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Top Cairo hotels deals

Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 out of 5
13201 Kessler Road, Cairo, IL
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $76 total per night
$76 total
Jul 2 - Jul 3
Total includes taxes and fees
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free full breakfast each morning. A picnic area is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $70 total per night
$70 total
Jun 8 - Jun 9
Total includes taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.
Breakfast included
Pet friendly
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
$66 nightly
The price is $73 total per night
$73 total
Jun 15 - Jun 16
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business center and free internet in public areas. A safe deposit box is provided and the front desk is staffed around-the-clock.
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

$124 nightly
The price is $124 total per night
$124 total
Jun 4 - Jun 5
Total includes taxes and fees
Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Air conditioning
Lake view
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

$199 nightly
The price is $199 total per night
$199 total
Jun 4 - Jun 5
Total includes taxes and fees
This cabin features barbecue grills.
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Get rates
This vacation home features a garden, laundry facilities, and barbecue grills.
Breakfast included
Kitchen
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Fort Defiance State Park

4/5(14 reviews)

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.

Fort Defiance State Park

Frequently asked questions

How much are vacation packages to Cairo?
You’ll be pleasantly surprised — you can find yourself in Cairo for just . Allow Travelocity to save you time and money with our awesome vacation package deals. With hotels, flights and tours all in one place, what are you waiting for?
Where can I get the best vacation package deals for Cairo?
With around 400 partner airlines and 1,000,000 hotels across the world, you can’t beat Travelocity. Scroll through our impressive range and create the perfect package deal to Cairo. Doesn’t it feel amazing when organizing a trip is that easy?
Why should I book my Cairo vacation package via Travelocity?
Nothing tops the satisfaction of knowing you’ve bagged the best price around — that’s our Price Match Guarantee. Add to that our fantastic range of destinations and 24/7 team of customer service professionals and you’ve got the formula for a stress-free vacation.
Can I save on my Cairo car rental if I book it with hotels and flights?
With a Cairo vacation package, you can bundle your car, flight and hotel bookings and save some serious money. When you’re ready to explore the best of this awesome city, why not make a beeline for Anheuser-Busch Brewery? This popular attraction is 120 mi from Cairo. With your own rental car, you’ll be there in the blink of an eye.
Which airport is best for Cairo?
Williamson County Regional Airport (MWA) is 50 mi from downtown and is the beginning point for many memorable experiences. Alternatively, Cape Girardeau Municipal Airport (CGI) is 25 mi away from central Cairo and Barkley Regional Airport (PAH) is 25 mi away from central Cairo.
What is there to do in Cairo?
Click away at the excellent photo opportunities at Fort Defiance State Park, one of the most popular attractions in Cairo. There’s a lot more to discover around this exciting city, so make sure you have enough time to visit some of its off-the-beaten-path gems.
Where should I stay when visiting Cairo?
The Quality Inn Cairo I-57 is popular with many visitors. Book soon to avoid missing out.

Photos of local treasures

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