Deals on vacations and trips to San Francisco

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San Francisco flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was $1,292, price is now $892 per person
$892
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
This smoke-free resort features a casino, 2 indoor tennis courts, and a restaurant. Bring the family and enjoy the children's pool, playground, and kid-friendly dining. Enjoy the outdoor pool and free perks like full breakfast and valet parking.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,496, price is now $1,223 per person
$1,223
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,811, price is now $988 per person
$988
per person
Dec 17 - Dec 21
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.
Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

3.5 out of 5
Casco Viejo
Save 100% on your flight
Price was $1,669, price is now $1,152 per person
$1,152
per person
Dec 17 - Dec 22
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
Free WiFi in public areas is available at this apartment. Take advantage of the self parking.
Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3.5 out of 5
Casco Viejo
Price was $1,351, price is now $972 per person
$972
per person
Dec 17 - Dec 22
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
This apartment features a virtual front desk.

Top San Francisco hotels deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Free Cancellation
Reserve now, pay when you stay
$139 nightly
The price is $139 total per night
$139 total
Oct 12 - Oct 13
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.
Pool
Hot Tub
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
$106 nightly
The price is $117 total per night
$117 total
Sep 30 - Oct 1
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy the free buffet breakfast each morning.
Pool
Breakfast included
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Free Cancellation
Reserve now, pay when you stay
$101 nightly
The price is $111 total per night
$111 total
Oct 12 - Oct 13
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and free valet parking. Enjoy the outdoor pool and free buffet breakfast each morning.
Pool
Breakfast included
Aloft by Marriott Panama

Aloft by Marriott Panama

3.5 out of 5
Via Israel & Calle 76 Panama City Panama
Free Cancellation
Reserve now, pay when you stay
$132 nightly
The price is $146 total per night
$146 total
Oct 9 - Oct 10
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the outdoor pool and perks like free self parking.
Pool
Pet friendly
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Free Cancellation
Reserve now, pay when you stay
$122 nightly
The price is $135 total per night
$135 total
Oct 25 - Oct 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.
Pool
Pet friendly
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Free Cancellation
Reserve now, pay when you stay
$151 nightly
The price is $166 total per night
$166 total
Oct 30 - Oct 31
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.
Pool
Spa
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular San Francisco attractions

Multiplaza Pacific Mall

9.0/10 (4,497 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
See properties

Frequently asked questions

How much are vacation packages to San Francisco?
$892 is all you need to spend for an unforgettable escape in San Francisco. Bundle your hotel and flights into a Travelocity package and watch all the savings pile up. With these kinds of prices, there's never been a better time to travel.
Where can I get the best vacation package deals for San Francisco?
It's hard to look past Travelocity when it comes to piecing together your San Francisco package deal. There are as many as 400 partner airlines and 1,000,000 worldwide properties to choose from. Reserve your trip now and get ready to cross another amazing place off your must-visit list.
Why should I book my San Francisco vacation bundle via Travelocity?
From our 24/7 customer care to our range of incredible destinations, we're dedicated to fulfilling your travel desires. All you need to do is click and book — our Price Match Guarantee will ensure you lock in the best deal.
Can I save on my San Francisco car rental if I combine it with a hotel or flight?
Sure can — and booking one of our San Francisco vacation packages is the best way to go about this. Bundle any combination of a car, hotel, flight and experience and score serious discounts. The more you book, the more you'll save. There are so many famous sights in San Francisco to put on your bucket list, including Gatun Locks (35 mi from San Francisco). Nothing tops exploring places like this with the freedom of your own wheels.
What is there to do in San Francisco?
Multicentro Panama and Panama Canal Murals are loved by tourists and locals alike. Tick these places off your San Francisco itinerary and see what the hype is about.

Photos of local treasures

Browse San Francisco vacation photos for more inspiration

A bridge over a body of water with several boats.
A beach with a large driftwood piece, calm water, and a few people in the distance.
A city skyline with a flag, a river, and a park.
A cityscape with a distinctive twisted skyscraper, a busy highway, and surrounding modern buildings.
A cityscape with a rainbow over buildings.