Explore 12 Luxury Hotels in Florence

Name: The Mantissa Hotel
Price range: $181 total

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Best Luxury Hotels in Florence

Hotel Florence, Tapestry Collection by Hilton

126 W Evans St Florence SC

Fully refundableReserve now, pay when you stay

$130 nightly

$146 total

Apr 5 - Apr 6

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (620 reviews)

Nice room. Good breakfast. Interesting town

Reviewed on Feb 23, 2026

Quality Inn Dillon

817 Radford Blvd Dillon SC

Fully refundableReserve now, pay when you stay

$80 nightly

$90 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the express ...

7.2/10 Good! (783 reviews)

Seemed safer then other hotels in area. Not great but ok for a one night stay. Breakfast not great and most of the things were broken or out of service.

Reviewed on Mar 7, 2026

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence SC

Fully refundableReserve now, pay when you stay

$60 nightly

$68 total

Apr 7 - Apr 8

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

7/10 Good! (1,002 reviews)

Everything was great. I slept very well. Bed and linen were clean. Staff was friendly

Reviewed on Mar 10, 2026

Days Inn by Wyndham Florence/I-95 North

2111 West Lucas St/I-95 Florence SC

Fully refundableReserve now, pay when you stay

$62 nightly

$70 total

Mar 15 - Mar 16

Total with taxes and fees

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...

6.8/10 (1,001 reviews)

It was ok

Reviewed on Mar 12, 2026

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard Florence SC

Fully refundableReserve now, pay when you stay

$56 nightly

$63 total

Mar 16 - Mar 17

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

6.8/10 (1,003 reviews)

As always, kind staff. I stay here for work several times a year and I keep coming back

Reviewed on Mar 11, 2026

Days Inn by Wyndham Dillon

823 Radford Blvd Dillon SC

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like on-the-go breakfast and ...

5.4/10 (875 reviews)

They canceled our reservation 30 minutes before we got there. Supposedly because of an incident there.

Reviewed on Jan 9, 2026

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Clarion Inn & Suites Florence - Darlington

1819 West Lucas Street Florence SC

Fully refundableReserve now, pay when you stay

$54 nightly

$60 total

Apr 10 - Apr 11

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like on-the-go breakfast and free self parking. A business ...

4.6/10 (311 reviews)

Terrible,not a 4.6 property.do not stay here .Dirty Rooms

Reviewed on Mar 7, 2026

The Mantissa Hotel

130 East Carolina Ave Hartsville SC

Fully refundableReserve now, pay when you stay

$162 nightly

$181 total

Mar 24 - Mar 25

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Florence Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florence luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Florence to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Florence will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florence, and plan your next opulent escape.

Florence hotels essential information

Accommodation	394 hotels
Lowest Price	$60
Highest Price	$181
Popular hotels	The Mantissa Hotel, Days Inn by Wyndham Dillon, Hotel Florence, Tapestry Collection by Hilton, Days Inn by Wyndham Florence/I-95 North, Clarion Inn & Suites Florence - Darlington, Red Roof Inn Florence - Civic Center, Days Inn by Wyndham Florence Near Civic Center, Quality Inn Dillon