Hotels on the Lake in Upstate South Carolina

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Top Upstate South Carolina Hotels on the Lake

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Get rates
This vacation home features a garden, laundry facilities, and barbecue grills. There's fun for all ages with a playground and an arcade/game room.
Relax on the shore of Lake Hartwell in our Fair Play retreat

Relax on the shore of Lake Hartwell in our Fair Play retreat

Get rates
A water park and a hot tub are featured at this smoke-free vacation home. A garden, a computer station, and laundry facilities are also on offer.
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

3 out of 5
240 Madren Center Drive, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
A golf course, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center ...
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Get rates
A gym is featured at this cabin, along with a garden and laundry facilities. Barbecue grills are provided for your convenience.
Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area

2.5 out of 5
851 Tiger Blvd, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business ...
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson

3.5 out of 5
1387 Tiger Blvd, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Studio 6 Greenville, SC - I-85 Near Downtown

Studio 6 Greenville, SC - I-85 Near Downtown

2 out of 5
12 Impact Dr, Greenville, SC
Free Cancellation
Reserve now, pay when you stay
Get rates
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Laundry facilities and barbecue grills are also provided.
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Upstate South Carolina hotels essential information

Accommodation
2,697 hotels
Lowest Price
Highest Price
Popular hotels
Relax on the shore of Lake Hartwell in our Fair Play retreat, 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks, Clemson University's James F. Martin Inn, Hampton Inn & Suites Seneca-Clemson Area, Best Western Seneca-Clemson, Days Inn by Wyndham Seneca / Clemson Area, Fall fun at the cabin! Convenient to Lake Keowee and Clemson, Hampton Inn Clemson-University Area, Days Inn by Wyndham Clemson, Studio 6 Greenville, SC - I-85 Near Downtown

Recent Upstate South Carolina hotel reviews by fellow wanderers

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

5 out of 5
Posted 22 hours ago
Travelocity Verified Review
"Very nice and clean everyone was real nice"
A verified traveler stayed at Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG