Book a hotel near Fort Defiance State Park, Cairo
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Top hotels close to Fort Defiance State Park

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St Charleston MO
Free Cancellation
Reserve now, pay when you stay
10.88 mi from Fort Defiance State Park
$62 nightly
The price is $69 total per night
$69 total
Mar 14 - Mar 15
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.
Breakfast included
Pet friendly

The Riverstone Hotel Charleston-Sikeston
102 Drake St Charleston MO
Free Cancellation
Reserve now, pay when you stay
12.55 mi from Fort Defiance State Park
$70 nightly
The price is $78 total per night
$78 total
Mar 14 - Mar 15
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business center and free internet in public areas. A safe deposit box is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly

Peaceful secluded cabin located near Horseshoe Lake
Miller City IL
13.12 mi from Fort Defiance State Park
$174 nightly
The price is $184 total per night
$184 total
Mar 15 - Mar 16
Total with taxes and fees
This cabin features barbecue grills.
Kitchen
Pet friendly

Cozy cabins on beautiful Horseshoe Lake
Olive Branch IL
17.13 mi from Fort Defiance State Park
$133 nightly
The price is $140 total per night
$140 total
Mar 15 - Mar 16
Total with taxes and fees
Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Air conditioning
Lake view

The Rested Duck Mallard Room
Olive Branch IL
17.13 mi from Fort Defiance State Park
$133 nightly
The price is $140 total per night
$140 total
Mar 14 - Mar 15
Total with taxes and fees
Stay at this cabin in Alexander County. Enjoy air conditioning.
Air conditioning

Ducks and geese are here! Booking for turkey season too. We're ready for you!
Tamms IL
19.46 mi from Fort Defiance State Park
This vacation home features a garden, laundry facilities, and barbecue grills.
Kitchen
Washer

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Kevil KY
20.85 mi from Fort Defiance State Park
$137 nightly
The price is $155 total per night
$155 total
Mar 14 - Mar 15
Total with taxes and fees
This vacation home featured laundry facilities and barbecue grills.
Kitchen
Washer

Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
22.32 mi from Fort Defiance State Park
$82 nightly
The price is $93 total per night
$93 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.
Pool
Breakfast included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
22.34 mi from Fort Defiance State Park
$68 nightly
The price is $78 total per night
$78 total
Mar 16 - Mar 17
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
22.55 mi from Fort Defiance State Park
$94 nightly
The price is $108 total per night
$108 total
Mar 18 - Mar 19
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
100 Matthews Lane Sikeston MO
Free Cancellation
Reserve now, pay when you stay
22.61 mi from Fort Defiance State Park
$60 nightly
The price is $69 total per night
$69 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.
Breakfast included
Pet friendly

Drury Inn & Suites Paducah
2930 James Sanders Blvd Paducah KY
Free Cancellation
Reserve now, pay when you stay
26.29 mi from Fort Defiance State Park
$106 nightly
The price is $125 total per night
$125 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Fort Defiance State Park
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Fort Defiance State Park hotels essential information
Accommodation | 196 hotels |
|---|---|
Lowest Price | $69 |
Highest Price | $184 |
Popular hotels | Super 8 by Wyndham Charleston/Sikeston East MO, The Riverstone Hotel Charleston-Sikeston, Peaceful secluded cabin located near Horseshoe Lake , Cozy cabins on beautiful Horseshoe Lake, The Rested Duck Mallard Room, Drury Inn & Suites Sikeston, MO, Ducks and geese are here! Booking for turkey season too. We're ready for you!, Best Western Plus Sikeston I-55, Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer., Days Inn and Suites by Wyndham Sikeston, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67), Drury Inn & Suites Paducah |
Recent Fort Defiance State Park hotel reviews by fellow wanderers

Drury Inn & Suites Paducah
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Our room was great and the staff was super nice! We love these hotels in Texas so naturally wanted to stay in one while we were traveling. "
A verified traveler stayed at Drury Inn & Suites Paducah





