Explore top 2026 5 Star Hotels in Andean Natural Region

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Top Andean Natural Region 5 Star hotels

The Click Clack Hotel Medellin

Calle 10B # 37-29 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$197 nightly

$197 total

Jun 16 - Jun 17

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and airport shuttle. ...

9.2/10 Wonderful! (1,132 reviews)

"GREAT IN ALL .............REAL 5 STARS!!!"

Reviewed on May 15, 2026

NH Collection Medellín Royal

Carrera 42 No 5 Sur 130 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$109 nightly

$109 total

Jun 14 - Jun 15

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (1,000 reviews)

"Everything was satisfactory until the morning of checkout. My wife went for a run in the morning, and the bellboy ran after her to ask if she was going to check out, as if she intended to steal from the premises. This occurred at 9:30am, although check-out was not until 12 p.m. After we completed ..."

Reviewed on May 18, 2026

The Charlee Hotel

Calle 9a 37 16 Medellín

Fully refundableReserve now, pay when you stay

$208 nightly

$208 total

Jun 1 - Jun 2

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free ...

8.8/10 Excellent! (1,006 reviews)

"Jessica went above and beyond very appreciative of her service and kindness, highly recommend and will be back just to do the Experience and help she provided us. Thank you"

Reviewed on May 16, 2026

Binn Hotel

Carrera 25 No. 10-51 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$182 nightly

$182 total

Jun 18 - Jun 19

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (1,001 reviews)

"Very nice place, 24 hour room service, in-house restaurants, 24 hour gym, very well located. Will definitely be back again."

Reviewed on May 16, 2026

Medellin Marriott Hotel

Calle 1a Sur #43a-83 Medellín

Fully refundableReserve now, pay when you stay

$294 nightly

$294 total

Jun 19 - Jun 20

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (608 reviews)

"Nice bed nice location God food"

Reviewed on May 6, 2026

Devú

# 9-32 Carrera 32d Medellín Antioquia

Fully refundableReserve now, pay when you stay

$272 nightly

$272 total

May 24 - May 25

This aparthotel features free WiFi in public areas, dry cleaning, and laundry facilities. Multilingual staff can provide around-the-clock assistance and concierge ...

10/10 Exceptional! (5 reviews)

"Our week-long stay at Hotel Devú was an overall fantastic experience, highlighted by an incredibly warm and professional welcome that set the tone for the entire trip. The rooms were consistently spotless and well-maintained, and the customer service across the board was a perfect 5 out of 5. The ..."

Reviewed on May 12, 2026

Luxury Suites Prana By Cadissa

Calle 35 # 63B-36 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$113 nightly

$113 total

May 24 - May 25

This apartment's 2 hot tubs and gym are among the featured amenities. Business travelers can take advantage of the free WiFi in public areas. Enjoy the steam ...

9.4/10 Exceptional! (43 reviews)

"My only complaint was that the hot water was very wishy washy, other than that, perfect"

Reviewed on May 15, 2026

Ecolodge Palonegro

KILOMETRO 1 VIA AEROPUERTO PALONEGRO Lebrija Santander

$122 nightly

$122 total

Jun 3 - Jun 4

This lodge features free self parking and free WiFi in public areas. Enjoy the 3 hot tubs and free full breakfast each morning. A garden, a lobby fireplace, ...

HOBBIT HOTEL

Vereda el Marial El Peñol Antioquia

$103 nightly

$103 total

May 21 - May 22

A rooftop terrace, free self parking, and laundry facilities are featured at this lodge. WiFi in public areas is free. A picnic area and barbecue grills are ...

10/10 Exceptional! (2 reviews)

"Had a wonderful stay with Monica and Jairo in their lovely space. The beds were super comfortable, the pillows heavenly, and the towels fluffy. My hosts were very hospitable and made my stay as pleasant as possible. They were eager to help, open feedback, and proactive in terms of resolving issues. ..."

Reviewed on Jul 21, 2023

30 Living Suites

82C-40 Cl. 30 Medellín Antioquia

This apartment doesn't skimp on freebies - guests receive free full breakfast and free WiFi. Traveling on business? Take advantage of the business center, conference ...

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Andean Natural Region Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Andean Natural Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Andean Natural Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Andean Natural Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.