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21c Museum Hotel Louisville

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Front of property
Fountain
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Breakfast, lunch, dinner and brunch served
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, 21c Museum Hotel
    ‪1 min walk‬
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, Kentucky Bourbon Trail Visitor Center
    ‪5 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪10 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(31 reviews)
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free WiFi

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(73 reviews)
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.2 out of 10
Wonderful
(35 reviews)
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Suite (Atrium)

A hotel room with a bed, desk, chair, dresser, and a sofa.

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(2 reviews)
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Apartment, 1 Double Bed (Rooftop)

A modern interior with a dining area, a patterned bench, and a large window with a city view.

Apartment, 1 Double Bed (Rooftop)

10.0 out of 10
Exceptional
(1 review)
  • City view
  • Sleeps 4
  • 1 Double Bed
  • Free WiFi

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About the neighborhood

Louisville

Downtown Louisville stay.A stay at this Downtown Louisville hotel places you steps from Louisville Slugger Museum and a 5-minute walk from Kentucky Bourbon Trail Visitor Center. KFC Yum Center and Ohio River Valley are also within half a mile (1 km).

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.1 miles
  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Kentucky Bourbon Trail Visitor Center - 5 min walk - 0.3 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Thelma's Deli - ‬7 min walk
  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Swizzle - ‬7 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk

About this property

21c Museum Hotel Louisville

4.5-star luxury hotel near KFC Yum Center
21c Museum Hotel Louisville offers its guests a full-service spa and a 24-hour fitness center. There's a restaurant on site. You can enjoy a drink at the bar/lounge. A computer station is on site, and both WiFi and wired Internet are free in public spaces.

A 24-hour business center, meeting rooms, and limo/town car service are available. Event space at this hotel measures 5000 square feet (465 square meters) and includes conference space. Spa services, multilingual staff, and gift shops/newsstands are also featured at the luxury 21c Museum Hotel Louisville. Parking is available for a fee.

This 4.5-star Louisville hotel is smoke free.

  • 1 building
  • 91 guestrooms or units
  • 4 levels
  • Meeting rooms
  • 5000 sq ft of conference space
  • 465 sq m of conference space
  • Built in 2006
  • Charging station for electric cars
  • Business center (24 hours)
  • Conference space
  • Breakfast available (surcharge)
  • Coffee in lobby
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Staff is multilingual
  • Storage area for luggage
  • Front-desk safe
  • Car service
  • Tour and ticket information
  • Concierge
  • Gift shop
  • ATM
  • Bellhop
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Dining venue
21c Museum Hotel Louisville offers 91 accommodations with minibars and laptop-compatible safes. Beds feature down comforters and premium bedding. 50-inch LCD televisions come with premium cable channels. Bathrooms include bathrobes, designer toiletries, complimentary toiletries, and hair dryers.

This Louisville hotel provides complimentary wired and wireless Internet access. Business-friendly amenities include desks along with free local calls (restrictions may apply). Additionally, rooms include espresso makers and complimentary bottled water. In-room massages and hypo-allergenic bedding can be requested. Housekeeping is provided daily.

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.

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Property amenities

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

Room amenities

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 40.00 per accommodation, per stay
  • Weight limit: 50 lbs per pet
  • Food and water bowls are available
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are available for USD 30.0 per night.
  • Free cribs (infant beds)!

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5.00 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
Charges for extra guests may apply and vary according to property policy.
A credit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation. This property accepts Visa, Mastercard, American Express, and Discover. Cash is not accepted. 
    For guests' safety, the property includes a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards in each accommodation. This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
21c Museum Louisville Mgallery
21c Museum Louisville
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21c Museum Hotel Louisville MGallery
21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

How close is 21c Museum Hotel Louisville to the airport?

21c Museum Hotel Louisville is 7.1 mi (10-min drive) away from the Louisville Intl. Airport (SDF) airport, the closest popular airport to the property.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Jun 10, 2026, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Jul 3, 2026 start from $184, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21c Museum Hotel Louisville have an airport shuttle?

Airport shuttle services are not available at 21c Museum Hotel Louisville.

Does 21c Museum Hotel Louisville offer free breakfast?

Free breakfast isn’t provided at 21c Museum Hotel Louisville, but full breakfast is offered for a fee of between USD 5 and 25 per person. It's available on weekdays from 7:00 AM to 10:00 AM and weekends from 8:00 AM to 1:00 PM.

Is there a casino at 21c Museum Hotel Louisville?

No, there is no casino at this hotel, but Horseshoe Southern Indiana Casino (22-min drive) is nearby.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

Is there free parking at 21c Museum Hotel Louisville?

Free parking is not available at this hotel. Valet parking is available for USD 32 per night.

Does 21c Museum Hotel Louisville have a pool?

21c Museum Hotel Louisville does not have a pool.

Does 21c Museum Hotel Louisville have a restaurant?

21c Museum Hotel Louisville is home to Proof on Main, which features light fare and brunch.

Does 21c Museum Hotel Louisville have a spa?

Pamper yourself with a day at 21c Spa, where you can enjoy Swedish massages.

How close is 21c Museum Hotel Louisville to downtown Louisville?

21c Museum Hotel Louisville is 0.4 mi away from Louisville.

21c Museum Hotel Louisville Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 775 out of 1000 reviews
Rating 8 - Good. 126 out of 1000 reviews
Rating 6 - Okay. 61 out of 1000 reviews
Rating 4 - Poor. 20 out of 1000 reviews
Rating 2 - Terrible. 18 out of 1000 reviews

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

Reviews

Verified

6/10 Okay

Laurie Beth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was wonderful - unfortunately our vehicle was broken into in the parking garage but the hotel staff helped us clean up the glass and cover the window and took a report. Bar staff was super fun and friendly and loved the overall vibe.
Stayed 1 night in May 2026
Verified

10/10 Excellent

Kristin Woxland

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Lovely hotel. Would stay there again.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Brent

Liked: Cleanliness, amenities, property conditions & facilities
Nice room and close to all the distilleries. Great restaurant on site as well!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Meredith

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Salvatore

Liked: Cleanliness, amenities, property conditions & facilities
Clean hotel…very cool vibe!!!
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Dean

Liked: Cleanliness, staff & service, amenities
Great room and amenities.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Amanada

Liked: Cleanliness, amenities, property conditions & facilities
Large spacious room and super comfortable bed Fascinating art and super bar and restaurant too Great service from all staff
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities
The staff was super friendly
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

MARC

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms and staff were great and the penguins were alive.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Madeline

Liked: Cleanliness, amenities, property conditions & facilities
Location and the staff was fabulous.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Rachel

Liked: Cleanliness, amenities, property conditions & facilities
Great room, super kind staff
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Joshua

Liked: Cleanliness, property conditions & facilities
This was an amazing hotel! Loved all the art and the bed was super comfortable. Hope to return one day!
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Karen

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Fun hotel, lots of interesting art, very comfortable, excellent staff
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Michael

Interesting Ambiente, very knowledgeable and friendly staff, great bar and good food in the restaurant with special choices.
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

pamela

Liked: Cleanliness, property conditions & facilities
Lovely comfortable place to stay !
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Douglas

Liked: Cleanliness, staff & service, amenities
clean rooms, outgoing and friendly staff. The vibe is warm and fun, love the penguins
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Anatole

Liked: Cleanliness, amenities, property conditions & facilities
Excellent place.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Thea

Liked: Cleanliness, amenities, property conditions & facilities
Great atmosphere, love the art that surrounds you at every turn
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Jeannie

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, art work is beautiful, friendly staff .
Stayed 1 night in Jan 2026
Verified

8/10 Good

Stacy

Liked: Cleanliness, amenities, property conditions & facilities
Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

JEFF

Liked: Cleanliness, amenities, property conditions & facilities
Fantastic, caring staff in an artsy and fun environment.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Lorie

Liked: Cleanliness, staff & service, amenities
All the staff were great! The rooms were clean the coffee was great. I would stay here again.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Erica

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved our stay, would definitely plan to come back if we are ever in the area again.
Stayed 1 night in Oct 2025
Verified

10/10 Excellent

Amy

Liked: Cleanliness, staff & service, property conditions & facilities
Great location. Not your typical hotel decor!
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Tammy

Liked: Cleanliness, amenities, property conditions & facilities
Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!
Stayed 1 night in Dec 2025

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