American Airlines Flight 4645 Deals & Information (2026/2027)

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American Airlines Flight 4645 Route Deals From $157

The cheapest prices found with in the last 7 days for return flights were $275 and $157 for one-way flights to O'Hare Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 3 - Sat, Jul 11
SYR
Hancock Intl.
ORD
O'Hare Intl.
$275 Roundtrip, found 18 hours ago
$275
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Fri, Jul 3 from Hancock Intl. to O'Hare Intl., returning Sat, Jul 11, priced at $275 found 18 hours ago
Thu, Jul 23 - Sun, Jul 26
SYR
Hancock Intl.
ORD
O'Hare Intl.
$279 Roundtrip, found 1 day ago
$279
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jul 23 from Hancock Intl. to O'Hare Intl., returning Sun, Jul 26, priced at $279 found 1 day ago
Fri, Jul 10 - Mon, Jul 13
SYR
Hancock Intl.
ORD
O'Hare Intl.
$286 Roundtrip, found 4 hours ago
$286
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jul 10 from Hancock Intl. to O'Hare Intl., returning Mon, Jul 13, priced at $286 found 4 hours ago
Fri, Jul 10 - Mon, Jul 13
SYR
Hancock Intl.
ORD
O'Hare Intl.
$296 Roundtrip, found 4 hours ago
$296
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jul 10 from Hancock Intl. to O'Hare Intl., returning Mon, Jul 13, priced at $296 found 4 hours ago
Fri, Jun 19 - Tue, Jun 23
SYR
Hancock Intl.
ORD
O'Hare Intl.
$297 Roundtrip, found 1 day ago
$297
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jun 19 from Hancock Intl. to O'Hare Intl., returning Tue, Jun 23, priced at $297 found 1 day ago
Thu, Jul 23 - Sun, Jul 26
SYR
Hancock Intl.
ORD
O'Hare Intl.
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jul 23 from Hancock Intl. to O'Hare Intl., returning Sun, Jul 26, priced at $299 found 1 day ago
Fri, Jul 10 - Mon, Jul 13
SYR
Hancock Intl.
ORD
O'Hare Intl.
$306 Roundtrip, found 4 hours ago
$306
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jul 10 from Hancock Intl. to O'Hare Intl., returning Mon, Jul 13, priced at $306 found 4 hours ago
Thu, May 28 - Sun, May 31
SYR
Hancock Intl.
ORD
O'Hare Intl.
$308 Roundtrip, found 6 days ago
$308
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, May 28 from Hancock Intl. to O'Hare Intl., returning Sun, May 31, priced at $308 found 6 days ago
Fri, Sep 18 - Sat, Sep 19
SYR
Hancock Intl.
ORD
O'Hare Intl.
$308 Roundtrip, found 2 days ago
$308
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Sep 18 from Hancock Intl. to O'Hare Intl., returning Sat, Sep 19, priced at $308 found 2 days ago
Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$309 Roundtrip, found 3 days ago
$309
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $309 found 3 days ago

Frequently asked questions

What route does flight number AA4645 take?
You'll be landing at Key West Intl. Airport from New York, NY Airport (LGA-LaGuardia) if you've booked a ticket on flight number AA4645. You'll be airborne for 3 hours and 20 minutes during this trip. It's also good to note that it conveniently travels non-stop.
What terminal does AA4645 fly out of?
Flight number AA4645 runs between LGA and EYW, and those booked on this flight normally board the aircraft from Terminal B.
What kind of plane is on flight number AA4645?
The route for AA4645 is usually LGA to Key West Intl. Airport, and the Embraer 175 is the type of plane you'll probably be taking off on.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4645 flight with Travelocity, please visit our Customer Service Portal.