American Airlines Flight 4645 Deals & Information (2026/2027)

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American Airlines Flight 4645 Route Deals From $157

The cheapest prices found with in the last 7 days for return flights were $269 and $157 for one-way flights to O'Hare Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$269 Roundtrip, found 15 hours ago
$269
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $269 found 15 hours ago
Fri, Jul 10 - Mon, Jul 13
SYR
Hancock Intl.
ORD
O'Hare Intl.
$275 Roundtrip, found 3 hours ago
$275
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Jul 10 from Hancock Intl. to O'Hare Intl., returning Mon, Jul 13, priced at $275 found 3 hours ago
Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$279 Roundtrip, found 15 hours ago
$279
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $279 found 15 hours ago
Fri, Jul 10 - Mon, Jul 13
SYR
Hancock Intl.
ORD
O'Hare Intl.
$286 Roundtrip, found 3 hours ago
$286
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Jul 10 from Hancock Intl. to O'Hare Intl., returning Mon, Jul 13, priced at $286 found 3 hours ago
Thu, Aug 13 - Mon, Aug 17
SYR
Hancock Intl.
ORD
O'Hare Intl.
$289 Roundtrip, found 4 days ago
$289
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Aug 13 from Hancock Intl. to O'Hare Intl., returning Mon, Aug 17, priced at $289 found 4 days ago
Sat, Oct 24 - Tue, Oct 27
SYR
Hancock Intl.
ORD
O'Hare Intl.
$294 Roundtrip, found 4 days ago
$294
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 24 from Hancock Intl. to O'Hare Intl., returning Tue, Oct 27, priced at $294 found 4 days ago
Thu, Jul 23 - Sun, Jul 26
SYR
Hancock Intl.
ORD
O'Hare Intl.
$299 Roundtrip, found 4 hours ago
$299
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Thu, Jul 23 from Hancock Intl. to O'Hare Intl., returning Sun, Jul 26, priced at $299 found 4 hours ago
Wed, Jul 15 - Sat, Jul 18
SYR
Hancock Intl.
ORD
O'Hare Intl.
$301 Roundtrip, found 5 days ago
$301
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jul 15 from Hancock Intl. to O'Hare Intl., returning Sat, Jul 18, priced at $301 found 5 days ago
Sat, Oct 24 - Tue, Oct 27
SYR
Hancock Intl.
ORD
O'Hare Intl.
$304 Roundtrip, found 4 days ago
$304
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 24 from Hancock Intl. to O'Hare Intl., returning Tue, Oct 27, priced at $304 found 4 days ago
Thu, May 28 - Sun, May 31
SYR
Hancock Intl.
ORD
O'Hare Intl.
$308 Roundtrip, found 4 days ago
$308
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, May 28 from Hancock Intl. to O'Hare Intl., returning Sun, May 31, priced at $308 found 4 days ago

Frequently asked questions

What route does flight number AA4645 take?
You'll be landing at Key West Intl. Airport from New York, NY Airport (LGA-LaGuardia) if you've booked a ticket on flight number AA4645. You'll be airborne for 3 hours and 20 minutes during this trip. It's also good to note that it conveniently travels non-stop.
What terminal does AA4645 fly out of?
Flight number AA4645 runs between LGA and EYW, and those booked on this flight normally board the aircraft from Terminal B.
What kind of plane is on flight number AA4645?
The route for AA4645 is usually LGA to Key West Intl. Airport, and the Embraer 175 is the type of plane you'll probably be taking off on.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4645 flight with Travelocity, please visit our Customer Service Portal.