Explore 33 Luxury Hotels in Southwest

Name: Natchez Grand Hotel & Suites on the River
Price range: $132 total

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Best Luxury Hotels in Southwest

Duff Green Mansion

1114 First East Street Vicksburg MS

Fully refundableReserve now, pay when you stay

$126 nightly

$139 total

Dec 1 - Dec 2

Total with taxes and fees

An outdoor pool is featured at this bed & breakfast, along with a terrace and a garden. Enjoy the free full breakfast each morning. A business center, a library, ...

9.4/10 Exceptional! (993 reviews)

"Great stay! Great staff! Delicious food! Loved the tour given by a family member after breakfast!! Would highly recommend Duff Green Mansion and the city of Vicksburg‼️❤️"

Reviewed on Oct 26, 2026

The Guest House Historic Mansion

201 N. Pearl Street Natchez MS

$124 nightly

$139 total

Nov 8 - Nov 9

Total with taxes and fees

A restaurant and a bar/lounge are featured at this bed & breakfast. Families will appreciate the arcade/game room and picnic area. There's no skimping on freebies ...

9.2/10 Wonderful! (973 reviews)

"We really enjoyed our stay. The room was spotless, the cookies were delicious and the staff was as Friendly as could be. Breakfast was delicious. We were sorry to hear they don’t offer dinner anymore, but the staff helped us find a nearby restaurant."

Reviewed on Nov 1, 2026

Steele Cottage

1201 Adams Street Vicksburg MS

Fully refundableReserve now, pay when you stay

$91 nightly

$100 total

Nov 5 - Nov 6

Total with taxes and fees

A restaurant and a bar/lounge are featured at this guesthouse. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

9/10 Wonderful! (199 reviews)

"The tour of the Duff mansion was exquisite & so were the accommodations!! Authentic furniture & furnishings of the 1800s. The gal tour guide went way beyond in details & historic retelling of stories; & our welcome was very warm with a wine mtg at the mansion. The breakfast was fancy & super good. ..."

Reviewed on Oct 24, 2026

La Quinta Inn & Suites by Wyndham Canton MS

152 Soldier Colony Rd Canton MS

Fully refundableReserve now, pay when you stay

$104 nightly

$113 total

Dec 3 - Dec 4

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. Traveling for business? Take advantage of the 24-hour business center, laundry service, and conference ...

7.2/10 Good! (719 reviews)

"Room was stanky"

Reviewed on Nov 2, 2026

Hilton Garden Inn Jackson Downtown

235 W Capitol St Jackson MS

$93 nightly

$104 total

Nov 10 - Nov 11

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a business center, and a coffee ...

6.8/10 (1,002 reviews)

"Good"

Reviewed on Nov 3, 2026

Best Western Airport Inn

257 S Pearson Road Pearl MS

Fully refundableReserve now, pay when you stay

$66 nightly

$74 total

Nov 10 - Nov 11

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour ...

Econo Lodge Vicksburg

3959 Clay Street Vicksburg MS

Fully refundableReserve now, pay when you stay

$70 nightly

$77 total

Nov 5 - Nov 6

Total with taxes and fees

A gym, free self parking, and free newspapers are featured at this hotel. WiFi in public areas is free. A safe deposit box is provided and the front desk is ...

Natchez Grand Hotel & Suites on the River

111 North Broadway Street Natchez MS

Fully refundableReserve now, pay when you stay

$118 nightly

$132 total

Nov 24 - Nov 25

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center, express check-out, and airport ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southwest

Gabba Chaud Inn

1201 Openwood Ln Vicksburg MS

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10/10 Exceptional! (1 review)

Southwest Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southwest luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southwest to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southwest will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southwest, and plan your next opulent escape.

Southwest hotels essential information

Accommodation	901 hotels
Lowest Price	$74
Highest Price	$269
Popular hotels	The Guest House Historic Mansion, Duff Green Mansion, Best Western Airport Inn, Econo Lodge Vicksburg, Steele Cottage, La Quinta Inn & Suites by Wyndham Canton MS, Natchez Grand Hotel & Suites on the River , Hilton Garden Inn Jackson Downtown