American Airlines Flight AA4645 Deals & Information (2025/2026)

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American Airlines Flight 4645 Route Deals From $214

The cheapest prices found with in the last 7 days for return flights were $189 and $214 for one-way flights to Ronald Reagan Washington National for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 17 - Sat, Oct 18
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 17 from Columbia Metropolitan to Ronald Reagan Washington National, returning Sat, Oct 18, priced at $189 found 1 day ago
Mon, Oct 6 - Tue, Oct 14
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$193 Roundtrip, found 5 hours ago
$193
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Mon, Oct 6 from Columbia Metropolitan to Ronald Reagan Washington National, returning Tue, Oct 14, priced at $193 found 5 hours ago
Sat, Oct 4 - Sun, Oct 5
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$193 Roundtrip, found 3 days ago
$193
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Oct 4 from Columbia Metropolitan to Ronald Reagan Washington National, returning Sun, Oct 5, priced at $193 found 3 days ago
Fri, Sep 19 - Mon, Sep 22
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$203 Roundtrip, found 4 days ago
$203
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Sep 19 from Columbia Metropolitan to Ronald Reagan Washington National, returning Mon, Sep 22, priced at $203 found 4 days ago
Fri, Jan 16 - Mon, Jan 19
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$219 Roundtrip, found 1 day ago
$219
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 16 from Columbia Metropolitan to Ronald Reagan Washington National, returning Mon, Jan 19, priced at $219 found 1 day ago
Mon, Oct 6 - Tue, Oct 14
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$223 Roundtrip, found 5 hours ago
$223
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Mon, Oct 6 from Columbia Metropolitan to Ronald Reagan Washington National, returning Tue, Oct 14, priced at $223 found 5 hours ago
Fri, Oct 17 - Sat, Oct 18
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$227 Roundtrip, found 1 day ago
$227
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 17 from Columbia Metropolitan to Ronald Reagan Washington National, returning Sat, Oct 18, priced at $227 found 1 day ago
Fri, Sep 19 - Mon, Sep 22
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$229 Roundtrip, found 4 days ago
$229
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Sep 19 from Columbia Metropolitan to Ronald Reagan Washington National, returning Mon, Sep 22, priced at $229 found 4 days ago
Fri, Oct 17 - Sat, Oct 18
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$229 Roundtrip, found 1 day ago
$229
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 17 from Columbia Metropolitan to Ronald Reagan Washington National, returning Sat, Oct 18, priced at $229 found 1 day ago
Mon, Oct 6 - Tue, Oct 14
CAE
Columbia Metropolitan
DCA
Ronald Reagan Washington National
$231 Roundtrip, found 5 hours ago
$231
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Mon, Oct 6 from Columbia Metropolitan to Ronald Reagan Washington National, returning Tue, Oct 14, priced at $231 found 5 hours ago

Frequently asked questions

What route does flight number AA4645 take?
You'll be landing at Key West Intl. Airport from New York, NY Airport (LGA-LaGuardia) if you've booked a ticket on flight number AA4645. You'll be airborne for 3 hours and 20 minutes during this trip. It's also good to note that it conveniently travels non-stop.
What terminal does AA4645 fly out of?
Flight number AA4645 runs between LGA and EYW, and those booked on this flight normally board the aircraft from Terminal B.
What kind of plane is on flight number AA4645?
The route for AA4645 is usually LGA to Key West Intl. Airport, and the Embraer 175 is the type of plane you'll probably be taking off on.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4645 flight with Travelocity, please visit our Customer Service Portal.