Explore 12 Luxury Hotels in Florence

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Best Luxury Hotels in Florence

The Mantissa Hotel

130 East Carolina Ave, Hartsville, SC

Fully refundableReserve now, pay when you stay

$144 nightly

$161 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9/10 Wonderful! (265 reviews)

What an unexpected treasure! The Mantissa is a beautiful property, ideally located in quaint downtown Hartsville close to shopping and dining. Great area to walk, or enjoy the YMCA across the street. The rooms are huge, but comfortable and well appointed. Worth going a bit out of your way!

Reviewed on Oct 15, 2025

Hotel Florence, Tapestry Collection by Hilton

126 W Evans St, Florence, SC

Fully refundableReserve now, pay when you stay

$130 nightly

$146 total

Nov 16 - Nov 17

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (592 reviews)

I stayed at Hotel Florence last year, and had the same issue then as I had this year: My room was not cleaned. I stayed two nights, and had to ask for fresh towels at the front desk that evening (because of course cleaning crew were no longer on site and no other services were available). The hotel ...

Reviewed on Oct 23, 2025

Days Inn by Wyndham Florence/I-95 North

2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC

Fully refundableReserve now, pay when you stay

$60 nightly

$67 total

Nov 22 - Nov 23

Total with taxes and fees

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...

6.6/10 (1,001 reviews)

Pleasant

Reviewed on Oct 22, 2025

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard, Florence, SC

Fully refundableReserve now, pay when you stay

$56 nightly

$63 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

6.6/10 (1,000 reviews)

Very clean

Reviewed on Oct 19, 2025

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr, Florence, SC

Fully refundableReserve now, pay when you stay

$64 nightly

$72 total

Oct 27 - Oct 28

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

6.6/10 (1,001 reviews)

Friendly staff clean room

Reviewed on Oct 21, 2025

Days Inn by Wyndham Dillon

823 Radford Blvd, Dillon, SC

Fully refundableReserve now, pay when you stay

$55 nightly

$62 total

Oct 28 - Oct 29

Total with taxes and fees

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like on-the-go breakfast and ...

5.4/10 (844 reviews)

Great place

Reviewed on Oct 16, 2025

Clarion Inn & Suites

1819 West Lucas Street, Building A, Florence, SC

Fully refundableReserve now, pay when you stay

$53 nightly

$59 total

Nov 7 - Nov 8

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like on-the-go breakfast and free self parking. A business ...

4.4/10 (288 reviews)

The property is in flux as the rooms are modified into spacious suites. Should be great when complete, but the pool, the breakfast and even the bulbs in some room lamps were missing, as was the battery to one of the TV's. VERY nice desk personnel, however, and a great rate for our clean, large room ...

Reviewed on Sep 4, 2025

Baymont Inn & Suites Florence by Wyndham

1826 W Lucas Street, Florence, SC

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

I made a reservation in February for Labor Day weekend reserved 3 rooms of 2 beds and pull out sofa bed. Was told that only 2 of those rooms exist at this location. Then said Nevermind we do have that. They planned on putting a mattress on the floor of a king room that they were in the process of ...

Reviewed on Sep 4, 2024

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Florence Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florence luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Florence to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Florence will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florence, and plan your next opulent escape.

Florence hotels essential information

Accommodation	363 hotels
Lowest Price	$59
Highest Price	$161
Popular hotels	The Mantissa Hotel, Days Inn by Wyndham Dillon, Hotel Florence, Tapestry Collection by Hilton, Days Inn by Wyndham Florence/I-95 North, Baymont Inn & Suites Florence by Wyndham, Clarion Inn & Suites, Red Roof Inn Florence - Civic Center, Days Inn by Wyndham Florence Near Civic Center