, and incredibly comfortable. The service throughout my stay was exceptional. A special thank you to Mateo, the manager, who went above and beyond to make me feel welcome. He and the entire ..."

Reviewed on Jun 30, 2026

Luxury Suites Prana By Cadissa

Calle 35 # 63B-36 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$122 nightly

$122 total

Jul 7 - Jul 8

This apartment's 2 hot tubs and gym are among the featured amenities. Business travelers can take advantage of the free WiFi in public areas. Enjoy the steam ...

9.4/10 Exceptional! (47 reviews)

"Checking in after hours was a little difficult if you don’t speak Spanish, using the robot at front desk. Definitely needed more towels in apartment and more pots for cooking"

Reviewed on Jun 15, 2026

Bosko

46,5 km From José María Córdoba Airport Guatapé Antioquia

Fully refundableReserve now, pay when you stay

$297 nightly

$297 total

Jul 7 - Jul 8

Ski-in/ski-out access, a full-service spa, and 2 outdoor pools are all featured at this smoke-free lodge. Traveling on business? Take advantage of the free WiFi ...

9.6/10 Exceptional! (211 reviews)

"Awesome views. Food excellent."

Reviewed on Jul 2, 2026

Ecolodge Palonegro

KILOMETRO 1 VIA AEROPUERTO PALONEGRO Lebrija Santander

$126 nightly

$126 total

Aug 6 - Aug 7

This lodge features free self parking and free WiFi in public areas. Enjoy the 3 hot tubs and free full breakfast each morning. A garden, a lobby fireplace, ...

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Andean Natural Region Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Andean Natural Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Andean Natural Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Andean Natural Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Andean Natural Region hotel reviews by fellow wanderers

V Grand Hotel, a member of Radisson Individuals

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"The hotel is clean and the staff is excellent! They are very friendly and helpful. Always there to help and assist. I had a really good experience! I will come back for sure!"

A verified traveler stayed at V Grand Hotel, a member of Radisson Individuals