Deals on vacations and trips to O Brien

Save when you book O Brien package deals

Choose two or more items and save on your trip:

O Brien flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
Nature Coast Inn and Cottages

Nature Coast Inn and Cottages

3 out of 5
Price was $411, price is now $395 per person
$395
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Denver (DEN) to Gainesville (GNV)
An outdoor pool, free self parking, and laundry facilities are featured at this guesthouse. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including food and water bowls. The front desk is staffed around-the-clock and barbecue grills are on offer.
Nature Coast Inn and Cottages

Nature Coast Inn and Cottages

3 out of 5
Price was $549, price is now $477 per person
$477
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Denver (DEN) to Gainesville (GNV)
An outdoor pool, free self parking, and laundry facilities are featured at this cottage. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including food and water bowls. The front desk is staffed around-the-clock and barbecue grills are on offer.
Howard Johnson by Wyndham Ocala FL I-75

Howard Johnson by Wyndham Ocala FL I-75

3 out of 5
Price was $684, price is now $636 per person
$636
per person
Oct 8 - Oct 12
found 17 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Gainesville (GNV)
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Relax with a drink at the bar/lounge and enjoy free perks like continental breakfast and free self parking.

Top O Brien hotels deals

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

O'Brien FL
$356 nightly
The price is $387 total per night
$387 total
Aug 26 - Aug 27
Total with taxes and fees
A garden, express check-in, and express check-out are available at this vacation home. Laundry facilities and barbecue grills are also provided.
Kitchen
Washer
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
Get rates
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and barbecue grills are available on site.
Kitchen
Washer
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr Lake City FL
Free Cancellation
Reserve now, pay when you stay
$81 nightly
The price is $91 total per night
$91 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
$95 nightly
The price is $107 total per night
$107 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

3 out of 5
165NW CALI DRIVE Lake City FL
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $101 total per night
$101 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like on-the-go breakfast and free self parking.
Pool
Breakfast included
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90 Lake City FL
Free Cancellation
$93 nightly
The price is $104 total per night
$104 total
Aug 31 - Sep 1
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in O Brien
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to O Brien?
$395 is all you need to spend for a memorable vacation in O Brien. Bundle your flights and hotel into a vacation package with Travelocity and see the savings add up. With prices this good, you'll want to start packing your suitcase now!
How long should my O Brien vacation be?
Many travelers choose to spend about 5 nights in O Brien. But that's only a guide. Whether you prefer to stay for a couple of days or a couple of weeks, you'll love exploring all the amazing things that this destination has to offer.
Where can I get the best vacation package deals for O Brien?
You'll come across an amazing range of O Brien package deals on Travelocity. With 400 airlines and 1,000,000 properties across the globe, organizing your dream vacation will be easy.
Why should I purchase my O Brien vacation package with Travelocity?
Because life is all about the journey, and we have everything you need to help you on your way. With our excellent service and Price Match Guarantee, you can organize your trip with confidence. What's more, you can rest easy on the road knowing you can reach us with our round-the-clock support.
Can I save on my O Brien car rental if I combine it with my hotel or flight?
With an O Brien vacation package, you can combine your hotel, flight and car bookings and save a ton. If you're in the mood to discover the best of this fantastic region, why not start with University of Florida? This renowned attraction is 45 mi from O Brien. With your own rental car, you'll be there in no time.
Which airport is best for O Brien?
One of your top options is Gainesville Regional Airport (GNV), which you'll find 45 mi southeast of downtown O Brien. Your other choice is Valdosta Regional Airport (VLD), 55 mi away from central O Brien).
Where should I stay when visiting O Brien?
Many people opt to check in to the Pet-Friendly Florida Escape w/ Patio & Fire Pit!. It's a terrific base for your O Brien getaway.

Photos of local treasures

Browse O Brien vacation photos for more inspiration

A calm river with clear water, surrounded by dense trees and rocky banks.
A clear blue pond surrounded by dense forest.
A calm river surrounded by trees reflecting in the water.
A calm river with trees reflecting the sunlight.
A swampy area with a calm water body surrounded by various trees and vegetation.