Eastern Panama Vacation Packages 2025 from $790

Eastern Panama flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Villa Marina Lodge & Condos

per person

Aug 1 - Aug 6

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

This inn features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy perks like free self parking and free WiFi. A terrace, a garden, and a snack bar/deli are also on offer.

Residencia Natural

Save 100% on your flight

per person

Jul 31 - Aug 3

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Panama City (PTY)

This aparthotel features a restaurant, an area shuttle, and free self parking. Guests will appreciate perks like free WiFi and a free airport shuttle. A terrace, a garden, and a snack bar/deli are also on offer.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

per person

Aug 27 - Sep 2

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Hotel Panamonte

per person

Jul 20 - Jul 27

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this hotel. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate the area shuttle, terrace, and garden.

Villa Botero By Casa Mojito B&B

per person

Aug 23 - Aug 30

found 1 day ago

Roundtrip non-stop flight included

Philadelphia (PHL) to Panama City (PTY)

This bed & breakfast features an outdoor pool and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. An area shuttle, a casino shuttle, and laundry facilities are also offered.

Top Eastern Panama hotels deals

Private Over the Water Cabin on San Blas Island

9.542876, -78.899058, Narganá, San Blas

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This cabin features a restaurant, a coffee shop, and a terrace. Enjoy the free local cuisine breakfast each morning. A garden and a snack bar/deli are also provided.

Breakfast included

Kitchen

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

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Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

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A restaurant and an outdoor pool are featured at this hotel. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A garden and a virtual front desk are also provided.

Pool

Breakfast included

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

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This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like full breakfast and free self parking.

On private beach

Pool

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

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A full-service spa, 3 restaurants, and 4 outdoor pools are all featured at this smoke-free hotel. Relax with a drink at the beach bar and enjoy free perks like cooked-to-order breakfast and valet parking. A business center, free WiFi in public areas, and a terrace are also on offer.

Pool

Breakfast included

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir, Narganá, Guna Yala

Free Cancellation

Reserve now, pay when you stay

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A restaurant and a bar/lounge are featured at this property. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.

Breakfast included

Free WiFi

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Secluded island in the Guna Yala region of Panama

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as $790. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life’s a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You’ll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.