Cheap Flights to Santa Cruz from $125

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How Much Does it Cost To Fly To Santa Cruz?

The cheapest prices found with in the last 7 days for return flights were $173 and $125 for one-way flights to Santa Cruz for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel DatesFlights From*
EZESantiagoJanuary 22 to January 27$173
GRUSantiagoDecember 5 to December 7$207
MIASantiagoJanuary 21 to March 2$413
YYZSantiagoNovember 20 to November 26$486
MADSantiagoFebruary 3 to February 25$652
JFKSantiagoFebruary 17 to February 26$673
LAXSantiagoJanuary 13 to January 22$678
LGASantiagoJanuary 29 to February 13$690
FCOSantiagoJanuary 27 to March 4$843
CCSSantiagoDecember 22 to December 31$912
*Prices include taxes and fees
OriginDestinationTravel DatesFlights From*
EZESantiagoNovember 16 to November 22$194
GRUSantiagoNovember 16 to November 18$254
YYZSantiagoNovember 16 to December 1$466
MIASantiagoNovember 16 to December 13$529
LAXSantiagoNovember 14 to November 21$743
JFKSantiagoNovember 15 to November 18$751
LGASantiagoNovember 14 to November 25$788
MADSantiagoNovember 15 to December 9$1,124
CCSSantiagoNovember 16 to December 7$1,397
*Prices include taxes and fees

Santa Cruz Flight Information

Traveling to
Santa Cruz
Lowest Price
$173
Number of Airlines Serving
Airlines Serving
SKY AIRLINE, Arajet, Sky Airline Peru
Number of Daily Flights
Airlines with Direct Flights

Find The Perfect Hotel For After Your Flight

Luxury Hotels in Santa Cruz

TerraViña

TerraViña

3 out of 5
Camino Los Boldos S/n, Santa Cruz, O'Higgins
$162 nightly
The price is $162 total per night from Nov 14 to Nov 15
$162 total
Nov 14 - Nov 15
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza ...
9.2/10 Wonderful! (200 reviews)
Beautiful setting next to a vineyard, with a pool. Restaurant on-site. Well maintained grass. Clean room with nice bedsheets and a good A/C. Good breakfast in a beautiful setting. Very nice views to the vineyard from the room and the restaurant. The explanation given about charging IVA to Chileans ...

Reviewed on Sep 20, 2025

Opens in a new windowTerraViña
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Hotel Boutique Solaz Bella Vista de Colchagua

Hotel Boutique Solaz Bella Vista de Colchagua

3 out of 5
San Pedro de Callihue Lote 5 J, Santa Cruz, O'Higgins
$78 nightly
The price is $78 total per night from Nov 16 to Nov 17
$78 total
Nov 16 - Nov 17
Stay at this 3-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza de Armas are ...
9.2/10 Wonderful! (96 reviews)
Really recommended. Breakfast is very good, staff is amazing. A jewel close to the vineyards. Nice for romantic retreat.

Reviewed on Apr 20, 2025

Opens in a new windowHotel Boutique Solaz Bella Vista de Colchagua
Hotel Boutique Vendimia Premium

Hotel Boutique Vendimia Premium

3.5 out of 5
Ismael Valdes 92, Santa Cruz, O'Higgins
$123 nightly
The price is $123 total per night from Nov 13 to Nov 14
$123 total
Nov 13 - Nov 14
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Museo de Colchagua and Plaza ...
9/10 Wonderful! (135 reviews)
Mauricio gave us a remote control for the gate and was an amazing host

Reviewed on Sep 19, 2025

Opens in a new windowHotel Boutique Vendimia Premium
Santa Cruz Plaza
Great for families

Santa Cruz Plaza

4 out of 5
Plaza De Armas 286, Santa Cruz, O'Higgins
$154 nightly
The price is $154 total per night from Nov 13 to Nov 14
$154 total
Nov 13 - Nov 14
Stay at this 4-star spa hotel in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (330 reviews)

Families like: Outdoor pool, kids club, babysitting, bicycle rentals

Travelers say...
No table in room, only one chair in room. Not able to sit with my wife to order a drink from the bar since we had no place to sit or place our bar food (no table)

Reviewed on Sep 25, 2025

Opens in a new windowSanta Cruz Plaza
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La Perla Hotel

La Perla Hotel

3.5 out of 5
El Rosal, Parcela 4, Lote A, Capellanía, Santa Cruz, O'Higgins
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo de Colchagua and Plaza ...
9/10 Wonderful! (99 reviews)
Nice stay

Reviewed on Apr 13, 2025

Opens in a new windowLa Perla Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Santa Cruz Flight and Hotel Packages

Santa Cruz flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Hotel Director Vitacura
Hotel Eco Boutique Bidasoa
ICON Hotel
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Need a Car For After Your Flight?

Lowest prices found within the past 13 hours. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Which airlines fly to Santa Cruz?
Lock in a fare with one of the 17 airlines that travel to Santa Cruz an enjoy an amazing new adventure. Carriers that come with top reviews include:

  • LATAM Airlines
  • Sky Airline
  • JetSMART

Where to stay in Santa Cruz
Start making those dreams about Santa Cruz come true by reserving your accommodations with Travelocity. With 37 terrific options at your fingertips, we know you'll find the perfect place to lay your head.Securing accommodations can often be a little tiresome. Make the process as easy as possible and check out some of our top suggestions, the Santa Cruz Plaza and the Casa Suiza.
Places to visit in Santa Cruz
Discover the protracted and interesting history of Plaza de Armas. Need some more ideas? A day touring Museo de Colchagua is a wonderful way to learn about regional history away from the crowded tourist sites. And there's more. A trip to Laura Hartwig Winery is a journey for your palate.
How to get through airport security fast when traveling to Santa Cruz
If you like the idea of spending more time at the airport bars and restaurants and less time at the security checkpoint on your way to Santa Cruz, follow these practical tips:

  • Keep your boarding pass and passport easily accessible. They'll be the first things you'll be asked for by security staff.
  • Coins, belts and keys are to be placed in a tub for X-raying. If you walk into the body scanner with these items, you'll be turned around and requested to remove them.
  • Laptops must be removed from their protective carriers and placed in a tub for inspection.
  • When it comes to flying with liquids or gels, each passenger is permitted a quart-sized clear resealable bag to keep containers no larger than 3.4 ounces (100 milliliters).
  • Give some thought to the type of footwear you want to fly in. Slippers are awesome because they're easy to take off for the airport security checks. Try wearing some on your next flight!
  • Some countries have strict biosecurity laws. Consider where you're headed to and whether or not you can travel with unpackaged foods.

Plane Tickets To Santa Cruz

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Santa Cruz. Browse through our inventory to explore a wide range of cheap flights to Santa Cruz to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Santa Cruz as you anxiously await to exit the plane and explore what Santa Cruz has to offer. Considering all the amazing local food and culture in Santa Cruz, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Santa Cruz to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Santa Cruz without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Santa Cruz with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Santa Cruz today!

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.