Explore 12 Luxury Hotels in Florence

Name: Clarion Inn & Suites Florence - Darlington
Price range: $59 total
Rating: 4.4

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Best Luxury Hotels in Florence

The Mantissa Hotel

130 East Carolina Ave Hartsville SC

Fully refundableReserve now, pay when you stay

$171 nightly

$192 total

Dec 14 - Dec 15

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9/10 Wonderful! (270 reviews)

Excellent staff and in the heart of a beautiful downtown.

Reviewed on Dec 5, 2025

Hotel Florence, Tapestry Collection by Hilton

126 W Evans St Florence SC

Fully refundableReserve now, pay when you stay

$130 nightly

$146 total

Dec 21 - Dec 22

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (601 reviews)

The room was spotless and quaint. The staff was courteous

Reviewed on Dec 1, 2025

Quality Inn & Suites

817 Radford Blvd Dillon SC

Fully refundableReserve now, pay when you stay

$77 nightly

$87 total

Jan 11 - Jan 12, 2026

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the express ...

7.2/10 Good! (758 reviews)

Staff was courteous and the room was clean.

Reviewed on Nov 11, 2025

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence SC

Fully refundableReserve now, pay when you stay

$62 nightly

$69 total

Dec 15 - Dec 16

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

6.8/10 (1,000 reviews)

Everything was great except my unwanted visitor. I had a palmetto bug in the bathroom. Having lived in the south I know they are part of life. I also wish there were softer pilllows.

Reviewed on Nov 19, 2025

Days Inn by Wyndham Florence/I-95 North

2111 West Lucas St/I-95 Florence SC

Fully refundableReserve now, pay when you stay

$59 nightly

$66 total

Dec 15 - Dec 16

Total with taxes and fees

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...

6.6/10 (1,000 reviews)

Clean room , quite area , walking distance

Reviewed on Dec 9, 2025

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard Florence SC

Fully refundableReserve now, pay when you stay

$56 nightly

$63 total

Dec 14 - Dec 15

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

6.6/10 (1,000 reviews)

room was decent

Reviewed on Nov 23, 2025

Days Inn by Wyndham Dillon

823 Radford Blvd Dillon SC

Fully refundableReserve now, pay when you stay

$60 nightly

$67 total

Dec 14 - Dec 15

Total with taxes and fees

A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like on-the-go breakfast and ...

5.4/10 (868 reviews)

Really enjoyed my stay

Reviewed on Dec 6, 2025

Clarion Inn & Suites Florence - Darlington

1819 West Lucas Street Florence SC

Fully refundableReserve now, pay when you stay

$53 nightly

$59 total

Dec 15 - Dec 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like on-the-go breakfast and free self parking. A business ...

4.4/10 (290 reviews)

The property is in flux as the rooms are modified into spacious suites. Should be great when complete, but the pool, the breakfast and even the bulbs in some room lamps were missing, as was the battery to one of the TV's. VERY nice desk personnel, however, and a great rate for our clean, large room ...

Reviewed on Sep 4, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Florence Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florence luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Florence to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Florence will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florence, and plan your next opulent escape.

Florence hotels essential information

Accommodation	368 hotels
Lowest Price	$59
Highest Price	$192
Popular hotels	The Mantissa Hotel, Days Inn by Wyndham Dillon, Hotel Florence, Tapestry Collection by Hilton, Days Inn by Wyndham Florence/I-95 North, Clarion Inn & Suites Florence - Darlington, Red Roof Inn Florence - Civic Center, Days Inn by Wyndham Florence Near Civic Center, Quality Inn & Suites