Explore top 2025 5 Star Hotels in Samos Prefecture

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Samos Prefecture 5 Star hotels

Doryssa Seaside Resort

Pythagoreiou-Choras, Samos, Samos Island

$194 nightly

$231 total

Sep 30 - Oct 1

Total with taxes and fees

A full-service spa, 2 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Enjoy beachfront dining and relax with sun loungers and beach ...

Casa Cook Samos

Potokaki, Pythagorion, Samos

Fully refundableReserve now, pay when you stay

$218 nightly

$257 total

Oct 4 - Oct 5

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Enjoy beachfront dining and relax with free beach cabanas and sun loungers. ...

Proteas Blu Resort - Adults Only

Pythagorion, Samos, Samos Island

This luxury hotel features a private beach, a full-service spa, and 3 restaurants. Relax with sun loungers and beach umbrellas, and cool off with a drink at ...

Get rates

Don't see what you're looking for?

See all available properties in Samos Prefecture

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Samos Prefecture Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Samos Prefecture to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Samos Prefecture 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Samos Prefecture before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.