Explore 48 Luxury Hotels in Panama City
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Best Luxury Hotels in Panama City
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $213 total per night from Aug 1 to Aug 2
$213 total
Aug 1 - Aug 2
Total includes taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,002 reviews)
"I love the staff! Leonardo is the perfect host."
Reviewed on Jul 17, 2025
American Trade Hotel
Plaza Herrera Casco Viejo, Panama City, Panama
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $234 total per night from Aug 4 to Aug 5
$234 total
Aug 4 - Aug 5
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (539 reviews)
"Such a gorgeous heritage property in a quaint historic area. Staff were amazing too. Will definitely return for a longer stay."
Reviewed on Jul 10, 2025
JW Marriott Panama
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $223 total per night from Aug 1 to Aug 2
$223 total
Aug 1 - Aug 2
Total includes taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,004 reviews)
JW Marriott Experience
"The hotel was spotless, and the staff were friendly. It's a bit expensive, as I was expecting more of a luxury hotel. The only bad thing was the breakfast one morning, when everything was cold and the cup of coffee wasn't hot. The toast was hard as a rock, so it was a total disappointment for the ..."
Reviewed on Jul 18, 2025
Waldorf Astoria Panama
47th St. & Uruguay Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $237 total per night from Aug 8 to Aug 9
$237 total
Aug 8 - Aug 9
Total includes taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,002 reviews)
"Absolutely amazing from check in to check out."
Reviewed on Jul 17, 2025
Hilton Panama
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
$195 nightly
The price is $214 total per night from Aug 15 to Aug 16
$214 total
Aug 15 - Aug 16
Total includes taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,004 reviews)
"Staff was very friendly. Always greeted with a warm welcome. The lady that checked us in was very informative and answered all our questions. One negative was my husband had to fix our toilet because the chain was rusted and it wouldn’t flush. We wish they had a couple of bottles of water for the ..."
Reviewed on Jul 6, 2025
Las Americas Golden Tower Panama
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $163 total per night from Aug 22 to Aug 23
$163 total
Aug 22 - Aug 23
Total includes taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,002 reviews)
"I didn’t like that the pool wasn’t accessible in the morning hours…… everything else was amazing"
Reviewed on Jul 22, 2025
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
56 y 57 East Street, Obarrio, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Jul 28 to Jul 29
$175 total
Jul 28 - Jul 29
Total includes taxes and fees
This luxury hotel features a casino, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in ...
8.6/10 Excellent! (971 reviews)
Wonderful
"Lovely hotel"
Reviewed on Jul 19, 2025
Megapolis Hotel Panamá
Ave. Balboa al lado de Multicentro, 63, Panama City, Panamá Province
This luxury hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a children's club and a children's pool, and families ...
"This is THE place to stay in Panama City... it's location, friendly accommodating staff, and the amenities are fantastic. The rooms were wonderful, clean and bright. We tried Tauro (steakhouse) and the Bazaar - they were both delicious and the service excellent. We literally partied like rock stars ..."
Reviewed on Feb 24, 2021
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Panama City
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo, Panama City, Panama
$243 nightly
The price is $267 total per night from Jul 28 to Jul 29
$267 total
Jul 28 - Jul 29
Total includes taxes and fees
9/10 Wonderful! (949 reviews)
5 star hotels in Panama City
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe, Panama City, Panama
$293 nightly
The price is $322 total per night from Jul 27 to Jul 28
$322 total
Jul 27 - Jul 28
Total includes taxes and fees
9.8/10 Exceptional! (477 reviews)
Panama City Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Panama City luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Panama City to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Panama City will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Panama City, and plan your next opulent escape.
Panama City hotels essential information
Accommodation | 1,412 hotels |
|---|---|
Lowest Price | $84 |
Highest Price | $322 |
Popular hotels | JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, Las Americas Golden Tower Panama |
Popular Luxury Stays in Panama City
Recent Panama City Hotel Reviews By Fellow Wanderers
Hotel Riu Plaza Panama
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"We spent a fantastic 4 nights at RIU plaza. The staff had a great attitude and always ready to help. Arranging transportation was so easy right outside at the quality transfer desk, the staff and drivers were great especially Lionel. Hope to visit again in the near future ❤️"
A verified traveler stayed at Hotel Riu Plaza Panama
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An attraction
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Areas of Panama City
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