Explore top 2026 4 Star Hotels in Opelousas

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Top Opelousas 4 Star hotels

DoubleTree by Hilton Hotel Lafayette

1521 W Pinhook Rd Lafayette LA

Fully refundableReserve now, pay when you stay

$93 nightly

$107 total

Oct 25 - Oct 26

Total with taxes and fees

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, free ...

8.6/10 Excellent! (1,002 reviews)

"We stayed for an event at cajundome & although getting an uber back from there was a nightmare our stay here was fantastic!! From all the friendly employees,clean room,easy parking,comfy beds,pillows,towels- it was all great!!!!!"

Reviewed on Oct 10, 2026

Enclave 3 Bedroom Luxury Homes

509 Highland Park Ln Lafayette LA

$239 nightly

$261 total

Oct 13 - Oct 14

Total with taxes and fees

This vacation home featured laundry facilities and a virtual front desk. Take advantage of the free self parking.

10/10 Exceptional! (3 reviews)

"Great Value! I highly recommend this property over hotels in the area."

Reviewed on Sep 17, 2026

Maison D'Memoire Bed & Breakfast Cottages

8450 Roberts Cove Road Rayne LA

$183 nightly

$207 total

Nov 4 - Nov 5

Total with taxes and fees

This cottage features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free full breakfast each morning. A garden and wedding services ...

9.6/10 Exceptional! (97 reviews)

"Delightful bed and breakfast venue. Real Southern charm and Lynn (the owner) was a fantastic host. Far exceeded our expectations and genuinely wished we could have stayed longer."

Reviewed on Apr 29, 2026

The Royal Inn

223 E Spring St Lafayette LA

$243 nightly

$265 total

Oct 12 - Oct 13

Total with taxes and fees

This vacation home features laundry facilities. Take advantage of the free self parking.

10/10 Exceptional! (1 review)

"Una estancia maravillosa de principio a fin. La casa es preciosa, elegantemente decorada y extremadamente limpia. Desde que entras se siente un olor delicioso y una sensación de limpieza, tranquilidad y cuidado en cada detalle. La decoración en blanco con los detalles dorados es hermosa, especialmente ..."

Reviewed on Sep 7, 2026

Decatur Inn

218 Rose St Lafayette LA

$253 nightly

$276 total

Oct 12 - Oct 13

Total with taxes and fees

This vacation home features a virtual front desk. Take advantage of the free self parking.

Esplanade Inn

217 E Spring St Lafayette LA

$230 nightly

$251 total

Oct 12 - Oct 13

Total with taxes and fees

This vacation home features laundry facilities. Take advantage of the free self parking.

Canal Inn

221 East Spring St Lafayette LA

This vacation home features laundry facilities. Take advantage of the free self parking.

Get rates

Canal Inn

221 E Spring St Lafayette LA

$223 nightly

$243 total

Oct 21 - Oct 22

Total with taxes and fees

This vacation home features laundry facilities. Take advantage of the free self parking.

Poydras Inn

215 E Spring St Lafayette LA

$233 nightly

$254 total

Oct 12 - Oct 13

Total with taxes and fees

This vacation home features laundry facilities. Take advantage of the free self parking.

Rampart Inn

216 Rose Street Lafayette LA

Stay at this vacation home in Lafayette. Enjoy free WiFi, free parking, and in-room washers/dryers. Popular attractions Ostrich Park and Lil Woods Park are located ...

Get rates

Don't see what you're looking for?

See all available properties in Opelousas

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Opelousas

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Opelousas 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Opelousas will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Opelousas, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Opelousas hotel reviews by fellow wanderers

Drury Inn & Suites Lafayette, LA

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"We love staying here. The staff is always friendly and helpful. As soon as you walk in you feel welcomed. Theresa was wonderful she helped me get my raincoat back. The nice lady that served the food and drinks was very friendly. Let’s not for the popcorn for a snack"

A verified traveler stayed at Drury Inn & Suites Lafayette, LA