San Francisco Vacation Packages 2025 from $529

San Francisco flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Villa F&B

per person

Aug 2 - Aug 6

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

This hotel features a restaurant and 3 beach bars. Business travelers can take advantage of the free WiFi in public areas. Enjoy the outdoor pool and free full breakfast each morning.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

per person

Jul 13 - Jul 19

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Punta Caracol Acqua Lodge

Punta Caracol

Save 100% on your flight

per person

Jul 10 - Jul 15

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this lodge. WiFi in public areas is free. A coffee shop, a terrace, and a garden are also on offer.

Discovery Gunayar

per person

Aug 22 - Aug 29

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

Hotel Panamonte

per person

Aug 28 - Sep 2

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this hotel. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate the area shuttle, terrace, and garden.

Top San Francisco hotels deals

JW Marriott Panama

Calle Punta Colon, Punta Pacifica, Panama City, Panama

Free Cancellation

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This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and valet parking. There's a poolside bar on site, and concierge services and wedding services are also provided.

Pool

Spa

Megapolis Hotel Panamá

Avenida Balboa, Panama City

Free Cancellation

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This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Ramada Plaza By Wyndham Panama Punta Pacífica

Via Israel y Calle 71, San Francisco, Panama City, Panama

Free Cancellation

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This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy the free buffet breakfast each morning.

Pool

Breakfast included

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Paitilla, Panama City, Panama

Free Cancellation

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A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. You'll appreciate the gym, bar/lounge, and coffee shop.

Pool

Spa

Decapolis Hotel Panama City

Avenida Balboa Con Multicentro, Panama City, Panama

Free Cancellation

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This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and free valet parking. Enjoy the outdoor pool and free buffet breakfast each morning.

Pool

Breakfast included

Sheraton Grand Panama

Via Israel And 77th Street, Panama City, Panama

Free Cancellation

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A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly dining, and in-room childcare. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like free self parking and WiFi in public areas.

Pool

Spa

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

4.5/5(634 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

ATLAPA Conventions Center

3.5/5(21 reviews)

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its lively bars.

Multicentro Panama

4/5(148 reviews)

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Frequently asked questions

How much are vacation packages to San Francisco?

$529 is all you need to spend for an unforgettable escape in San Francisco. Bundle your hotel and flights into a Travelocity package and watch all the savings pile up. With these kinds of prices, there’s never been a better time to travel.

Where can I get the best vacation package deals for San Francisco?

It’s hard to look past Travelocity when it comes to piecing together your San Francisco package deal. There are as many as 400 partner airlines and 1,000,000 worldwide properties to choose from. Reserve your trip now and get ready to cross another amazing place off your must-visit list.

Why should I book my San Francisco vacation bundle via Travelocity?

From our 24/7 customer care to our range of incredible destinations, we’re dedicated to fulfilling your travel desires. All you need to do is click and book — our Price Match Guarantee will ensure you lock in the best deal.

Can I save on my San Francisco car rental if I combine it with a hotel or flight?

Sure can — and booking one of our San Francisco vacation packages is the best way to go about this. Bundle any combination of a car, hotel, flight and experience and score serious discounts. The more you book, the more you’ll save. There are so many famous sights in San Francisco to put on your bucket list, including Gatun Locks (35 mi from San Francisco). Nothing tops exploring places like this with the freedom of your own wheels.

What is there to do in San Francisco?

Multicentro Panama and Panama Canal Murals are loved by tourists and locals alike. Tick these places off your San Francisco itinerary and see what the hype is about.