Explore 12 Luxury Hotels in Florence
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Best Luxury Hotels in Florence
The Mantissa Hotel
130 East Carolina Ave Hartsville SC
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $146 total per night from Feb 1 to Feb 2
$146 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...
9/10 Wonderful! (272 reviews)
This was an outstanding hotel We will stay again when in town
Reviewed on Jan 18, 2026
Hotel Florence, Tapestry Collection by Hilton
126 W Evans St Florence SC
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $146 total per night from Feb 12 to Feb 13
$146 total
Feb 12 - Feb 13
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
8.8/10 Excellent! (615 reviews)
Didn't stay long enough to try any of the amenities that they offer.
Reviewed on Jan 11, 2026
Quality Inn & Suites
817 Radford Blvd Dillon SC
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $88 total per night from Feb 22 to Feb 23
$88 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the express ...
7.2/10 Good! (773 reviews)
The friendliest staff and cleanest hotel by far I have ever visited.
Reviewed on Jan 17, 2026
Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $74 total per night from Feb 9 to Feb 10
$74 total
Feb 9 - Feb 10
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
6.8/10 (1,000 reviews)
Very friendly and courteous lady at check in. Room was clean, window heat/cool unit worked.Would appreciate a larger than 1"x 2" piece of soap and a more friendly TV guide service
Reviewed on Jan 18, 2026
Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $66 total per night from Jan 28 to Jan 29
$66 total
Jan 28 - Jan 29
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
6.6/10 (1,000 reviews)
Good room, great price
Reviewed on Jan 17, 2026
Red Roof Inn Florence - Civic Center
2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $63 total per night from Feb 1 to Feb 2
$63 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
6.6/10 (1,001 reviews)
Room was good. No microwave tho. Staff was very courteous and helpful
Reviewed on Jan 9, 2026
Days Inn by Wyndham Dillon
823 Radford Blvd Dillon SC
$60 nightly
The price is $67 total per night from Feb 18 to Feb 19
$67 total
Feb 18 - Feb 19
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like on-the-go breakfast and ...
5.4/10 (875 reviews)
Really enjoyed my stay
Reviewed on Dec 6, 2025
Clarion Inn & Suites Florence - Darlington
1819 West Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$52 nightly
The price is $58 total per night from Jan 30 to Jan 31
$58 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like on-the-go breakfast and free self parking. A business ...
4.4/10 (304 reviews)
NICE ROOM
Reviewed on Dec 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Florence Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florence luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Florence to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Florence will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florence, and plan your next opulent escape.
Florence hotels essential information
Accommodation | 375 hotels |
|---|---|
Lowest Price | $58 |
Highest Price | $146 |
Popular hotels | The Mantissa Hotel, Days Inn by Wyndham Dillon, Hotel Florence, Tapestry Collection by Hilton, Days Inn by Wyndham Florence/I-95 North, Clarion Inn & Suites Florence - Darlington, Red Roof Inn Florence - Civic Center, Days Inn by Wyndham Florence Near Civic Center, Quality Inn & Suites |
Popular Luxury Stays in Florence
Recent Florence Hotel Reviews By Fellow Wanderers
Quality Inn & Suites Florence Civic Center
5 out of 5
Posted 5 days ago
Travelocity Verified Review
"I have to say it was all especially the staff very welcoming to us when we came when I came in room is very well clean. I will definitely stay again."
A verified traveler stayed at Quality Inn & Suites Florence Civic Center
Days Inn by Wyndham Florence/I-95 North
5 out of 5
Posted 9 days ago
Travelocity Verified Review
"Good room, great price"
A verified traveler stayed at Days Inn by Wyndham Florence/I-95 North
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