Explore top 2025 4 Star Hotels in Lake Nona Medical City
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Top Lake Nona Medical City 4 Star hotels
DoubleTree by Hilton Hotel Orlando at SeaWorld
10100 International Drive, Orlando, FL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Oct 10 to Oct 11
$123 total
Oct 10 - Oct 11
Total with taxes and fees
This smoke-free resort features 2 restaurants, 2 outdoor pools, and a 24-hour gym. There's fun for all ages with mini golf and a children's pool, and families ...
7.4/10 Good! (6,150 reviews)
"Good"
Reviewed on Sep 24, 2025
Marriott's Grande Vista
5925 Avenida Vista, Orlando, FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Oct 26 to Oct 27
$98 total
Oct 26 - Oct 27
Total with taxes and fees
This eco-certified hotel features a golf course, a full-service spa, and 3 restaurants. There's fun for all ages with mini golf and a children's pool, and barbecue ...
8.8/10 Excellent! (3,195 reviews)
"Clean room"
Reviewed on Sep 25, 2025
DoubleTree by Hilton Orlando Airport
5555 Hazeltine National Drive, Orlando, FL
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $109 total per night from Oct 3 to Oct 4
$109 total
Oct 3 - Oct 4
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi and a free airport shuttle. You'll appreciate ...
8.6/10 Excellent! (1,768 reviews)
"If someone is doing a digital check in, we should be notified that you still need a physical card get into the parking lot."
Reviewed on Sep 19, 2025
Hyatt Regency Orlando
9801 International Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $179 total per night from Sep 28 to Sep 29
$179 total
Sep 28 - Sep 29
Total with taxes and fees
A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this luxury hotel. Bring the family and enjoy the children's pool, free theme park ...
9/10 Wonderful! (1,754 reviews)
"Layout of the hotel."
Reviewed on Sep 23, 2025
Walt Disney World Swan
1200 Epcot Resort Blvd, Lake Buena Vista, FL
Fully refundableReserve now, pay when you stay
$259 nightly
The price is $291 total per night from Sep 28 to Sep 29
$291 total
Sep 28 - Sep 29
Total with taxes and fees
This smoke-free resort features a private beach, 3 hot tubs, and a restaurant. Bring the family and enjoy the children's pool, free theme park shuttle, and waterslide. ...
9/10 Wonderful! (1,912 reviews)
"I have stayed there before a few times and I love it."
Reviewed on Sep 20, 2025
DoubleTree by Hilton at the Entrance to Universal Orlando
5780 Major Blvd, Orlando, FL
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $114 total per night from Oct 12 to Oct 13
$114 total
Oct 12 - Oct 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. There's fun for all ages with a children's pool and an arcade/game room, and ...
8.4/10 Very Good! (6,684 reviews)
"Great stay! Will absolutely come back!"
Reviewed on Sep 22, 2025
Walt Disney World Dolphin
1500 Epcot Resort Blvd, Lake Buena Vista, FL
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $258 total per night from Sep 28 to Sep 29
$258 total
Sep 28 - Sep 29
Total with taxes and fees
A private beach, a full-service spa, and 3 outdoor pools are all featured at this smoke-free hotel. There's fun for all ages with a children's club and a children's ...
8.8/10 Excellent! (3,815 reviews)
"Lots to do on hotel property and nearby."
Reviewed on Sep 23, 2025
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
12401 International Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $108 total per night from Oct 19 to Oct 20
$108 total
Oct 19 - Oct 20
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 5 outdoor pools, and 2 outdoor tennis courts. Bring the family and enjoy the children's club, children's pool, ...
9/10 Wonderful! (2,309 reviews)
"Good location, gorgeous amenities"
Reviewed on Sep 23, 2025
Hyatt Regency Orlando International Airport
9300 Jeff Fuqua Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $191 total per night from Sep 29 to Sep 30
$191 total
Sep 29 - Sep 30
Total with taxes and fees
This eco-certified hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free ...
9.2/10 Wonderful! (3,608 reviews)
"Great rooms , efficient check in and bags brought up very quickly, very impressed"
Reviewed on Sep 22, 2025
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
8800 Vistana Centre Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $112 total per night from Oct 26 to Oct 27
$112 total
Oct 26 - Oct 27
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 6 outdoor pools, and 10 outdoor tennis courts. There's fun for all ages with a free kid's club and mini golf, and ...
9.2/10 Wonderful! (3,562 reviews)
"An amazing property. We will be going back."
Reviewed on Sep 24, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Lake Nona Medical City hotel reviews by fellow wanderers
Marriott's Grande Vista
5 out of 5
Posted 11 hours ago
Travelocity Verified Review
"Clean room"
A verified traveler stayed at Marriott's Grande Vista
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