Book Hotels in Syracuse, MO

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Syracuse hotels

Comfort Inn Sedalia Station

Comfort Inn Sedalia Station

2.5 out of 5
3600 W Broadway Blvd Sedalia MO
$118 nightly
The price is $134 total per night from Aug 24 to Aug 25
$134 total
Aug 24 - Aug 25
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"This was a great hotel, we spent a lot of time in the lobby area with our friends because it had a very inviting atmosphere.. The room was very clean and comfortable!"

Reviewed on Jul 29, 2026

Opens in a new windowComfort Inn Sedalia Station
Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

3 out of 5
103 E 4th St Sedalia MO
Fully refundable
$114 nightly
The price is $130 total per night from Aug 27 to Aug 28
$130 total
Aug 27 - Aug 28
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
"It keeps its old charm that takes you back to yesteryear. It's clean friendly and downtown in a walkable shopping area. Being old the rooms aren't overly large but they are comfortable. Breakfast had fresh cooked eggs."

Reviewed on Jul 26, 2026

Opens in a new windowHotel Bothwell Sedalia Central District, an Ascend Collection Hotel
Holiday Inn Express Boonville by IHG

Holiday Inn Express Boonville by IHG

2.5 out of 5
2419 Mid America Industrial Dr Boonville MO
Fully refundable
$136 nightly
The price is $152 total per night from Aug 23 to Aug 24
$152 total
Aug 23 - Aug 24
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"Great place to stay for the night"

Reviewed on Jul 28, 2026

Opens in a new windowHoliday Inn Express Boonville by IHG
Quality Inn & Suites Boonville - Columbia

Quality Inn & Suites Boonville - Columbia

2.5 out of 5
2427 Mid America Industrial Dr Boonville MO
Fully refundable
$116 nightly
The price is $131 total per night from Aug 13 to Aug 14
$131 total
Aug 13 - Aug 14
Total with taxes and fees
An indoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like buffet breakfast and WiFi in public ...
"liked everything staff was exceptional"

Reviewed on Jul 26, 2026

Opens in a new windowQuality Inn & Suites Boonville - Columbia
Days Inn by Wyndham Boonville

Days Inn by Wyndham Boonville

2 out of 5
2401 Pioneer St Boonville MO
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $47 total per night from Aug 2 to Aug 3
$47 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Free self ...
"We have stayed at this hotel a few times now. The rooms have always been clean. The AC was a bit noisy but it was working OT in this heat! The staff is always friendly. The area is not very busy and pretty quiet. They offer a light breakfast and a couple of well stocked vending machines in the lobby ..."

Reviewed on Jul 27, 2026

Opens in a new windowDays Inn by Wyndham Boonville
Motel 6 Sedalia, MO

Motel 6 Sedalia, MO

2 out of 5
3402 W Broadway Blvd Sedalia MO
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $64 total per night from Aug 25 to Aug 26
$64 total
Aug 25 - Aug 26
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. A snack bar/deli, laundry facilities, and free newspapers are also on ...
"They. Need to update"

Reviewed on Jul 26, 2026

Opens in a new windowMotel 6 Sedalia, MO
American Inn Sedalia

American Inn Sedalia

2.5 out of 5
1217 S Limit Ave Sedalia MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $63 total per night from Aug 24 to Aug 25
$63 total
Aug 24 - Aug 25
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the business center. The front ...
"Was a good hotel"

Reviewed on Jul 1, 2026

Opens in a new windowAmerican Inn Sedalia
Econo Lodge Truman Inn

Econo Lodge Truman Inn

2 out of 5
3501 W Broadway Blvd Sedalia MO
Fully refundable
$78 nightly
The price is $89 total per night from Aug 2 to Aug 3
$89 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Business travelers can take advantage of the free WiFi in public areas. Enjoy the sauna and free perks like ...
Opens in a new windowEcono Lodge Truman Inn
Best Western State Fair Inn

Best Western State Fair Inn

3 out of 5
3120 S Limit Sedalia MO
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $128 total per night from Aug 4 to Aug 5
$128 total
Aug 4 - Aug 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the business ...
Opens in a new windowBest Western State Fair Inn
Don't see what you're looking for?
See all available properties in Syracuse
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Syracuse?
Take some of the hassles out of traveling with kids by booking a family-friendly Syracuse hotel. From well-thought-out amenities to extra-helpful services, these stays offer perks that'll help make your getaway run like a dream: You'll be well taken care of at Unique Creekside Escape - Enjoy 300+ Goats!. It comes with a barbecue grill, internet access and a commitment to making families feel at home. Also look into Western Hills Motel. It comes with a swimming pool, a picnic area and plenty of opportunities to hang out together.
Where can I find cheap hotels in Syracuse?
At Travelocity you'll find really nice hotels in Syracuse at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Syracuse rather than in Syracuse. We may find you even better rates, too.
How do I find the best Syracuse hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Syracuse then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Syracuse?
The cheapest hotel in Syracuse is $47. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Syracuse?
There are 86 hotels in Syracuse on Travelocity.
What are the best hotels in Syracuse?
Syracuse has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Syracuse for you!
When is the best time to visit Syracuse?
If you want the joy of a fun-filled trip in peak season, visit Syracuse during March, April and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as August, October and December.
When is the cheapest time to stay in Syracuse?
Based on historic data is usually the cheapest month to visit Syracuse. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Syracuse?
There are multiple hotels in Syracuse that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Syracuse. We have plenty of kid-friendly hotels in Syracuse to choose from on Travelocity!
Why book a hotel in Syracuse through Travelocity?
Because we have the top hotels in Syracuse! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Syracuse on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Syracuse hotel reviews by fellow wanderers

Comfort Inn Sedalia Station

Comfort Inn Sedalia Station

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"This was a great hotel, we spent a lot of time in the lobby area with our friends because it had a very inviting atmosphere.. The room was very clean and comfortable!"
A verified traveler stayed at Comfort Inn Sedalia Station
Comfort Inn Sedalia Station

Explore More Ways to Travel with Travelocity