Explore top 2026 5 Star Hotels in Andean Natural Region

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Andean Natural Region 5 Star hotels

NH Collection Medellín Royal

Carrera 42 No 5 Sur 130 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$109 nightly

$109 total

May 1 - May 2

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (1,005 reviews)

Breakfast was excellent room was clean and nice

Reviewed on Apr 3, 2026

The Click Clack Hotel Medellin

Calle 10B # 37-29 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$192 nightly

$192 total

Apr 6 - Apr 7

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and airport shuttle. ...

9.2/10 Wonderful! (1,125 reviews)

I think this was not for us the breakfast was great and varied but the hotel tries hard to be trendy when for us it would be great to have a good nice sleep and be able to hang your clothes . We got awaken twice during the night when the TV came on for no reason apparently due to a fault in the area ...

Reviewed on Apr 2, 2026

The Charlee Hotel

Calle 9a 37 16 Medellín

Fully refundableReserve now, pay when you stay

$167 nightly

$167 total

Apr 5 - Apr 6

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free ...

8.8/10 Excellent! (1,000 reviews)

Reviewed on Mar 25, 2026

Binn Hotel

Carrera 25 No. 10-51 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$188 nightly

$188 total

May 4 - May 5

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (1,003 reviews)

Nos encanto el hotel,el desayuno espectacular,la atencion exelente en especial por parte del señor Adolfo en el restaurant me senti en casa,gracias por la atencion especial

Reviewed on Apr 2, 2026

Medellin Marriott Hotel

Calle 1a Sur #43a-83 Medellín

Fully refundableReserve now, pay when you stay

$329 nightly

$329 total

Apr 4 - Apr 5

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (601 reviews)

Service was superb, friendly, so eager to please.

Reviewed on Mar 23, 2026

Luxury Suites Prana By Cadissa

Calle 35 # 63B-36 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$127 nightly

$127 total

Apr 7 - Apr 8

This apartment's 2 hot tubs and gym are among the featured amenities. Business travelers can take advantage of the free WiFi in public areas. Enjoy the steam ...

9.2/10 Wonderful! (39 reviews)

This is an amazing property. The hosts are exceptional, and the bot is friendly and useful when the host are not available.

Reviewed on Mar 23, 2026

Ecolodge Palonegro

KILOMETRO 1 VIA AEROPUERTO PALONEGRO Lebrija Santander

$131 nightly

$131 total

Apr 4 - Apr 5

This lodge features free self parking and free WiFi in public areas. Enjoy the 3 hot tubs and free full breakfast each morning. A garden, a lobby fireplace, ...

HOBBIT HOTEL

Vereda el Marial El Peñol Antioquia

$106 nightly

$106 total

Apr 12 - Apr 13

A rooftop terrace, free self parking, and laundry facilities are featured at this lodge. WiFi in public areas is free. A picnic area and barbecue grills are ...

10/10 Exceptional! (2 reviews)

Had a wonderful stay with Monica and Jairo in their lovely space. The beds were super comfortable, the pillows heavenly, and the towels fluffy. My hosts were very hospitable and made my stay as pleasant as possible. They were eager to help, open feedback, and proactive in terms of resolving issues. ...

Reviewed on Jul 21, 2023

30 Living Suites

82C-40 Cl. 30 Medellín Antioquia

This apartment doesn't skimp on freebies - guests receive free full breakfast and free WiFi. Traveling on business? Take advantage of the business center, conference ...

Get rates

Morph by MOME Stays

Calle 1 #35 - 70 Medellín Antioquia

This apartment features an outdoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Free self parking, a garden, and a ...

Get rates

Don't see what you're looking for?

See all available properties in Andean Natural Region

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Andean Natural Region Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Andean Natural Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Andean Natural Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Andean Natural Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.