Book Hotels in Eastern Panama

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Eastern Panama hotels

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
$420 nightly
The price is $464 total per night from Oct 7 to Oct 8
$464 total
Oct 7 - Oct 8
Total with taxes and fees
This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax ...
"La comida estaba deliciosa, el staff con excelente atención. La playa privada es un super plus."

Reviewed on Jul 19, 2026

Opens in a new windowOrdovician Beach Resort
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Sep 8 to Sep 9
$207 total
Sep 8 - Sep 9
Total with taxes and fees
This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Opens in a new windowPrivate Ocean-Front Cabin with private bathroom on San Blas Island
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
$121 nightly
The price is $134 total per night from Oct 1 to Oct 2
$134 total
Oct 1 - Oct 2
Total with taxes and fees
A restaurant and an outdoor pool are featured at this hotel. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free ...
"Here's a natural, conversational review in English: We had a wonderful stay here. The hotel is beautiful, with an amazing pool overlooking both the ocean and the rainforest. Everything was very clean, and the beds were extremely comfortable. The staff were incredibly friendly and welcoming. The owner ..."

Reviewed on Jun 2, 2026

Opens in a new windowRanchos de Chalia
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale Cacique Provincia de Colón
$207 nightly
The price is $228 total per night from Sep 8 to Sep 9
$228 total
Sep 8 - Sep 9
Total with taxes and fees
A full-service spa, 3 restaurants, and 4 outdoor pools are all featured at this smoke-free hotel. Relax with a drink at the beach bar and enjoy free perks like ...
"Everything was awesome, the howler monkeys, the staff the lot"

Reviewed on Sep 5, 2026

Opens in a new windowCiel y Miel
Discovery Gunayar

Discovery Gunayar

2 out of 5
Archipiélago de San Blas Narganá Guna Yala
$117 nightly
The price is $129 total per night from Oct 7 to Oct 8
$129 total
Oct 7 - Oct 8
Total with taxes and fees
Stay at this lodge in Narganá. Enjoy free breakfast, an airport shuttle (surcharge), and housekeeping. Popular attractions Isla Chichime and Isla Diablo are ...
"Please fix my Expedia mobile app. It hasn’t worked for several days. The error message says the problem is at Expedia’s end. I have reported this issue by phone but nothing is being done."

Reviewed on Jan 13, 2025

Opens in a new windowDiscovery Gunayar
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
$99 nightly
The price is $109 total per night from Sep 25 to Sep 26
$109 total
Sep 25 - Sep 26
Total with taxes and fees
This hotel features a restaurant, a bar/lounge, and a beach bar. If you want to take your pet along, this pet-friendly property offers everything you'll need ...
"Rundown hotel. Not worth the price"

Reviewed on Aug 31, 2026

Opens in a new windowHOTEL ISLA GRANDE
san blas luxury tour

san blas luxury tour

2 out of 5
guna yala Nusatupo Guna Yala
$119 nightly
The price is $131 total per night from Sep 7 to Sep 8
$131 total
Sep 7 - Sep 8
Total with taxes and fees
This cabin doesn't skimp on freebies - guests receive free full breakfast and a free beach shuttle. Relax with beach cabanas and beach umbrellas, and cool off ...
Opens in a new windowsan blas luxury tour
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,698 nightly
The price is $1,902 total per night from Oct 7 to Oct 8
$1,902 total
Oct 7 - Oct 8
Total with taxes and fees
A restaurant and a bar/lounge are featured at this cruise ship. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee ...
Opens in a new windowCocoloco - Catamaran Lagoon 52F SAN BLAS
San Blas Private Beach Cabin

San Blas Private Beach Cabin

2.5 out of 5
Nusatupo Narganá Guna Yala
$268 nightly
The price is $295 total per night from Sep 8 to Sep 9
$295 total
Sep 8 - Sep 9
Total with taxes and fees
This cabin features a restaurant, an area shuttle, and a terrace. Enjoy the free continental breakfast each morning. Barbecue grills are provided for your ...
Opens in a new windowSan Blas Private Beach Cabin
Don't see what you're looking for?
See all available properties in Eastern Panama
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Eastern Panama hotel reviews by fellow wanderers