Get your travels off to the best possible start by knowing a thing or two about Santa Ana before you jet off.
From the center of Panama City, you'll need to make your way southwest for 2 miles (3 kilometers) to reach this neighborhood.
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Wander wisely in Santa Ana by staying somewhere close by. This lovely neighborhood has 24 properties to select from within walking distance.
Check out the Las Clementinas (Casco Antiguo, Calle 11 Y Ave B) and the American Trade Hotel (Plaza Herrera Casco Viejo). Our top Santa Ana picks, they offer a wonderful night's sleep in a handy location.
Landing at Tocumen International Airport (PTY)? Santa Ana is only 13 miles (21 kilometers) from here. Grab a coffee, hail down a cab and you'll be there in no time at all!
Thinking about taking a road trip during your stay in Santa Ana? A rental car will surely be helpful here. Look through some of the options on Travelocity, select your favorite and start organizing your road trip playlist!
Getting in by plane? Fox Rental Cars at Tocumen International Airport is the vendor to visit after collecting your baggage.
Budget is located in the middle of the city at Tocumen International Airport. This makes it an easy option for those staying central.
Metropolitan Cathedral of Panama is one of this area's most notable attractions — and best of all, it's a very short drive from the center of town.
Boasting numerous fascinating exhibits, collections and programs, Museum of Natural Science inspires, educates and entertains the curious visitors who stream through its doors.
Seeking more nearby options?
You'll enjoy exploring Independence Square, a historic piazza that attracts locals and visitors alike.
But that's not all there is.
Make a point of stopping to see and learn the background of Palacio de las Garzas, a historic civic building.
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^Savings based on all package bookings made with Flight + Hotel on Travelocity.com from January 1, 2018 to December 31, 2018, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.