Explore top 2026 4 Star Hotels in Florida Keys
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Top Florida Keys 4 Star hotels
Reefhouse Resort & Marina
103800 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
$259 nightly
The price is $286 total per night from Oct 13 to Oct 14
$286 total
Oct 13 - Oct 14
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and a marina. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Family-friendly ...
9.4/10 Exceptional! (1,546 reviews)
"Spacious room and beautiful property."
Reviewed on Oct 10, 2026
Baker's Cay Resort Key Largo, Curio Collection by Hilton
97000 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
$337 nightly
The price is $379 total per night from Oct 21 to Oct 22
$379 total
Oct 21 - Oct 22
Total with taxes and fees
A private beach, 2 restaurants, and 2 outdoor pools are all featured at this resort. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
8.6/10 Excellent! (1,183 reviews)
"We loved this place. Will definitely stay there again."
Reviewed on Oct 11, 2026
Hawks Cay Resort
61 Hawks Cay Blvd Marathon FL
Fully refundableReserve now, pay when you stay
$272 nightly
The price is $304 total per night from Oct 18 to Oct 19
$304 total
Oct 18 - Oct 19
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and a water park. Spend a day at the beach snorkeling, or relax with sun loungers and beach umbrellas. ...
8.2/10 Very Good! (1,003 reviews)
"Great stay! Property is well kept with many options for dining. Will definitely stay again"
Reviewed on Oct 11, 2026
Amara Cay Resort
80001 Overseas Hwy Islamorada FL
Fully refundableReserve now, pay when you stay
$204 nightly
The price is $230 total per night from Oct 20 to Oct 21
$230 total
Oct 20 - Oct 21
Total with taxes and fees
A private beach, 2 restaurants, and an outdoor pool are all featured at this resort. If you want to take your pet along, this pet-friendly property offers everything ...
8.8/10 Excellent! (1,319 reviews)
"Very clean resort. The pool was fabulous. The tiki bar was great. Stall friendly and helpful. Truly enjoyed my stay!"
Reviewed on Oct 6, 2026
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
84001 Overseas Hwy Islamorada FL
Fully refundableReserve now, pay when you stay
$294 nightly
The price is $330 total per night from Oct 18 to Oct 19
$330 total
Oct 18 - Oct 19
Total with taxes and fees
This Art Deco resort features a private beach, a marina, and 4 restaurants. Enjoy a day at the beach snorkeling, or relax with sun loungers. Families will appreciate ...
Islander Resort
82100 Overseas Highway Islamorada FL
Fully refundableReserve now, pay when you stay
$297 nightly
The price is $334 total per night from Oct 19 to Oct 20
$334 total
Oct 19 - Oct 20
Total with taxes and fees
A private beach, 3 restaurants, and 2 outdoor pools are all featured at this hotel. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Families ...
Playa Largo Resort & Spa, Autograph Collection
97450 Overseas Highway Key Largo FL
Fully refundableReserve now, pay when you stay
$312 nightly
The price is $351 total per night from Nov 1 to Nov 2
$351 total
Nov 1 - Nov 2
Total with taxes and fees
This luxury resort features a full-service spa, a marina, and 4 restaurants. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Relax with ...
9/10 Wonderful! (1,003 reviews)
"This was my second time in Playa Largo of many more to come. The property is beautiful and meticulously maintained. With plenty of amenities and food options I rarely leave the property. Very friendly staff from the front desk to the pool staff, everyone is friendly and welcoming. Would definitely ..."
Reviewed on Oct 10, 2026
Tranquility Bay Beachfront Hotel and Resort
2600 Overseas Hwy Marathon FL
Fully refundableReserve now, pay when you stay
$265 nightly
The price is $299 total per night from Oct 19 to Oct 20
$299 total
Oct 19 - Oct 20
Total with taxes and fees
This smoke-free hotel features a private beach, 3 outdoor pools, and a restaurant. Business travelers can take advantage of the free WiFi in public areas. Enjoy ...
8.8/10 Excellent! (1,006 reviews)
"Access to the beach for the kids"
Reviewed on Oct 10, 2026
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
1996 Overseas Highway Marathon FL
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $221 total per night from Oct 18 to Oct 19
$221 total
Oct 18 - Oct 19
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 4 restaurants. Traveling on business? Take advantage of the 3 conference rooms, along with ...
La Siesta Resort & Villas
80241 Overseas Highway Islamorada FL
$252 nightly
The price is $283 total per night from Nov 8 to Nov 9
$283 total
Nov 8 - Nov 9
Total with taxes and fees
The private beach and marina are among the highlights at this resort. Enjoy the outdoor pool and perks like a free area shuttle. There's a poolside bar on site, ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
4 Star Hotels Florida Keys
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent Florida Keys hotel reviews by fellow wanderers
Hawks Cay Resort
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Great stay! Property is well kept with many options for dining. Will definitely stay again"
A verified traveler stayed at Hawks Cay Resort
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