Explore 12 Luxury Hotels in Florence

Best Luxury Hotels in Florence

The Mantissa Hotel

130 East Carolina Ave, Hartsville, SC

Fully refundableReserve now, pay when you stay

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9.2/10 Wonderful! (238 reviews)

"Our Stay was excellent. Staff was friendly and very professional. Will be back"

Reviewed on Jun 1, 2025

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Hotel Florence, Tapestry Collection by Hilton

126 W Evans St, Florence, SC

Fully refundableReserve now, pay when you stay

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (571 reviews)

"Victor's was excellent"

Reviewed on May 14, 2025

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Days Inn by Wyndham Florence/I-95 North

2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC

Fully refundableReserve now, pay when you stay

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...

6.8/10 (1,005 reviews)

"The room was comfortable, clean, and I intend to stay here on my way back to Florida in September."

Reviewed on Jun 7, 2025

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Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard, Florence, SC

Fully refundableReserve now, pay when you stay

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

6.6/10 (1,001 reviews)

"The property manager on duty when I arrived was very kind and made the check in process easy. The property was clean and convenient to shopping and dining. The only observation I can make is that the exhaust fan in the bathroom was disconnected, dirty and the cover was only partially attached."

Reviewed on Jun 4, 2025

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Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr, Florence, SC

Fully refundableReserve now, pay when you stay

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...

6.6/10 (1,003 reviews)

"The stay was nice"

Reviewed on May 31, 2025

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Days Inn by Wyndham Dillon

823 Radford Blvd, Dillon, SC

Fully refundableReserve now, pay when you stay

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like on-the-go breakfast and ...

5.4/10 (789 reviews)

"This place was great and the staff was very helpful. The only problem I had was when I tried to call to retrieve a forgotten item, I had to deal with an AI customer service rep who then gave me a number for the actual inn. Then nobody answered the phone. I wish it wasn't so difficult to talk to a ..."

Reviewed on Jun 4, 2025

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Clarion Inn & Suites

1819 West Lucas Street, Building A, Florence, SC

Fully refundableReserve now, pay when you stay

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like buffet breakfast and free self parking. A business ...

4.4/10 (267 reviews)

"They took a $100 deposit and haven't returned it"

Reviewed on Jun 7, 2025

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Baymont Inn & Suites Florence by Wyndham

1826 W Lucas Street, Florence, SC

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

"Still in Renovation mode"

Reviewed on Sep 3, 2024

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Florence Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florence luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Florence to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Florence will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florence, and plan your next opulent escape.

Florence hotels essential information

Accommodation	335 hotels
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Popular hotels	The Mantissa Hotel, Days Inn by Wyndham Dillon, Hotel Florence, Tapestry Collection by Hilton, Days Inn by Wyndham Florence/I-95 North, Baymont Inn & Suites Florence by Wyndham, Clarion Inn & Suites, Red Roof Inn Florence - Civic Center, Days Inn by Wyndham Florence Near Civic Center