Explore top 2026 5 Star Hotels in Andean Natural Region

Name: Wake Medellin, a Member of Design Hotels
Price range: $226 total

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Top Andean Natural Region 5 Star hotels

The Click Clack Hotel Medellin

Calle 10B # 37-29 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$184 nightly

$184 total

Nov 16 - Nov 17

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and airport shuttle. ...

NH Collection Medellín Royal

Carrera 42 No 5 Sur 130 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$99 nightly

$99 total

Dec 13 - Dec 14

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

The Charlee Hotel

Calle 9a 37 16 Medellín

Fully refundableReserve now, pay when you stay

$171 nightly

$171 total

Dec 6 - Dec 7

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free ...

Medellin Marriott Hotel

Calle 1a Sur #43a-83 Medellín

Fully refundableReserve now, pay when you stay

$299 nightly

$299 total

Nov 28 - Nov 29

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

Binn Hotel

Carrera 25 No. 10-51 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$183 nightly

$183 total

Dec 16 - Dec 17

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (1,003 reviews)

"Place was very clean and neat. Exceeding our expectations. Staff was amazing they went avove and beyond to meet our needs. Highly recommend this hotel."

Reviewed on Nov 14, 2026

York Medellin, Curio Collection by Hilton

Carrera 43a 17sur 63 Medellín Antioquia

Fully refundableReserve now, pay when you stay

$229 nightly

$229 total

Nov 23 - Nov 24

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

9.6/10 Exceptional! (1,126 reviews)

"The hotel itself was clean and beautiful, and the overall appearance was very nice. However, the amenities were limited, and unfortunately, our experience was far from what we expected. At around 3 AM, there was a power emergency that left us without air conditioning and proper lighting. We had to ..."

Reviewed on Nov 14, 2026

Devú

# 9-32 Carrera 32d Medellín Antioquia

Fully refundableReserve now, pay when you stay

$173 nightly

$173 total

Nov 16 - Nov 17

This aparthotel features free WiFi in public areas, dry cleaning, and laundry facilities. Multilingual staff can provide around-the-clock assistance and concierge ...

Wake BioHotel, a Member of Design Hotels

25115 Calle 2 Sur Medellín Antioquia

Fully refundableReserve now, pay when you stay

$194 nightly

$194 total

Nov 29 - Nov 30

This hotel features 2 coffee shops/cafes and an outdoor pool. Enjoy the 24-hour gym and free perks like buffet breakfast and free self parking. You'll find a ...

Bosko

46,5 km From José María Córdoba Airport Guatapé Antioquia

Fully refundableReserve now, pay when you stay

$290 nightly

$290 total

Nov 16 - Nov 17

Ski-in/ski-out access, a full-service spa, and 2 outdoor pools are all featured at this smoke-free lodge. Traveling on business? Take advantage of the free WiFi ...

9.6/10 Exceptional! (216 reviews)

"Great place"

Reviewed on Nov 11, 2026

Wake Medellin, a Member of Design Hotels

Calle 10b #35-27 El Poblado Medellín Antioquia

Fully refundableReserve now, pay when you stay

$226 nightly

$226 total

Dec 13 - Dec 14

This hotel features a 24-hour gym, a hot tub, and a restaurant. Enjoy the sauna and perks like free self parking and free WiFi. A bar/lounge, a 24-hour front ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Andean Natural Region Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Andean Natural Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Andean Natural Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Andean Natural Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.