Book Hotels in Mayo, SC

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Sep 11 - Sep 13
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Top Mayo hotels

AC Hotel by Marriott Spartanburg

AC Hotel by Marriott Spartanburg

3.5 out of 5
225 West Main Street Spartanburg SC
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $165 total per night from Sep 13 to Sep 14
$165 total
Sep 13 - Sep 14
Total with taxes and fees
This smoke-free hotel features 3 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in ...
"very basic like out of a box or Walmart Nothing special or memorable"

Reviewed on Aug 31, 2026

Opens in a new windowAC Hotel by Marriott Spartanburg
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

2.5 out of 5
161 Sha Ln Spartanburg SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Oct 4 to Oct 5
$106 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"It was a great place to stay clean, spacious, food was great, staff was friendly and nice and cool room"

Reviewed on Sep 6, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites Spartanburg-North by IHG
Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall

2.5 out of 5
458 West Blackstock Road Spartanburg SC
Fully refundable
$91 nightly
The price is $101 total per night from Sep 27 to Sep 28
$101 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Breakfast is your traditional convenience type foods. Eggs, bagels, fruit and yogurt"

Reviewed on Sep 6, 2026

Opens in a new windowComfort Suites At WestGate Mall
Best Western Spartanburg Northwest

Best Western Spartanburg Northwest

3 out of 5
110 Mobile Dr Spartanburg SC
$93 nightly
The price is $105 total per night from Sep 20 to Sep 21
$105 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Our room was clean and neat. Did not smell at all. Staff at checkin was a little brusque and less than welcoming but okay. Breakfast was very good, one of the better hotel breakfasts we’ve had. Plenty of parking. While we liked this hotel and would consider staying here again, we probably won’t. ..."

Reviewed on Sep 6, 2026

Opens in a new windowBest Western Spartanburg Northwest
Spartanburg Marriott

Spartanburg Marriott

3.5 out of 5
299 North Church Street Spartanburg SC
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $131 total per night from Sep 13 to Sep 14
$131 total
Sep 13 - Sep 14
Total with taxes and fees
This smoke-free hotel features 3 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free ...
Opens in a new windowSpartanburg Marriott
WoodSpring Suites Spartanburg - Duncan

WoodSpring Suites Spartanburg - Duncan

2.5 out of 5
255 Frontage Rd. Duncan SC
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from Sep 7 to Sep 8
$72 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Free parking and laundry facilities are also offered on site.
Opens in a new windowWoodSpring Suites Spartanburg - Duncan
Rodeway Inn Expo Center

Rodeway Inn Expo Center

2 out of 5
2070 New Cut Rd Spartanburg SC
Fully refundable
$57 nightly
The price is $64 total per night from Sep 27 to Sep 28
$64 total
Sep 27 - Sep 28
Total with taxes and fees
This motel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
Opens in a new windowRodeway Inn Expo Center
Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85

2 out of 5
820 Hospitality Drive Spartanburg SC
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $64 total per night from Oct 4 to Oct 5
$64 total
Oct 4 - Oct 5
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...
Opens in a new windowMotel 6 Spartanburg, Sc – Northwest / Business 85
Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg

3 out of 5
9027 Fairforest Rd Spartanburg SC
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $121 total per night from Sep 20 to Sep 21
$121 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowFour Points by Sheraton Spartanburg
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Mayo?
Great private home in convenient location is a great option for families on their way to Mayo. With useful amenities like a fireplace, this kid-friendly retreat makes guests of all ages feel at home.
Where can I find cheap hotels in Mayo?
At Travelocity you'll find really nice hotels in Mayo at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Mayo rather than in Mayo. We may find you even better rates, too.
How do I find the best Mayo hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Mayo then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Mayo?
The cheapest hotel in Mayo is $64. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Mayo?
There are 499 hotels in Mayo on Travelocity.
What are the best hotels in Mayo?
Mayo has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Mayo for you!
When is the best time to visit Mayo?
If you want the joy of a fun-filled trip in peak season, visit Mayo during March, April and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Mayo?
Based on historic data is usually the cheapest month to visit Mayo. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Mayo?
There are multiple hotels in Mayo that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Mayo. We have plenty of kid-friendly hotels in Mayo to choose from on Travelocity!
Why book a hotel in Mayo through Travelocity?
Because we have the top hotels in Mayo! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Mayo on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Mayo hotel reviews by fellow wanderers

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"It was a great place to stay clean, spacious, food was great, staff was friendly and nice and cool room"
A verified traveler stayed at Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG