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Argentina's national capital, Buenos Aires, is filled with interesting neighborhoods to base yourself in, including Palermo, which you'll find 3 miles (5 kilometers) to the northwest of the city's downtown area.
If you'd like to spend some time in Buenos Aires, you may appreciate knowing that there are a good range of popular attractions, including the Teatro Colon, Casa Rosada and Obelisco.
If you and your travel buddies are making your way to Palermo, the Four Seasons Hotel Buenos Aires and Palacio Duhau - Park Hyatt Buenos Aires are all within a short stroll of the Japanese Garden. Additionally, the Urbanica The Suites Hotel and Espacia Suites are all close to the Tierra Santa, should you prefer.
Travelocity's user-friendly hotels page features a good range of Buenos Aires accommodations.