
Cheap Flights to O'Higgins Region from $144 (2025/2026)
Wander Wisely with exceptional service, 24/7 supportOpens in a new window
Feel at ease with free flight cancellations within 24 hours of booking
Change your flight without a fee on select flights
Jet to one of O'Higgins Region's top cities

Santa Cruz
Flights
How Much Does it Cost To Fly To O'Higgins Region?
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
MIA
Miami Intl.
SCL
Arturo Merino Benitez
$345 Roundtrip, found 3 days ago
$345
Roundtrip
found 3 days ago
SJO
Juan Santamaría Intl.
SCL
Arturo Merino Benitez
$361 Roundtrip, found 4 hours ago
$361
Roundtrip
found 4 hours ago
PUJ
Punta Cana Intl.
SCL
Arturo Merino Benitez
$379 Roundtrip, found 4 days ago
$379
Roundtrip
found 4 days ago
IAD
Washington Dulles Intl.
SCL
Arturo Merino Benitez
$492 Roundtrip, found 2 hours ago
$492
Roundtrip
found 2 hours ago
SFO
San Francisco Intl.
SCL
Arturo Merino Benitez
$503 Roundtrip, found 3 hours ago
$503
Roundtrip
found 3 hours ago
MSP
Minneapolis - St. Paul Intl.
SCL
Arturo Merino Benitez
$504 Roundtrip, found 16 hours ago
$504
Roundtrip
found 16 hours ago
LAX
Los Angeles Intl.
SCL
Arturo Merino Benitez
$512 Roundtrip, found 16 hours ago
$512
Roundtrip
found 16 hours ago
MCO
Orlando Intl.
SCL
Arturo Merino Benitez
$518 Roundtrip, found 5 days ago
$518
Roundtrip
found 5 days ago
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| EZE | Santiago | January 22 to January 27 | $173 |
| GRU | Santiago | December 1 to December 7 | $207 |
| MIA | Santiago | February 7 to February 9 | $400 |
| YYZ | Santiago | November 23 to November 27 | $486 |
| LAX | Santiago | January 27 to February 8 | $650 |
| JFK | Santiago | February 17 to February 26 | $673 |
| MAD | Santiago | January 22 to January 28 | $674 |
| LGA | Santiago | January 14 to January 25 | $694 |
| CCS | Santiago | November 27 to February 25 | $809 |
| FCO | Santiago | November 24 to December 8 | $812 |
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| EZE | Santiago | November 16 to November 22 | $194 |
| GRU | Santiago | November 16 to November 21 | $259 |
| MIA | Santiago | November 16 to November 22 | $463 |
| YYZ | Santiago | November 16 to December 1 | $560 |
| LAX | Santiago | November 16 to November 18 | $660 |
| JFK | Santiago | November 14 to November 20 | $708 |
| LGA | Santiago | November 14 to November 18 | $733 |
| MAD | Santiago | November 15 to December 9 | $1,402 |
| FCO | Santiago | November 15 to December 12 | $1,509 |
| CCS | Santiago | November 16 to December 6 | $1,546 |
Best O'Higgins Region Flight and Hotel Packages
Price found within the past 48 hours. Click for updated prices.



Don't see what you're looking for?
See all available trips from Houston to O'Higgins Region
View all tripsTravelers ❤️ These O'Higgins Region 🏨

Vik Chile
Valle de Millahue, San Vicente, O'Higgins
Stay at this 5-star luxury hotel in San Vicente. Enjoy free breakfast, free parking, and 2 restaurants. Popular attractions Viña Vik and Bodegas Viña Caliterra are located nearby.
9/10 Wonderful! (150 reviews)
If I could rate this place 11/10 I would. Despite the fact the hotel and surrounding grounds are incredible, the staff and experiences are what make this place. We have never been somewhere with such exceptional service. Would highly recommend the trip out of Santiago to anyone visiting Chile
Reviewed on Oct 5, 2025

Santa Cruz Plaza
Plaza De Armas 286, Santa Cruz, O'Higgins
Stay at this 4-star spa hotel in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Plaza de Armas and Museo de Colchagua are located nearby.
8.6/10 Excellent! (330 reviews)
No table in room, only one chair in room. Not able to sit with my wife to order a drink from the bar since we had no place to sit or place our bar food (no table)
Reviewed on Sep 25, 2025

Diego De Almagro Rancagua
Av.Libertador Bernardo O'Higgins 34, Rancagua, O'Higgins
Stay at this 3-star business-friendly hotel in Rancagua. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Estadio El Teniente and Reserva Nacional Rio Cipreses are located nearby.
8.4/10 Very Good! (134 reviews)
Geat one night stay.
Nice big twin room. Breakfast had loads of fruit and healthy options. Easy parking underneath. Staff friendly. Approx 15 mins walk into town.
Reviewed on Oct 26, 2025
Save an average of 15% on thousands of hotels when you're signed in

Hotel Cava Colchagua
Barreales´s Way, 3km from Santa Cruz Square, Santa Cruz, O'Higgins
Stay at this 4-star spa hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and an attached winery. Popular attractions Laura Hartwig Winery and Casino Colchagua are located nearby.
8.8/10 Excellent! (167 reviews)
Hermosa localidad y buen servicio.
Reviewed on Oct 24, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Ways To Wander O'Higgins Region
O'Higgins Region Hotels
Find the perfect hotel after your flight
O'Higgins Region Vacation Rentals
Great Deals on alternative accommodations
O'Higgins Region Car Rentals
Affordable cars to get you around town
O'Higgins Region Vacations
Save more by combining flights, hotels and cars
Things to do in O'Higgins Region
Activities, attractions and tours
Frequently asked questions
Explore More Ways to Travel with Travelocity
- Cabins in Colchagua Valley Wine Route
- Hotels with Room Service in Colchagua Valley Wine Route
- Hotel Wedding Venues Hotels in Colchagua Valley Wine Route
- Colchagua Valley Wine Route Hotels
- Lodges in Colchagua Valley Wine Route
- Palmilla Hotels
- Rancagua Hotels
- B&B in Lolol
- Topocalma Hotels
- San Vicente Hotels
- Cheap Hotels in Santa Cruz
- Convention Center Hotels in Santa Cruz
- Hotels with Suites in Santa Cruz
- Oceanfront Hotels in Santa Cruz
- Santa Cruz Hotels
- Palaces in Santa Cruz
- Treehouses in Santa Cruz
- Pelequen Hotels
- Boutique Hotels in Pichilemu
- Oceanfront Hotels in Pichilemu
- Chimbarongo Hotels
- La Boca Hotels
- Historic Hotels in San Fernando
- Hotels with Suites in San Fernando
- Hotels with Free Airport Shuttle in San Fernando
- Hotels with Hot Tubs in San Fernando
- Romantic Getaways & Hotels in San Fernando
- Ski Resorts and in San Fernando
- Spa Resorts & in San Fernando
- San Fernando Hotels
- Marchihue Hotels
- Puertecillo Hotels
- Rengo Hotels
- Graneros Hotels
- El Durazno Hotels
- Peumo Hotels
- Mostazal Hotels
- Cáhuil Hotels
- Sewell Hotels
- Machali Hotels
- Navidad Hotels





