Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$219 nightly
The price is $241 total per night from Jun 21 to Jun 22
$241 total
Jun 21 - Jun 22
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"The hotel is very well kept and a great place to stay for couples to get away and relax."
Reviewed on Jun 14, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $273 total per night from Jul 5 to Jul 6
$273 total
Jul 5 - Jul 6
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"The Grand Bohemian is a beautiful hotel in a prime location. It’s within easy walking distance of Falls Park, Main Street, and the Peace Center, and the overall atmosphere is serene and relaxing. The rooms are clean and spacious, the bed was very comfortable, the bath products were excellent, and ..."
Reviewed on Jun 14, 2026
Drury Inn & Suites Greenville
10 Carolina Point Pkwy Greenville SC
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Jun 21 to Jun 22
$131 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"From the time we checked in to the time we checked out, everything was great. The amenities were great. The room was clean. The staff was super friendly. We had no idea about the complimentary meal that was served on Friday and Saturday, along with three complimentary drinks. Would definitely stay ..."
Reviewed on Jun 14, 2026
Hyatt Place Greenville Downtown
128 East Broad Street Greenville SC
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $158 total per night from Jun 21 to Jun 22
$158 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Very nice place. Room was clean and beds were comfortable. Staff was friendly but didn't know a lot about the city. Mini frig leaked water. But over all very nice place to stay close to walk to a lot of things to see."
Reviewed on Jun 15, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Jun 28 to Jun 29
$121 total
Jun 28 - Jun 29
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The room was extremely clean. Just outdated furniture"
Reviewed on Jun 14, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $172 total per night from Jul 1 to Jul 2
$172 total
Jul 1 - Jul 2
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The hotel is in need of some renovations, but overall it offers decent value for the price, especially compared to other options in town. Sunday breakfast is buffet-style. There are no specialty coffee options available on-site, so you’ll need to visit a nearby coffee shop if that’s important to ..."
Reviewed on Jun 14, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$101 nightly
The price is $111 total per night from Jun 29 to Jun 30
$111 total
Jun 29 - Jun 30
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Good"
Reviewed on Jun 13, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Jun 29 to Jun 30
$121 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Great time. Staff was friendly and the place was very clean"
Reviewed on Jun 14, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $98 total per night from Jun 29 to Jun 30
$98 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Great place to stay. It is prohibited to smoke or vape which is great but, they allow pets. We found doggy waste in the hallway on the 6th floor and it smelled horrible."
Reviewed on Jun 13, 2026
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd Anderson SC
$64 nightly
The price is $71 total per night from Jul 12 to Jul 13
$71 total
Jul 12 - Jul 13
Total with taxes and fees
7/10 Good! (889 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
32 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Best Western Plus Clemson Hotel & Conference Center
4 out of 5
Posted 6 hours ago
Travelocity Verified Review
"Moons were clean spacious stuff was excellent breakfast was great and all it was one of my more favorable experiences staying in a hotel"
A verified traveler stayed at Best Western Plus Clemson Hotel & Conference Center
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