Book Hotels in Syracuse, MO

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Syracuse hotels

Comfort Inn Sedalia Station

Comfort Inn Sedalia Station

2.5 out of 5
3600 W Broadway Blvd Sedalia MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Dec 21 to Dec 22
$108 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Ok

Reviewed on Nov 29, 2025

Opens in a new windowComfort Inn Sedalia Station
Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

3 out of 5
103 E 4th St Sedalia MO
Fully refundable
$107 nightly
The price is $122 total per night from Jan 4 to Jan 5
$122 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
great service, beautiful facilities. we have stayed there a number of times and love it

Reviewed on Nov 29, 2025

Opens in a new windowHotel Bothwell Sedalia Central District, an Ascend Collection Hotel
Holiday Inn Express Boonville by IHG

Holiday Inn Express Boonville by IHG

2.5 out of 5
2419 Mid America Industrial Dr Boonville MO
Fully refundable
$129 nightly
The price is $144 total per night from Dec 7 to Dec 8
$144 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
The room was spotless. The staff was very nice and we didn't have any complications checking in very quick and sweet!

Reviewed on Nov 13, 2025

Opens in a new windowHoliday Inn Express Boonville by IHG
Best Western State Fair Inn

Best Western State Fair Inn

3 out of 5
3120 S Limit Sedalia MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $119 total per night from Dec 11 to Dec 12
$119 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the business ...
Great stay! clean, convenient, and safe! quiet, hot water!

Reviewed on Nov 24, 2025

Opens in a new windowBest Western State Fair Inn
Quality Inn & Suites Boonville - Columbia

Quality Inn & Suites Boonville - Columbia

2.5 out of 5
2427 Mid America Industrial Dr Boonville MO
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $83 total per night from Jan 5 to Jan 6
$83 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
An indoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like buffet breakfast and WiFi in public ...
It is an older building, but the room was clean and had had some renovations. The vanity in our bathroom was still very low, but the rest of the bathroom was newer. Our bed was comfortable and the heating unit kept the room warm. Our check in person was very nice and efficient. Breakfast was plentiful ...

Reviewed on Nov 26, 2025

Opens in a new windowQuality Inn & Suites Boonville - Columbia
Super 8 by Wyndham Boonville

Super 8 by Wyndham Boonville

2.5 out of 5
420 Americana Boonville MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $68 total per night from Jan 5 to Jan 6
$68 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Room was big and staff extremely friendly. Will stay again when meeting family.

Reviewed on Nov 26, 2025

Opens in a new windowSuper 8 by Wyndham Boonville
Days Inn by Wyndham Boonville

Days Inn by Wyndham Boonville

2 out of 5
2401 Pioneer St Boonville MO
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $47 total per night from Dec 6 to Dec 7
$47 total
Dec 6 - Dec 7
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Free self ...
convenient

Reviewed on Nov 29, 2025

Opens in a new windowDays Inn by Wyndham Boonville
Econo Lodge Truman Inn

Econo Lodge Truman Inn

2 out of 5
3501 W Broadway Blvd Sedalia MO
Fully refundableReserve now, pay when you stay
$62 nightly
The price is $71 total per night from Jan 1 to Jan 2
$71 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Business travelers can take advantage of the free WiFi in public areas. Enjoy the sauna and free perks like ...
Just needed a room for the night. It was ok

Reviewed on Nov 3, 2025

Opens in a new windowEcono Lodge Truman Inn
Motel 6 Sedalia, MO

Motel 6 Sedalia, MO

2 out of 5
3402 W Broadway Blvd Sedalia MO
Fully refundableReserve now, pay when you stay
$49 nightly
The price is $56 total per night from Dec 21 to Dec 22
$56 total
Dec 21 - Dec 22
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. A snack bar/deli, laundry facilities, and free newspapers are also on ...
The staff was great ad room was clean and easy to get to with my handicap

Reviewed on Nov 5, 2025

Opens in a new windowMotel 6 Sedalia, MO
Don't see what you're looking for?
See all available properties in Syracuse
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Syracuse?
Take some of the hassles out of traveling with kids by booking a family-friendly Syracuse hotel. From well-thought-out amenities to extra-helpful services, these stays offer perks that'll help make your getaway run like a dream: You'll be well taken care of at Unique Creekside Escape - Enjoy 300+ Goats!. It comes with a barbecue grill, internet access and a commitment to making families feel at home. Also look into Western Hills Motel. It comes with a swimming pool, a picnic area and plenty of opportunities to hang out together.
Where can I find cheap hotels in Syracuse?
At Travelocity you'll find really nice hotels in Syracuse at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Syracuse rather than in Syracuse. We may find you even better rates, too.
How do I find the best Syracuse hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Syracuse then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Syracuse?
The cheapest hotel in Syracuse is $47. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Syracuse?
There are 76 hotels in Syracuse on Travelocity.
What are the best hotels in Syracuse?
Syracuse has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Syracuse for you!
When is the best time to visit Syracuse?
If you want the joy of a fun-filled trip in peak season, visit Syracuse during March, April and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as August, October and December.
When is the cheapest time to stay in Syracuse?
Based on historic data is usually the cheapest month to visit Syracuse. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Syracuse?
There are multiple hotels in Syracuse that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Syracuse. We have plenty of kid-friendly hotels in Syracuse to choose from on Travelocity!
Why book a hotel in Syracuse through Travelocity?
Because we have the top hotels in Syracuse! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Syracuse on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Syracuse hotel reviews by fellow wanderers

American Inn Sedalia

American Inn Sedalia

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"The room s where clean."
A verified traveler stayed at American Inn Sedalia
American Inn Sedalia

Explore More Ways to Travel with Travelocity