Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Free WiFi in public areas is available at this cottage.
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Opens in a new windowWooded Cottage - 3 Mi to Clemson University
Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Dec 19 to Dec 20
$135 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
The first day, we had no hot water. It was a major inconvenience since I could not shower before work and cold water shave was very painful. But they made good on their promise credit that night back. I do think they could’ve been more timely and getting the boiler repaired since it went down in ...

Reviewed on Dec 9, 2025

Opens in a new windowHomewood Suites by Hilton Greenville Downtown
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$295 nightly
The price is $324 total per night from Jan 4 to Jan 5
$324 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Gorgeous, clean, unique, so special!!

Reviewed on Dec 8, 2025

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $88 total per night from Dec 21 to Dec 22
$88 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
yes

Reviewed on Dec 5, 2025

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Dec 21 to Dec 22
$101 total
Dec 21 - Dec 22
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
I had to recheck the price I was paying just to make sure I wasn’t paying more than I thought I was. Stay was excellent. Was clean, felt upscale, comfortable, and good breakfast.

Reviewed on Dec 5, 2025

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
$87 nightly
The price is $96 total per night from Dec 14 to Dec 15
$96 total
Dec 14 - Dec 15
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Staff was great, awesome customer service!

Reviewed on Dec 8, 2025

Opens in a new windowCrowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

3 out of 5
11 Ketron Court Greenville SC
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $94 total per night from Dec 15 to Dec 16
$94 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and ...
Yes

Reviewed on Dec 3, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Dec 14 to Dec 15
$110 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Can use a little updating but overall good location.

Reviewed on Dec 5, 2025

Opens in a new windowHilton Greenville
ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

2 out of 5
490 W Blackstock Road Spartanburg SC
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $81 total per night from Dec 14 to Dec 15
$81 total
Dec 14 - Dec 15
Total with taxes and fees
A 24-hour gym, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide ...
I was impressed upon entrance to the lobby! Everything was clean in neat and the receptionist was AWESOME!

Reviewed on Dec 8, 2025

Opens in a new windowECHO Suites Extended Stay by Wyndham Spartanburg
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

128 Interstate Blvd Anderson SC
$64 nightly
The price is $71 total per night from Dec 16 to Dec 17
$71 total
Dec 16 - Dec 17
Total with taxes and fees
7/10 Good! (842 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"The first day, we had no hot water. It was a major inconvenience since I could not shower before work and cold water shave was very painful. But they made good on their promise credit that night back. I do think they could’ve been more timely and getting the boiler repaired since it went down in the late evening of the day that I checked in and the service man didn’t come until mid morning the next day."
A verified traveler stayed at Homewood Suites by Hilton Greenville Downtown
Homewood Suites by Hilton Greenville Downtown

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