Book Hotels in Upstate South Carolina, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top hotels

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Breakfast and coffee was fantastic"

Reviewed on Jun 19, 2025

Best Western Plus Greenville I-385 Inn & Suites
Courtyard by Marriott Greenville Haywood Mall

Courtyard by Marriott Greenville Haywood Mall

3 out of 5
70 Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"Need better pillows. The beds are very comfortable"

Reviewed on Jun 21, 2025

Courtyard by Marriott Greenville Haywood Mall
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Very nice, great location!"

Reviewed on Jun 18, 2025

Hyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Just going to say this is the place that we will always stay at when visiting South Carolina"

Reviewed on Jun 10, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport

2.5 out of 5
205 Entertainment Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
Free WiFi in public areas is provided and the front desk is staffed around-the-clock. Free self parking and luggage storage are also offered on site.
"The hotel is was amazing I’ll book it again"

Reviewed on Jun 22, 2025

Woodspring Suites Greenville Airport
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Great location - not sure why a suburban hotel charges $10 a night for parking -"

Reviewed on Jun 21, 2025

Hilton Greenville
Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

2.5 out of 5
246 Congaree Road, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Great place to live"

Reviewed on Jun 19, 2025

Comfort Inn Greenville - Haywood Mall
Quality Inn & Suites Greenville - Haywood Mall

Quality Inn & Suites Greenville - Haywood Mall

2.5 out of 5
50 Orchard Park Drive, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self ...
"My stay was rather good. Didn't have any issues with the check in, staff, and the room. I felt like I got what I paid for and will stay here gain when in the area"

Reviewed on Jun 15, 2025

Quality Inn & Suites Greenville - Haywood Mall
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

3 out of 5
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...
"Property need some updating but stay was good overall"

Reviewed on Jun 20, 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity

Explore More Ways to Travel with Travelocity