Explore top 2025 4 Star Hotels in Eastern Panama

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Top Eastern Panama 4 Star hotels

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax ...

10/10 Exceptional! (3 reviews)

"Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special."

Reviewed on Sep 5, 2025

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Mandalas Ecolodge

Via a Cerro Azul, Caimitillo, Panamá Province

This lodge features an outdoor pool and a rooftop terrace. Free self parking and a garden are also offered on site.

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El Otro Lado

Bahia de Portobelo, Portobelo, Colon

This lodge features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, ...

"Amazing"

Reviewed on Feb 7, 2020

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Portobello Historico

Calle Guenea Via Principal Portobelo, Al lado del Puente del Rey, Portobelo

This apartment doesn't skimp on freebies - guests receive free WiFi and free self parking. A terrace is also provided.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Eastern Panama

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Eastern Panama 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Eastern Panama will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Eastern Panama, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.