Eastern Panama Vacation Packages 2025/2026 from $719

Eastern Panama flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$719

per person

Nov 8 - Nov 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Central Hotel Bocas del Toro

Save 100% on your flight

$1,120

per person

Dec 18 - Dec 21

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Panama City (PTY)

A marina and a restaurant are featured at this hotel. Enjoy the outdoor pool and free perks like continental breakfast and WiFi in public areas. A bar/lounge, a 24-hour front desk, and dry cleaning are also provided.

Villa Botero By Casa Mojito B&B

Save 100% on your flight

$807

per person

Dec 6 - Dec 13

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Panama City (PTY)

This bed & breakfast features an outdoor pool and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. An area shuttle, a casino shuttle, and laundry facilities are also offered.

Isla Palenque Member of the Cayuga Collection

Save 100% on your flight

$2,741

per person

Dec 18 - Dec 21

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Panama City (PTY)

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free lodge. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. A terrace, a garden, and a snack bar/deli are also on offer.

Bambuda Bocas Town - Hostel

$975

per person

Dec 6 - Dec 13

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this hostel. A terrace, a communal living room, and dry cleaning are also on offer.

Top Eastern Panama hotels deals

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

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A full-service spa, 3 restaurants, and 4 outdoor pools are all featured at this smoke-free hotel. Relax with a drink at the beach bar and enjoy free perks like cooked-to-order breakfast and valet parking. A business center, free WiFi in public areas, and a terrace are also on offer.

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island, Narganá, Guna Yala

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This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Hotel Cocotal

La Guaira, Isla Grande, Provincia de Colón

Free Cancellation

Reserve now, pay when you stay

$83 nightly

$92 total

Oct 5 - Oct 6

Total with taxes and fees

This smoke-free hotel features 20 restaurants and 20 bars/lounges. Enjoy a meal in one of the 19 coffee shops/cafes and free perks like cooked-to-order breakfast and WiFi in public areas. Wedding services are provided for your convenience.

Breakfast included

Pet friendly

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

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Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

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This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like full breakfast and free self parking.

On private beach

Pool

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

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This villa features limo/town car service, a garden, and laundry facilities. Barbecue grills are provided for your convenience.

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Secluded island in the Guna Yala region of Panama

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as $719. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.