Book a hotel near Fort Defiance State Park, Cairo
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Top hotels close to Fort Defiance State Park

Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Free Cancellation
Reserve now, pay when you stay
4.85 mi from Fort Defiance State Park
$69 nightly
The price is $76 total per night
$76 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free full breakfast each morning. A picnic area is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly

La Center Motel
474 W Kentucky Dr, La Center, KY
10.88 mi from Fort Defiance State Park
Free WiFi in public areas is available at this hotel. Take advantage of the free self parking.
Parking included
Free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
10.88 mi from Fort Defiance State Park
$55 nightly
The price is $61 total per night
$61 total
Oct 19 - Oct 20
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.
Breakfast included
Pet friendly

Quality Inn Charleston - Sikeston
102 Drake St, I-57 Exit 10, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
12.55 mi from Fort Defiance State Park
$66 nightly
The price is $73 total per night
$73 total
Oct 21 - Oct 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business center and free internet in public areas. A safe deposit box is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly

Peaceful secluded cabin located near Horseshoe Lake
13.12 mi from Fort Defiance State Park
$168 nightly
The price is $178 total per night
$178 total
Oct 15 - Oct 16
Total with taxes and fees
This cabin features barbecue grills.
Kitchen
Pet friendly

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
16.21 mi from Fort Defiance State Park
This vacation home features a garden, laundry facilities, and barbecue grills.
Breakfast included
Kitchen

Cozy cabins on beautiful Horseshoe Lake
17.13 mi from Fort Defiance State Park
$124 nightly
The price is $131 total per night
$131 total
Oct 19 - Oct 20
Total with taxes and fees
Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Air conditioning
Lake view

The Rested Duck Mallard Room
17.13 mi from Fort Defiance State Park
$124 nightly
The price is $131 total per night
$131 total
Oct 17 - Oct 18
Total with taxes and fees
Stay at this cabin in Alexander County. Enjoy air conditioning.
Air conditioning

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
19.46 mi from Fort Defiance State Park
This vacation home features a garden, laundry facilities, and barbecue grills.
Kitchen
Washer

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
22.32 mi from Fort Defiance State Park
$84 nightly
The price is $96 total per night
$96 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.
Pool
Breakfast included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
22.34 mi from Fort Defiance State Park
$63 nightly
The price is $72 total per night
$72 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
22.55 mi from Fort Defiance State Park
$90 nightly
The price is $103 total per night
$103 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included
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See all available properties in Fort Defiance State Park
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Fort Defiance State Park hotels essential information
Accommodation | 168 hotels |
---|---|
Lowest Price | $61 |
Highest Price | $178 |
Popular hotels | Quality Inn Cairo I-57, Super 8 by Wyndham Charleston/Sikeston East MO, La Center Motel, Peaceful secluded cabin located near Horseshoe Lake , Quality Inn Charleston - Sikeston, Cozy cabins on beautiful Horseshoe Lake, Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286, The Rested Duck Mallard Room, Days Inn and Suites by Wyndham Sikeston, Welcome campers, hikers, fishermen, girls' weekend wine getaways!!, Drury Inn & Suites Sikeston, MO, Best Western Plus Sikeston |
Recent Fort Defiance State Park hotel reviews by fellow wanderers

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"It was a good place to stay would definately go back someday"
A verified traveler stayed at Welcome campers, hikers, fishermen, girls' weekend wine getaways!!